2007
DOI: 10.2215/cjn.01700407
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Spectrum of Renal Pathology in Hematopoietic Cell Transplantation

Abstract: Background and Objectives: Hematopoietic cell transplantation is a common treatment option for a variety of hematopoietic malignancies. As a result of the use of total body irradiation and/or chemotherapeutic agents, renal dysfunction often ensues. Many pharmacologic agents, such as cyclosporine and high-intensity conditioning regimens, have been linked with thrombotic microangiopathy. In addition, an association between membranous nephropathy and graft-versus-host disease has been reported in this clinical se… Show more

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Cited by 99 publications
(96 citation statements)
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“…8,11,14,16,18,39,45 We encountered focal segmental glomerulosclerosis in 3 of 14 (21%, patient nos. 6-8) patients with renal biopsy.…”
Section: Discussionmentioning
confidence: 89%
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“…8,11,14,16,18,39,45 We encountered focal segmental glomerulosclerosis in 3 of 14 (21%, patient nos. 6-8) patients with renal biopsy.…”
Section: Discussionmentioning
confidence: 89%
“…[7][8][9] Numerous descriptive studies, derived from groups of kidney core biopsy specimens from hematopoietic cell transplant recipients with renal dysfunction, have characterized the most common types of glomerulonephritis in hematopoietic cell transplant patients. 8,[10][11][12][13][14][15][16][17][18] These include membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. In addition, acute and chronic thrombotic microangiopathy, or 'transplant-associated thrombotic microangiopathy,' has been shown to occur commonly in hematopoietic cell transplant recipients, 8,14,[17][18][19][20][21][22][23][24][25] with smaller reported numbers of membranoproliferative glomerulonephritis, proliferative glomerulonephritis, ANCA-associated glomerulonephritis, and IgA nephropathy.…”
mentioning
confidence: 99%
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“…[4][5][6][14][15][16][18][19][20][21][22][23][24][25][26][27][28][29] In our series, among seven patients with membranous glomerulonephritis, all five patients with allogeneic transplants had evidence of chronic graft-versushost disease, (in the non-membranous glomerulonephritis cohort, only three out of eight patients had chronic graft-versus-host disease). Importantly, we also present two patients with biopsy proven membranous glomerulonephritis after autologous hematopoietic cell transplantation.…”
Section: Discussionmentioning
confidence: 99%