Spectroscopic, DFT analysis, antimicrobial and cytotoxicity studies of three gold(III) complexes

[AuIII(N^N)Br2](PF6): A Class of Antibacterial and Antibiofilm Complexes (N^N = 2,2′-Bipyridine and 1,10-Phenanthroline Derivatives)

“…Antimicrobial tests against Gram-positive (Staphylococcus aureus and Streptococcus intermedius) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria were carried out on compounds 1 – 4 and 6 – 9 and the corresponding N^N free ligands (Table ), while compounds 5 and 10 were not assayed for solubility reasons. It is worth mentioning that a systematic study on the antibacterial activity of these systems has never been carried out, although some studies were conducted on the biological activity of compounds 6 – 10 , ,,,− and the antimicrobial properties of related [Au­(N^N)­Cl 2 ] + systems with different diimine ligands and counteranions were occasionally investigated. ,− …”

Synthesis, spectroscopic, DFT calculations, biological activity, SAR, and molecular docking studies of novel bioactive pyridine derivatives

“…The binding energy ( BE ) represents the smallest amount of energy that required to disassemble a molecule into its constituent atoms. The values of binding energies can be calculated from the empirical relation 43 : a , b , c , d , e and f are the numbers of carbon, hydrogen, nitrogen, oxygen, sulfur or chloride in molecules. The E C , E H , E N , E O , E S and E Cl values represent the total energies of ground state for the different atoms.…”

“…The activity of the reported compounds might be attributed to the existence of NH 2 , NH, OH, C=O and C≡N functional moieties. It was suggested that the mode of action of compounds is the formation of H-bond interaction between these groups and active places of cell constitutes along with interference with normal cell 43 – 45 . The cell membranes consist of permeable lipid layers, which allow the passage of soluble lipid materials.…”

Molecular Design, Spectroscopic, DFT, Pharmacological, and Molecular Docking Studies of Novel Ruthenium(III)–Schiff Base Complex: An Inhibitor of Progression in HepG2 Cells

“…Therefore, researchers seek out other metal-based drugs, such as gold(III), gold(I), ruthenium(II), and ruthenium(III) complexes. In particular, ruthenium complexes have received a lot of attention as an alternative to platinum-based drugs due to their good biodistribution and multimodal actions [ 4 , 5 , 6 ]. Numerous ruthenium complexes have exhibited remarkable antitumor activity, and some of them have various advantages over platinum drugs, such as potent efficacy, less drug resistance, and low toxicity [ 7 , 8 , 9 ].…”

“…Our interest in synthesizing many Ru(II)– and Ru(III)–Schiff base complexes and investigating their biological and medicinal activity as potential anticancer agents [ 6 , 11 , 21 , 22 ] has prompted us to design more novel Schiff base–ruthenium complexes. The unique characteristics of ruthenium–pyrimidine base derivatives as promising bioactive agents encouraged us to synthesize and investigate a novel Ru–pyrimidine Schiff base.…”