Spectrum–effect relationship combined with bioactivity evaluation to discover the main anxiolytic active components of Baihe Dihuang decoction

Pharmacological Components and Mechanism Research on the Treatment of Myelosuppression after Chemotherapy with Danggui Jixueteng Decoction Based on Spectrum-Effect Relationships and Transcriptome Sequencing

“…The gray system theory examines the degree of correlation between the factors of the system through the quantitative analysis of the dynamic development process of the system, and its main method is to construct the degree of correlation based on the similarity of the development process or magnitude between two sequences and to construct the degree of correlation by reflecting the similarity of the development trend of two sequences. This method of detecting the degree of influence between two factors through the similarity of trends or curve shapes can inform decision-making and the judgment of the main factors …”

“…This method of detecting the degree of influence between two factors through the similarity of trends or curve shapes can inform decision-making and the judgment of the main factors. 18 …”

“…This method of detecting the degree of influence between two factors through the similarity of trends or curve shapes can inform decision-making and the judgment of the main factors. 18 As shown in Tables S2−S8, there were 20, 17, 18, 21, 8, 20, and 19 peaks with a correlation greater than 0.6 with WBC, RBC, PLT, IL-3, HGB, GM-CSF, and NCC, respectively. Considering the seven pharmacological indicators mentioned above, there were a total of eight peaks highly correlated with them: numbers 2, 7, 10, 14, 15, 16, 18, and 21.…”

Microbiome Metabolomic Analysis of the Anxiolytic Effect of Baihe Dihuang Decoction in a Rat Model of Chronic Restraint Stress

“…At present, BDD is still used in clinical practice for treating patients with anxiety disorder, and it has also been found to exert anxiolytic-like effects in animals. 5–7 …”

“…In our previous study, the main anxiolytic ingredients of BBD were detected through the use of the spectrum–effect relationship, and these included regalosides A, B, C, D, and H, acteoside, and isoacteoside. 5 The anxiolytic function of catalpol is mediated by upregulating the expression of brain-derived neurotrophic factor and repairing the hypothalamus–pituitary–adrenal (HPA) axis. 8 Acetoside (verbascoside) exhibits anxiolytic effects through its interaction with gamma-aminobutyric acid (GABA) A receptors, 9 while regaloside A plays an important neuroprotective role by modifying brain-derived neurotrophic factor and tyrosine kinase receptor B.…”