Spectroscopy characterization, theoretical study and antioxidant activities of the flavonoids-Pb(II) complexes

Wang, Qian; Zhao, Haoan; Zhu, Min; Gao, Liguo; Ni, Cheng; Cao, Wei

doi:10.1016/j.molstruc.2020.127919

Cited by 25 publications

(20 citation statements)

References 43 publications

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“…In recent years, studies have shown that traditional Chinese medicine (TCM) and medicinal plants can remove lead ion from blood and body organs ( Xia et al., 2010 ; Aladaileh et al., 2020 ; Wang et al., 2020 ). S. glabra as a TCM, has been used for the treatment of lead poisoning over hundreds of years ago in China.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Shi

Tian

et al. 2020

Front. Pharmacol.

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Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. Smilax glabra Roxb. has been used for treatment of heavy-metal poisoning in China for 500 years. We investigated S. glabra flavonoids extract (SGF) could attenuate lead acetate-induced nephrotoxicity in weaning rats and human embryonic kidney (HEK)-293 cells, and investigated the possible mechanisms. Compared with Pb exposed group of weaning rats, SGF could significantly promote lead excretion in the blood and kidney, and increase the content of the renal-function indicators blood urea nitrogen, serum uric acid, and serum creatinine. SGF could improve the glomerular filtration rate (GFR) and histologic changes in the kidneys of weaning rats exposed to Pb. SGF could also reduce lead-induced cytotoxicity, improve DNA damage-induced apoptosis and cleaved caspase-3-mediated apoptosis in HEK-293 cells stimulated with Pb. SGF significantly increased the activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase, and decreased excessive release of reactive oxygen species (ROS) and malondialdehyde in the kidneys of the weaning rats and in HEK-293 cells. The antioxidant mechanism of SGF related to activation of the Kelch-like ECH-associated protein 1/nuclear-factor-E2-related factor 2/hemeoxygenase-1(Keap1/Nrf2/HO-1) pathway. SGF could inhibit secretion of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α induced by Pb in vivo and in vitro . The anti-inflammatory mechanism of SGF related to inhibition of ROS and pro-inflammatory cytokines triggered the nuclear factor-kappa B (NF-κB) pathway through blockade of inhibitors of I-κB degradation, phosphorylation of NF-κB p65, and nuclear translocation of p65. Our findings indicate that SGF could be a natural antioxidant and anti-inflammatory agent for treating lead-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

“…The functional oxo groups and hydroxyl groups of flavonoids play a key part in metal-chelating capacities ( Wang Q. et al., 2019 ). Lead-kaempferol- and lead-quercetin-chelating complexes possess strong antioxidant abilities in ferric reducing power assay and ABTS radical-scavenging systems ( Wang et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Shi

Tian

et al. 2020

Front. Pharmacol.

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“…Also, bands between 1000 and 1200 cm -1 correspond to C-O stretch band. 15,16 The multivariate analysis of these data resulted in the groupings observed in Figure 2. This time the first and second principal components had a cumulative variance of 55.37 %.…”

Section: Multivariate Analysis Of Uv-vis and Ir Fingerprintsmentioning

confidence: 99%

“…For example, in flavonols Band I (absorption due to B-ring) is usually within 300 ˗ 380 nm and Band II (absorption due to A-ring) within 240˗280 nm. 1,10,15 Figure 1 shows the grouping of Bauhinia samples resulting from PCA of UV-Vis spectra. Altogether, the first and second principal components explain 96.20 % of the variability of the extracts.…”

Section: Multivariate Analysis Of Uv-vis and Ir Fingerprintsmentioning

confidence: 99%

“…Specially, kaempferol, quercetin and myricetin, both aglycones and glycosides, are potent natural antioxidants due to the presence of catechol moiety in ring B (quercetin), the presence of the 3-hydroxyl and 5-hydroxyl groups and the additional hydroxyl group in ring B (pyrogallol group) which seems to enhance further the antioxidant capacity (myricetin). 15,[20][21][22][23]…”

Section: Evaluation Of Antiradical Activitymentioning

confidence: 99%

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Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

Pianoski¹,

Turco²,

Soares³

et al. 2020

Rev. Virtual Quim.

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Resumo: Algumas espécies de plantas do gênero Bauhinia são plantas medicinais com relevantes propriedades diuréticas, digestivas, anti-inflamatórias, analgésicas, sendo popularmente usadas no tratamento da hipertensão e do diabetes. As plantas deste gênero são conhecidas como "pata-de-vaca" devido ao formato de suas folhas; essa similaridade morfológica entre espécies e/ou subespécies torna sua diferenciação taxonômica um desafio. Buscando uma ferramenta auxiliar para discriminar espécies de Bauhinia, as impressões digitais espectroscópicas e espectrométricas dos extratos das folhas foram comparadas usando a análise de componentes principais (PCA). As amostras foram diferenciadas de acordo com o tipo (comercial ou não comercial), região de origem e espécie. A análise indicou que existem diferenças de perfil químico entre as amostras comerciais e não comerciais possivelmente originadas pela mistura de diferentes espécies de Bauhinia nas amostras comerciais. Desta forma, a PCA é uma ferramenta auxiliar na autenticação de amostras comerciais e não comerciais, rastreamento de origem e classificação taxonômica. Além disso, a atividade antirradicalar foi estatisticamente superior para amostras não comerciais (p<0,05), sugerindo que essa atividade diminui durante o armazenamento na prateleira. Some species of plants of the genus Bauhinia are medicinal plants with relevant pharmaceutical properties such as diuretic, digestive, anti-inflammatory, analgesic and are popularly used to treat hypertension and diabetes. They are widely known as "cow's foot" ("pata-de-vaca") due to the shape of their leaves; this morphological similarity among species and/or subspecies makes their taxonomic differentiation a challenge. Seeking for an auxiliary tool to discriminate Bauhinia species, spectroscopic and spectrometric fingerprints of extracts of Bauhinia leaves were compared using principal component analysis (PCA). Samples were distinguished according to their type (commercial or non-commercial), geographic origin, and specie. Multivariate data analysis indicated that there are differences between the chemical profile of commercial and non-commercial samples possibly due to the mixture of different species of Bauhinia in commercial samples. Thus, PCA may help to authenticate commercial and non-commercial samples, to trace their origin and indicate taxonomic classification. Additionally, the antiradical activity was statistically higher for non-commercial samples (p<0.05), suggesting that this activity diminishes during shelf storage.

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Site‐Selective Coordination Assembly of Dynamic Metal‐Phenolic Networks

Pan

Noble

et al. 2022

Angewandte Chemie

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Coordination states of metal‐organic materials are known to dictate their physicochemical properties and applications in various fields. However, understanding and controlling coordination sites in metal‐organic systems is challenging. Herein, we report the synthesis of site‐selective coordinated metal‐phenolic networks (MPNs) using flavonoids as coordination modulators. The site‐selective coordination was systematically investigated experimentally and computationally using ligands with one, two, and multiple different coordination sites. Tuning the multimodal Fe coordination with catechol, carbonyl, and hydroxyl groups within the MPNs enabled the facile engineering of diverse physicochemical properties including size, selective permeability (20–2000 kDa), and pH‐dependent degradability. This study expands our understanding of metal‐phenolic chemistry and provides new routes for the rational design of structurally tailorable coordination‐based materials.

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Spectroscopy characterization, theoretical study and antioxidant activities of the flavonoids-Pb(II) complexes

Cited by 25 publications

References 43 publications

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

Site‐Selective Coordination Assembly of Dynamic Metal‐Phenolic Networks

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