Spectrophotometric Methods for the Determination of Fluoroquinolones: A Review

Kaur, Kuldeep; Kumar, Ashwini; Malik, Ashok Kumar; Singh, Baldev; Rao, A. L. J.

doi:10.1080/10408340701804400

Cited by 41 publications

(21 citation statements)

References 64 publications

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“…UV-absorbing matrices. For example, UV spectrophotometric and derivative spectrophotometric methods have been widely used for fluoroquinolones and are covered under a recent review published by Kaur et al [70].…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Rojas

Ojeda

2009

Analytica Chimica Acta

153

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Section: Pharmaceutical Analysismentioning

confidence: 99%

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Rojas

Ojeda

2009

Analytica Chimica Acta

153

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“…Also UV detection is usually used for the determination of quinolones when using more complex methods of analysis like high performance liquid chromatography (HPLC) or capillary electrophoresis (CE), in the studies of metal complexes of quinolone derivatives etc. [4,5,6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Quinolone Antibacterials: Commentary and Considerations Regarding UV Spectra and Chemical Structure

Rusu

Imre

Mircia

et al. 2015

Acta Medica Marisiensis

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Objective: Antibacterial quinolones represent an important class of pharmaceutical compounds that are widely used in therapy. Analytical methods that rely on their property to absorb light in the UV range are commonly used for their analysis. In the current study we present an interpretation of the relationship between chemical structure -UV spectra based on the comparative examination of UV spectral behavior of the eighteen quinolone derivatives and four model compounds. Methods: Eighteen quinolone derivatives and four model compounds were selected and their UV spectra were recorded in different solvents (methanol, 0.1M HCl, 0.1M NaOH).Results: The studied compounds show three absorption maximum values located around 210-230 nm, 270-300 nm and 315-330 nm values. A general characteristic was observed as the absorption bands exhibited both hypsochrome and bathochrome shifts, by comparison in different solvents. Most commonly we observed a slight hypsochrome shift at acidic pH (protonated form prevails) and basic pH (anionic form prevails). The structural differences are reflected in changes of UV spectra only when there are auxochrom substituents or different basic substituents are present in the quinolones structure. Conclusions: The correlations between the chemical structure of quinolone derivatives and their UV spectra using model compounds were established. This study provides useful information that can be used successfully in various UV spectrophotometric analysis methods or in more complex analytical methods using UV detection, and also in pharmacodynamic and kinetic studies.

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“…Fluoroquinolones are widely used to treat human and veterinary diseases [5][6][7]. Fluoroquinolones can enter cells easily and therefore are often used to treat intracellular infections.…”

Section: Introductionmentioning

confidence: 99%

“…The charge-transfer methods for fluoroquinolones reported are based on the use of 2,3,5,6-tetrachloro-p-benzoquinone with enrofloxacin, levofloxacin and ofloxacin [8], 7,7,8,8-tetracyanoquinodimethane with ciprofloxacin, norfloxacin, pefloxacin and fleroxacin [16] as well as with ofloxacin, levofloxacin and lemofloxacin [17]. Chloranilic acid is used with lemofloxacin, fleroxacin, ciprofloxacin and norfloxacin as electron donor [18].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Spectrofluorimetric Method for Determination of Fluoroquinolones through Charge-Transfer Complex Formation

Shah¹,

Jan²,

Ullah³

et al. 2013

AJAC

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A sensitive spectrofluorimetric method was developed for determination of ciprofloxacin (CPFX), levofloxacin (LEV), gatifloxacin (GAT) and moxifloxacin (MOX) in pure, commercial formulations, human urine and plasma. The method is based on charge-transfer (CT) complex with chloranilic acid. Fluorescence intensity of the complexes was measured at emission wavelength ranging from 445 -492 nm with excitation wavelengths from 285 -330 nm. At optimum experimental conditions, a linear calibration plot was obtained in the concentration range of 20 -1000 ng·mL , 20 -800 ng·mL −1 and 20 -100 ng·mL −1 for CPFX, LEV, MOX and GAT, respectively with good correlation coefficient in the range of 0.9929 -1.0 in methanolic medium. The limit of detection and limit of quantification were found to be 5 ng·mL −1 and 18 ng·mL −1 for CPFX, 12 ng·mL −1 and 40 ng·mL −1 for LEV, 8 ng·mL −1 and 19 ng·mL −1 for MOX, 6 ng·mL −1 and 19 ng·mL −1 for GAT, respectively. The method was found free of interferences from excipients used as additive in pharmaceutical preparations, some common cations and compounds present in urine and plasma as well as co-administered analgesic, vitamins and other drugs. The method was successfully applied for quantification of selected fluoroquinolones in commercial formulations and also in spiked human urine and plasma samples with percent recoveries of 100.0 ± 1.56 and 100.2 ± 1.29 respectively.

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Spectrophotometric Methods for the Determination of Fluoroquinolones: A Review

Cited by 41 publications

References 64 publications

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008

Quinolone Antibacterials: Commentary and Considerations Regarding UV Spectra and Chemical Structure

Sensitive Spectrofluorimetric Method for Determination of Fluoroquinolones through Charge-Transfer Complex Formation

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