Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility

Belloc, S.; Benkhalifa, Moncef; Cohen-Bacrie, M.; Dalléac, Alain; Amar, Edouard; Zini, Armand

doi:10.1016/j.fertnstert.2014.02.006

Cited by 72 publications

(62 citation statements)

References 45 publications

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“…Belloc et al, surveyed 1974 normozoospermic semen samples and 4345 samples from infertile men, and the cutoff value of >30% SDF was significantly more prevalent in the infertile group [19]. In the normozoospermic group, the mean SDF value was 17.6%.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure

Kishi¹

2015

JCDR

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Section: Discussionmentioning

confidence: 99%

Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure

Kishi¹

2015

JCDR

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“…Several studies have shown an association between sperm motility and leukocyte Mahmoud et al [7] T/LH ↓ Young: 5.5 nmol/U Older: 2.5 nmol/U contamination in ejaculate, ROS production, lipid peroxidation, and sperm oxidative DNA damage [72,77,78]. Some studies have indicated higher levels of dsDNA breaks and higher DNA fragmentation index (DFI) in older men [79][80][81][82] (Table 4). An imbalance between antioxidant defence mechanisms and ROS production eventually results in poor quality DNA, lipids, and proteins in the course of aging [88].…”

Section: Free Radical Theory Of Aging and Apoptosismentioning

confidence: 98%

“…Sperm DFI is positively correlated with sperm paternal aging (p < 0.00001). Furthermore, high oxidative stress leads to increased apoptosis and spermatozoal DNA damage [79]. Although apoptosis is essential for spermatogenesis under normal conditions, the balance between proliferation of spermatogonia and apoptosis of different germ cell types appears to be disturbed with aging [91].…”

Section: Free Radical Theory Of Aging and Apoptosismentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

196

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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“…DNA damage in mature spermatozoa seems to be strongly linked to subfertility. Further, for those damaged spermatozoa that do successfully fertilize an oocyte, the consequent effect of suboptimal paternal DNA integrity on the developing conceptus has become a subject of intense investigation (14,15). Here, we share our perspective on the DNA status assays that are carried out on the male gamete, and the repercussions they may have for counseling and treating infertile men with this condition.…”

mentioning

confidence: 99%