Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations

Revanasiddappa, H. D.; Manju, B.

doi:10.1016/s0014-827x(01)01069-2

Cited by 16 publications

(7 citation statements)

References 3 publications

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“…This study is established on the reaction of diazocoupling between diazionium salt and another compound containing electronically donating groups. The pharmaceutical compounds analyzed in this reaction are those containing primary groups such as p-amino benzoic acid [13], hydroxy groups or ritodrine HCl [14]. The reactions of diazotization-coupling are those widely used in the production of dyes and in the field of analytical chemistry to estimate some of the varieties [15,16].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Taha

Al-Rufaie

Motaweq

2016

Ovidius University Annals of Chemistry

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A modern, accurate, simple and sensitive spectrophotometric procedure is tested for the appreciation of metoclopramide medicine as perspicuous form, as well as in various kinds of pharmaceutical dosages. The procedure depends on the interaction of metoclopramide (MCP) medicine and orcinol reagent by utilizing azo coupling reaction. The orcinol in NaOH solution middle to give a latterly ligand which reacts with copper (II) to output the complex with strong yellow color at 50°C. The resulting complex is water soluble, stable and can be determined spectrophotometrically at wavelength 459 nm. The calibration curve absorbance vs. concentration was established in the concentration range 0.6-12 ppm, and the curve followed the Beer’s law in this range. The procedure precision is given by the average recovery of 99.91% sequentially, as well as by the average relative standard deviation 0.70%, related to the amount of drug. The sensitivity is established at molar absorptivity 1.9044×104 l‧cm-1‧mol-1. The Sandell sensitivity is tested as 0.002 μg/cm2. The analytical results for the tested procedure agree with the official procedure. The interferences from medicine additives were tested. The established procedure is successfully examined on the appreciation of MCP in diverse kinds of pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Taha

Al-Rufaie

Motaweq

2016

Ovidius University Annals of Chemistry

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“…It decreases uterine contractility and is used to arrest premature labour and as an emergency means of alleviating foetal asphyxia during labour 1,2 . A review of literature revealed that several methods have been reported for the determination of ritodrine [3][4][5][6][7][8][9][10][11][12][13] . The chemical structure of ritodrine hydrochloride was depicted in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

A New Ritodrine Selective Electrode and its Pharmaceutical Application

Ammar

2010

Journal of Chemistry

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A novel ritodrine hydrochloride ion-selective PVC membrane electrode based on ion-pair complex of ritodrine-tetra phenyl borate was prepared withdi-n-butyl phosphate as a plasticizer. The influences of membrane composition, temperature, pH of the test solution and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a wide ritodrine concentration range (1×10−5- 1×10−2M) with a slope of 59.33 mV decade−1and was found to be very selective, precise and usable within the pH range 3-7.5. The standard electrode potentials, E°, were determined at different temperatures and used to calculate the isothermal temperature coefficient (dE°/dT) of the electrode, which was 0.00075. The electrode was successfully used for potentiometric determination of ritodrine hydrochloride both in pure solutions and in pharmaceutical preparations.

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“…Among the various methods available for the estimation of these drugs such as HPLC, Electrophoresis, Gas chromatography, Spectrophotometry method is still a preferred technique due to its simplicity and economy. Several colorimetric methods are available for the estimation of salbutamol [1][2][3][4][5][6] , ritodrine [6][7][8][9][10][11][12] , amoxicillin [13][14][15][16] and isoxsuprine 6,[17][18] .…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for the Determination of Drugs Containing Phenol Group by Using 2, 4‐ Dinitrophenylhydrazine

Nagaraja

Shrestha

2009

Journal of Chemistry

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A spectrophotometric method has been proposed for the determination of four phenolic drugs; salbutamol, ritodrine, amoxicillin and isoxsuprine. The method is based on the oxidation of 2, 4-dinitrophenylhydrazine and coupling of the oxidized product with drugs to give intensely colored chromogen. Under the proposed optimum condition, beer's law was obeyed in the concentration range of 2.5-17, 2-29, 4-33 and 5-30 µg/mL for salbutamol, ritodrine, amoxicillin and isoxsuprine respectively. The limit of detection (LOD) and limit of quantification (LOQ) were 0.2, 0.83, 0.09, 0.84 µg/mL and 0.66, 2.79, 0.3 and 2.81 µg/mL in the same order. No interference was observed from common pharmaceutical adjuvants. The ringbom plots and low relative standard deviation assert the applicability of this method. The suggested method was further applied for the determinations of drugs in commercial pharmaceutical dosage forms, which was compared statistically with reference methods by means of t-test and F-test and were found not to differ significantly at 95% confidence level. The procedure is characterized by its simplicity with accuracy and precision.

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Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations

Cited by 16 publications

References 3 publications

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

A New Ritodrine Selective Electrode and its Pharmaceutical Application

Spectrophotometric Method for the Determination of Drugs Containing Phenol Group by Using 2, 4‐ Dinitrophenylhydrazine

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