Spectroscopic and Spectrometric Methods Used for the Screening of Certain Herbal Food Supplements Suspected of Adulteration

Cristina, Maria Luisa; Popescu, Anca Mihaela; Radu, Gabriel Lucian; Onisei, Tatiana; Raducanu, Adina Elena

doi:10.15171/apb.2017.030

Cited by 15 publications

(5 citation statements)

References 25 publications

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“…The specific TDL absorption bands of the FTIR spectrum were recorded at 1675 cm −1 (properties of amides C=O 1646 cm −1 (C=C aromatic). The band of 1435 cm −1 relates to the stretching vibration C-N, and the band 746 cm −1 is representative of benzene [55]. In addition, it can be recognized from Figure 2b, which shows the characteristic DPX peaks of 4000, 3053, 2400, 1500 and 1100.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 91%

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

et al. 2020

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The study aimed at developing a liquisolid tablet (LST) containing tadalafil (TDL) and dapoxetine (DPX) with improved bioavailability as a potential therapy for male sexual dysfunction. A mixture of nonvolatile solvents, namely PEG 200 and Labrasol®, was utilized to prepare LSTs that were assessed for their quality characteristics. The Box–Behnken design (BBD) was employed to statistically explore the effect of the formulation factors on the quality attributes of LSTs. Furthermore, an in vivo pharmacokinetic study was carried out for the optimized LST in comparison with the marketed tablets on healthy human volunteers. The optimized LST revealed acceptable quality limits with enhanced dissolution for both APIs. The pharmacokinetic parameters after oral administration of the optimized LST indicated that the Cmax of TDL in LSTs was 122.61 ng/mL within 2h compared to the marketed tablets, which reached 91.72 ng/mL after 3 h, indicating the faster onset of action. The AUC was improved for TDL in LST (4484.953 vs. 2994.611 ng/mL∙h in the marketed tablet) and DPX in LST (919.633 vs. 794.699 ng/mL∙h in the marketed tablet). This enhancement in bioavailability potentially minimizes the associated side effects and improves the treatment of male sexual dysfunction, particularly for diabetic patients.

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Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 91%

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

et al. 2020

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“…Observing and comparing characteristic peaks in MIRS and Raman spectroscopy is also effective means of identification due to the significant differences between PHPs and adulterated products ( Mateescu et al., 2017 ). Slimming herbal products, adulterated with illegal additives, were discriminated against by constructing synchronous and asynchronous maps ( Miao et al., 2017 ).…”

Section: Quality and Safety Inspection Of Patent Herbal Productsmentioning

confidence: 99%

Trends in digital detection for the quality and safety of herbs using infrared and Raman spectroscopy

et al. 2023

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Herbs have been used as natural remedies for disease treatment, prevention, and health care. Some herbs with functional properties are also used as food or food additives for culinary purposes. The quality and safety inspection of herbs are influenced by various factors, which need to be assessed in each operation across the whole process of herb production. Traditional analysis methods are time-consuming and laborious, without quick response, which limits industry development and digital detection. Considering the efficiency and accuracy, faster, cheaper, and more environment-friendly techniques are highly needed to complement or replace the conventional chemical analysis methods. Infrared (IR) and Raman spectroscopy techniques have been applied to the quality control and safety inspection of herbs during the last several decades. In this paper, we generalize the current application using IR and Raman spectroscopy techniques across the whole process, from raw materials to patent herbal products. The challenges and remarks were proposed in the end, which serve as references for improving herb detection based on IR and Raman spectroscopy techniques. Meanwhile, make a path to driving intelligence and automation of herb products factories.

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“…Other characteristic bands are considered: the stretching of the secondary amides N-H at 3300 cm −1 , the N-H bending vibration at 1650-1580 cm −1 , the asymmetrical stretch of S=O at 1359 cm −1 and the symmetrical one at 1172 cm −1 [ 35 ]. IR measurements have been widely used as a fast qualitative method for the analysis of adulteration of natural products (marketed herbal aphrodisiacs) with sildenafil [ 36 , 37 ] and also for the detection of counterfeit tablets [ 38 , 39 ].…”

Section: Physiochemical Propertiesmentioning

confidence: 99%

Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era

et al. 2021

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Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5) approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Whilst twenty years have passed since its original approval by the US Food and Drug Administration (USFDA), sildenafil enters the fourth industrial era catalyzing the treatment advances against erectile dysfunction and pulmonary hypertension. The plethora of detailed clinical data accumulated and the two sildenafil analogues marketed, namely tadalafil and vardenafil, signify the relevant therapeutic and commercial achievements. The pharmacokinetic and pharmacodynamic behavior of the drug appears complex, interdependent and of critical importance whereas the treatment of special population cohorts is considered. The diversity of the available formulation strategies and their compatible administration routes, extend from tablets to bolus suspensions and from per os to intravenous, respectively, inheriting the associated strengths and weaknesses. In this comprehensive review, we attempt to elucidate the multi-disciplinary elements spanning the knowledge fields of chemical synthesis, physicochemical properties, pharmacology, clinical applications, biopharmaceutical profile, formulation approaches for different routes of administration and analytical strategies, currently employed to guide the development of sildenafil-based compositions.

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Spectroscopic and Spectrometric Methods Used for the Screening of Certain Herbal Food Supplements Suspected of Adulteration

Cited by 15 publications

References 25 publications

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

Trends in digital detection for the quality and safety of herbs using infrared and Raman spectroscopy

Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era

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