Spectroscopic Methods in Biology, with Application to Neurophysiology

Martin, Albert R.

doi:10.1016/b978-0-12-005214-1.50009-1

Advances in Biological and Medical Physics

1973

DOI: 10.1016/b978-0-12-005214-1.50009-1

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Spectroscopic Methods in Biology, with Application to Neurophysiology

Albert R. Martin

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1974

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The Secondary Structure of Human Hageman Factor (Factor XII) and its Alteration by Activating Agents

McMillin¹,

Saito²,

Ratnoff³

et al. 1974

J. Clin. Invest.

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A B S T R A C T Hageman factor (factor XII) is activated by exposure to surfaces such as glass or by solutions of certain compounds, notably ellagic acid. Changes in the structure of Hageman factor accompanying activation have been examined in this study by circular dichroism spectroscopy. The spectrum of unactivated Hageman factor in aqueous solutions suggests that its conformation is mainly aperiodic. Various perturbants altered the conformation of Hageman factor in differing ways, demonstrating the sensitivity of Hageman factor to its environment.After activation of Hageman factor with solutions of ellagic acid, a negative trough appeared in the region of the circular dichroism spectrum commonly assigned to tyrosine residues, along with other minor changes in the peptide spectral region. Some of these changes are similar to changes that occurred upon partial neutralization of the basic residues at alkali pH. Activation of Hageman factor by adsorption to quartz surfaces (in an aqueous environment) also produced changes similar to those in the ellagic acid-activated Hageman factor, including the negative ellipticity in the tyrosine region.These observations suggest that the activation process may be related to a change in status of some of the basic amino acid residues, coupled with a specific change in the environment of some tyrosine residues. The importance of these changes during the activation process remains to be determined. The

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The Secondary Structure of Human Hageman Factor (Factor XII) and its Alteration by Activating Agents

McMillin¹,

Saito²,

Ratnoff³

et al. 1974

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

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Spectroscopic Methods in Biology, with Application to Neurophysiology

Cited by 1 publication

References 172 publications

The Secondary Structure of Human Hageman Factor (Factor XII) and its Alteration by Activating Agents

The Secondary Structure of Human Hageman Factor (Factor XII) and its Alteration by Activating Agents

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