2016
DOI: 10.1007/s00775-016-1347-x
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Spectroscopic and biological activity studies of the chromium-binding peptide EEEEGDD

Abstract: While trivalent chromium has been shown at high doses to have pharmacological effects improving insulin resistance in rodent models of insulin resistance, the mechanism of action of chromium at a molecular level is not known. The chromium-binding and transport agent low-molecular-weight chromium-binding substance (LMWCr) has been proposed to be the biologically active form of chromium. LMWCr has recently been shown to be comprised of a heptapeptide of the sequence EEEEDGG. The binding of Cr(3+) to this heptape… Show more

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Cited by 13 publications
(1 citation statement)
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“…Chromium, as a trivalent ion, is an essential trace element, although no symptoms of chromium deficiency have been reported [ 19 , 20 ]. The low-molecular-weight of chromium-binding substance (LMWCr) has been proposed to be the biologically active form of chromium, being able to activate the kinase activity of insulin receptors in a dose dependent manner and increase insulin sensitivity [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…Chromium, as a trivalent ion, is an essential trace element, although no symptoms of chromium deficiency have been reported [ 19 , 20 ]. The low-molecular-weight of chromium-binding substance (LMWCr) has been proposed to be the biologically active form of chromium, being able to activate the kinase activity of insulin receptors in a dose dependent manner and increase insulin sensitivity [ 21 ].…”
Section: Introductionmentioning
confidence: 99%