Spectroscopic, DFT, biological, DNA-binding, and antioxidant studies of some metal chelates with a novel thiazole-derived Schiff base

Mohamed, Rania G.; Makhlouf, Abdelmoneim A.; Mosad, Sherin A.; Aziz, Ayman A. Abdel; El‐Medani, Samir M.; Ramadan, Ramadan M.

doi:10.1080/00958972.2018.1526375

Cited by 21 publications

(20 citation statements)

References 71 publications

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“…Furthermore, coordination of Zn 2+ ion through the nitrogen of the azomethine and the hydroxyl group was supported based on the orientation of the functional groups of TYMN. Additionally, both the X-ray 39 and the theoretical analyses of the TYMN probe supported that TYMN could coordinate to metal as bidentate ligand. Finally, for TYMN-Zn complex, theoretical analysis suggested a minimum tetrahedral geometry with an energy of 265.70 kcal mol −1 , 1.92 and 1.88 Å for Zn−N and Zn−O bond distances, respectively.…”

Section: Theoretical Studiesmentioning

confidence: 83%

“…As shown in Scheme 1, the novel sensor, (E)-3-((thiazol-2-ylimino)methyl)naphthalen-2-ol (TYMN), was prepared according to the literature, 39 with some modification under the effect of microwave radiation. A homogeneous mixture of 2-aminothiazole (2.0 g, 20 mmol), 2-hydroxy-1-naphthaldehyde (3.4 g, 20 mmol), acetic acid (0.2 mL) in methanol (10 mL), was put in a microwave reaction vessel equipped with a magnetic stirrer.…”

Section: Microwave Assisted Sensor Synthesis Of Tmyn and Characterizamentioning

confidence: 99%

“…Finally, for TYMN-Zn complex, theoretical analysis suggested a minimum tetrahedral geometry with an energy of 265.70 kcal mol −1 , 1.92 and 1.88 Å for Zn−N and Zn−O bond distances, respectively. 39…”

Section: Theoretical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

A Simple Fluorescent Chemosensor for Detection of Zinc Ions in Some Real Samples and Intracellular Imaging in Living Cells

Aziz

Aboelhasan

Sayed

2020

J. Braz. Chem. Soc.

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A new designed fluorescent chemosensor TYMN ((E)-1-((thiazol-2-ylimino)methyl) naphthalen-2-ol) for highly sensitive and selective tracing of trace amount of Zn 2+ ions in some real samples was synthesized and characterized. The sensor TYMN can detect Zn 2+ ions via fluorescence enhancement with a high selectivity over a wide range of metal ions, especially Cd 2+. The sensor showed large fluorescence enhancement upon complexation with Zn 2+ and simultaneous color change from yellow to orange. The limit of detection was analyzed to be 0.0311 μM with a linear dynamic range 0.1-1.0 μM. The sensor could work in a pH span of 5.0-8.0. Based on the physicochemical and analytical methods like electrospray ionization (ESI)-mass, Job plot, 1 H nuclear magnetic resonance (NMR) and theoretical calculations, the detection mechanism for Zn 2+ was explained based on restriction of internal charge transfer (ICT) mechanism. TYMN sensor was potentially utilized for Zn 2+ ions concentration evaluation in some real samples. Fluorescence microscopy experiments revealed that probe TYMN may have application as a fluorophore to detect the Zn 2+ in living cells.

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Section: Theoretical Studiesmentioning

confidence: 83%

Section: Microwave Assisted Sensor Synthesis Of Tmyn and Characterizamentioning

confidence: 99%

See 1 more Smart Citation

A Simple Fluorescent Chemosensor for Detection of Zinc Ions in Some Real Samples and Intracellular Imaging in Living Cells

Aziz

Aboelhasan

Sayed

2020

J. Braz. Chem. Soc.

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“…Experimental details of the investigations are as described previously. [ 27 ] The antibacterial activities were scanned against two bacterial species: Staphylococcus aureus (gram positive) and Escherichia coli (gram negative). Ampicillin was used as a standard.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed procedure for the DPPH free radical scavenging activity studies is previously given. [ 27 ]…”

Section: Methodsmentioning

confidence: 99%

Spectroscopic, density functional theory, nonlinear optical properties and in vitro biological studies of Co(II), Ni(II), and Cu(II) complexes of hydrazide Schiff base derivatives

Ramadan

El‐Medani

Makhlouf

et al. 2021

Applied Organom Chemis

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Complexes of three molecularly designed phenylacetohydrazide Schiff base derivatives—N′‐(2‐hydroxybenzylidene)‐2‐phenylacetohydrazid (HL1), N‐(1‐(2‐hydroxyphenyl)ethylidene)‐2‐phenylacetohydrazide (HL2), and N′‐((1‐hydroxynaphthalen‐2‐yl)methylene)‐2‐phenylacetohydrazide (HL3)—with some bivalent metal ions were synthesized and investigated by several spectroscopic and analytical techniques. The crystal structure of HL1 ligand has been solved by conventional X‐ray diffraction technique. Molecular geometries of HL1 and the studied complexes were investigated using the DFT‐B3LYP/GENECP level of theory. Quantum and non‐quantum global reactivity descriptors as well as the nonlinear optical properties were calculated. Biological parameters such as antimicrobial and antioxidant activities, fluorescence quenching studies, and viscosity measurements of the complexes were carried out. Molecular docking studies of HL1 and complexes using Molecular Operating Environment (MOE) software are reported. The different biological studies and the molecular docking were correlated to each other. The biological studies supported that the complexes can bind to DNA via intercalative mode and showed a various DNA binding potency.

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New transition metal complexes of 1‐phenyl‐2‐((quinolin‐2‐ylmethylene)amino)ethan‐1‐ol Schiff base: Spectroscopic, X‐ray, DFT, Hirshfeld surface analysis, biological, and molecular docking studies

Elantabli

El‐Medani

Kozakiewicz‐Piekarz

et al. 2022

Applied Organom Chemis

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A novel Schiff base ligand (HL), derived from the condensation of phenylethanolamine and quinoline‐2‐carboxaldehyde, and its coordination complexes with some transition metal ions, Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Pd(II), were synthesized. The reported new compounds were characterized using different analytical and spectroscopic techniques. The structure of HL and its cobalt complex was also solved by conventional X‐ray diffraction technique. Hirshfeld surface analysis of the ligand and cobalt complexes was investigated. Interesting structural features with unique hydrogen bonding formation were observed. Molecular geometries of HL and the reported complexes were investigated using the DFT‐B3LYP level of theory. The quantum global reactivity descriptors were also calculated. Biological screening and molecular docking studies of the ligand and complexes are reported to explore their potential application as therapeutic drugs. The biological studies and molecular docking were correlated to each other and with the quantum reactivity descriptors. The studies supported that the complexes could bind to DNA via intercalative mode and showed various DNA binding potency.

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Spectroscopic, DFT, biological, DNA-binding, and antioxidant studies of some metal chelates with a novel thiazole-derived Schiff base

Cited by 21 publications

References 71 publications

A Simple Fluorescent Chemosensor for Detection of Zinc Ions in Some Real Samples and Intracellular Imaging in Living Cells

A Simple Fluorescent Chemosensor for Detection of Zinc Ions in Some Real Samples and Intracellular Imaging in Living Cells

Spectroscopic, density functional theory, nonlinear optical properties and in vitro biological studies of Co(II), Ni(II), and Cu(II) complexes of hydrazide Schiff base derivatives

New transition metal complexes of 1‐phenyl‐2‐((quinolin‐2‐ylmethylene)amino)ethan‐1‐ol Schiff base: Spectroscopic, X‐ray, DFT, Hirshfeld surface analysis, biological, and molecular docking studies

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