Spectrophotometric Studies on Complex Formation with Sulfosalicylic Acid. III. With Copper(II)

Turner, S.E.; Anderson, Robbin C.

doi:10.1021/ja01171a041

Cited by 61 publications

(14 citation statements)

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“…Results were plotted in the form of a graph which indicate ligand metal ratio as 2:1(L 2 M). This ratio was also confirmed by Job's method 14 of continuous variation as modified by Turner and Anderson 15 The graphs were plotted which indicates 2:1 ligand metal ratio, Fig.2(a, b); from these curves the stability constant (Log k) and free energy (-ΔF) of the complex was also calculated [16][17] and reported in table 1…”

Section: Ligand-metal Ratiomentioning

confidence: 57%

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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Glipizide is one of the most commonly prescribed drugs for the treatment of type 2 Diabetes mellitus 1 . It is about 100 times more potent than tolbutamide in evoking pancreatic secretion of insulin 2 . It is absorbed rapidly, uniformly with good mean oral bioavailability. It offers several advantages such as swift and short action with a very high selectivity 3-4 . It is a white or almost white crystalline, odourless powder, practically tasteless, insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. ABSTRACTGlipizide is a second generation sulphonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. The present paper describes the synthesis and characterization of cerium complex with Glipizide. The conductometric titration using monovariation method reveal that complex is non-ionic and ML 2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. The analytical data agree with the molecular formula (C 21 H 26 N 5 O 4 S) 2 Ce(OH 2 ) 2 , that the structure of complex was assigned as octahedral in which ligand molecules lies horizontally joining the central cerium atom. IR, NMR confirms the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure of complex was proposed on the basis of analytical data, elemental analysis, IR, 1 H NMR and X-ray Diffraction studies.

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Section: Ligand-metal Ratiomentioning

confidence: 57%

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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show abstract

“…From the equivalence point in the graph it has been concluded that the complex formation has taken place in the ratio of 2:1 (L:M). Stability constant and free energy changes were also calculated using Job's method 8 of continuous variation modified by Turner and Anderson 13 (Fig 3).…”

Section: Ligand-metal Ratiomentioning

confidence: 99%

Synthesis, Physico-Chemical and Antidiabetic Studies of Zinc Complex of Glimepiride, an Oral Hypoglycemic Agent

Jacob¹

2013

Orient. J. Chem

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“…Conductance was recorded after each addition. From the equivalence point in the graph , it has been concluded that the complex formation has taken place in the ratio of 2:1 (L:M) .Stability constants and free energy changes were also calculated by using Job's method [16]of continuous variation modified by Turner and Anderson [17]. …”

Section: Ligand -Metal Ratiomentioning

confidence: 99%

Transition Metal Complexes of Omeprazole An Anti-Ulcerative Drug

Malik¹,

Das²,

Jain³

2017

Eclet. Quim. J.

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Omeprazole (OME) is a proton pump inhibitor (PPI). PPI’s have enabled to improve the treatment of various acidpeptic disorders. OME is a weak base and it can form several complexes with transition and non-transitions metal ions. In the present paper, we are describing series of trantion metal complexes of omeprazole i.e.,5-methoxy-2[(4methoxy-3,5dimethyl-2-pyridinyl)methylsulfinyl]–1H–benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductance, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups .The complexes were found to non-electrolytic in nature on the basis of low values of molar conductance . Analytical data and stochiometry suggest ligand metal ratio of 2:1 for all the complexes. Electronic Spectra and Magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus Aureus and fungi Aspergillus niger and A. flavous.

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Spectrophotometric Studies on Complex Formation with Sulfosalicylic Acid. III. With Copper(II)

Cited by 61 publications

References 0 publications

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Synthesis, Physico-Chemical and Antidiabetic Studies of Zinc Complex of Glimepiride, an Oral Hypoglycemic Agent

Transition Metal Complexes of Omeprazole An Anti-Ulcerative Drug

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