Speech characteristics in individuals with myasthenia gravis: a case control study

Ayres, A. Jean; Winckler, Pablo Brea; Jacinto-Scudeiro, Laís Alves; Rech, Rafaela Soares; Padovani, Marina; Jotz, Geraldo Pereira; Olchik, Maira Rozenfeld

doi:10.1080/14015439.2020.1834614

Cited by 7 publications

(10 citation statements)

References 26 publications

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“…These were the parameters that distinguished the myasthenic patients from the controls. This finding is similar to results that other authors have described ( 8 - 10 , 12 ) . These are characteristics of the phonatory progression in MG.…”

Section: Discussionsupporting

confidence: 93%

“…In addition, the percentage of patients diagnosed with dysarthria increased from 40% to 90%. We found a higher prevalence than the literature (50 to 60% throughout the course of the disease) ( 6 - 8 ) .…”

Section: Discussioncontrasting

confidence: 73%

“…Via telephone, MG patients who participated in a previous study ( 8 ) were invited to participate in the new investigation. These individuals were follow-up outpatients at the tertiary referral clinic for neuromuscular diseases at the Hospital de Clínicas de Porto Alegre (HCPA), in Brazil.…”

Section: Methodsmentioning

confidence: 99%

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Did the speech of patients with Myasthenia Gravis decline over 4 years?

Ayres,

Padovani,

Olchik

et al. 2024

CoDAS

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Purpose To compare the speech and voice patterns of myasthenia gravis (MG) patients over four years, and correlate the results with clinical aspects of the disease. Methods Data was collected for 4 years. The clinical assessment tools included the Quantitative Myasthenia Gravis (QMG) score, the Myasthenia Gravis Foundation of America (MGFA) clinical classification, and the Myasthenia Gravis Quality of Life 15-item Scale (MG-QoL). To assess speech, the recorded speaking tasks were analyzed acoustically and given auditory-perceptual ratings. Sex (equal distribution) and age (p=0.949) were used as matching criteria in the final sample, which consisted of 10 individuals in the MG group (MGG) and 10 individuals in the control group (CG). Results After 4 years, the MG participants presented stable health status, increased mild and moderate dysarthria (from 40% to 90% of the subjects), and a significant deterioration in the respiration, phonation, and articulation subsystems. The acoustic analysis showed a decline in articulatory patterns (speech rate p=0.047, articulation rate p=0.007, mean syllable duration p=0.007) and vocal quality (increased jitter p=0.022). In the follow-up comparison, there was a significant difference between the phonation variables (shimmer and harmonic-to-noise ratio) of the MGG and CG. Conclusion The MG patients presented a decline in speech over four years and an increase in mild and moderate dysarthria. Despite presenting stable health status, their respiratory, phonatory, and articulatory subsystems worsened. There was no correlation between speech patterns and clinical characteristics of the disease (severity and motor scale).

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 73%

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Did the speech of patients with Myasthenia Gravis decline over 4 years?

Ayres,

Padovani,

Olchik

et al. 2024

CoDAS

Self Cite

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“…The measured parameters of computerized voice analysis, which is now widely used for acoustic monitoring, can be used for the objective assessment of voice quality. Sheng et al 29 evaluated MG patients with dysarthria using this technique, highlighting the value of computerized acoustic examination for both diagnostic and therapeutic evaluation in patients with MG. Ayres et al 30 also used computerized acoustic tests for voice data collection, perceptualauditory voice analysis, and voice acoustic analysis in MG patients and healthy controls. The authors found that the MG questionnaire was not sufficiently sensitive to differentiate patients with greater and lesser speech impairment.…”

Section: Discussionmentioning

confidence: 99%

Isolated dysarthria as the sole manifestation of myasthenia gravis: a case report

Jiang

et al. 2022

J Int Med Res

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Myasthenia gravis (MG) is an acquired autoimmune disease. Its clinical manifestations comprise ptosis, diplopia, dysarthria, dysphagia, limb weakness, and in severe cases, respiratory muscle involvement. Dysarthria as an exclusive initial and primary complaint in MG is rare and seldom reported. In this paper, we report a case of type IIIb MG with isolated dysarthria as the only clinical manifestation and we review the relevant literature. The patient was a 62-year-old man who presented with episodes of slurred speech for 20 days that had worsened in the previous 9 days. His medical history comprised hypertension, diabetes mellitus, and coronary heart disease. The initial diagnosis on admission was transient ischemic attack. Careful re-examination of the patient’s history revealed that his symptoms mainly involved increasingly worse slurred speech episodes without drinking or swallowing difficulties, and no significant improvement with rest was observed. Electromyography and autoantibody profiling led to a diagnosis of type IIIb MG. His symptoms improved after the oral administration of pyridostigmine bromide 60 mg. Laryngeal MG is important to differentiate from stroke. It is necessary to perform a computerized voice analysis when encountering patients with atypical symptoms of MG.

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“…Mild dysarthria is common in MG, and speech therapy may improve function [76] . Local muscle weakness can influence oral health.…”

Section: Article In Pressmentioning

confidence: 99%