Sperm Functions Influenced by Immune Reactions

Krause, Walter

doi:10.1007/978-3-642-01379-9_4

Cited by 6 publications

(9 citation statements)

References 68 publications

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“…The ASA-associated disorders, such as lower sperm motility, acrosome reaction impairment, hindered cervical mucus penetration, capacitation and oocyte fertilization failure that are described by many authors (Mazumdar & Levine, 1998;Walsh & Turek, 2009;Francavilla & Barbonetti, 2009;Check, 2010; and others), may not be important from the clinical point of view nowadays? We think that new data on the functional sperm disorders in ASA-positive patients including DNA fragmentation (Bozhedomov et al, 2014) may explain the higher rate of spontaneous abortions in such couples which was found in the beginning of IVF use (Mazumdar & Levine, 1998;Krause, 2009), and may draw the interest of clinicians to this topic.…”

Section: Discussionmentioning

confidence: 96%

“…Nowadays, the sperm functional disorders, such as inadequate or preterm acrosome reaction, increased DNA fragmentation, etc., are the leading factors of decreased fertility in autoimmune reactions against spermatozoa (Francavilla & Barbonetti, 2009;Krause, 2009;Bozhedomov et al, 2014;and others). This calls for additional research.…”

Section: Discussionmentioning

confidence: 99%

“…It must be kept in mind that ASA are frequent in varicocele patients: 25-40% of cases are detected in motile sperm count evaluation (Mazumdar & Levine, 1998;Francavilla & Barbonetti, 2009;Krause, 2009;Walsh & Turek, 2009). It is noteworthy that lack of ASA decrease after varicocelectomy supports the opinion that varicocele is not the immediate cause of the immune infertility as several authors believe (Walsh & Turek, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The ASA cause the sperm agglutination and decrease its motility as well as impair the sperm penetration into cervical mucus and hinder the fertilization of the ovum; the ASA can affect the fetal early development, implantation and gestation course (Mazumdar & Levine, 1998;Francavilla & Barbonetti, 2009;Krause, 2009;Walsh & Turek, 2009;Check, 2010). Recently we showed that immune infertility is found in 15% of varicocele patients.…”

Section: Introductionmentioning

confidence: 99%

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The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

et al. 2014

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SUMMARYAntisperm antibodies (ASA) are a cause of male infertility. ASA are often found in varicocele patients. The study objective was to assess the ASA role in fertility recovery after varicocelectomy. The longitudinal study involved 99 patients with varicocele. Patients were examined according to the WHO recommendations; ASA level was measured using the direct method of Sperm MAR test: 66 patients were ASA-negative, 33 had MAR-IgG ≥ 10%. All patients underwent microsurgical varicocelectomy. Student's t-test, Wilcoxon test, Chi-squared test and signed rank test were used for data analysis. The retrospective analysis of all operated patients data showed that the patients without spermiogram improvement after varicocelectomy had higher ASA levels. 3 months after the surgery, the initially ASA-negative varicocele patients demonstrated 2.5 times increase in number of progressive motile spermatozoa in the ejaculate (p < 0.001), accompanied by 6% decrease in abnormal sperm count (p < 0.05); the spermiogram parameters improved in 77% of cases (p < 0.01). After the surgery, ASA developed in 16% of cases (Max -MAR-IgG = 12%). The patients who were initially ASA-positive demonstrated ASA decrease only in half of the cases (16 of 33; p > 0.05). The main outcome in this group was a favourable response to the surgery (ASA level decrease) vs. no reduction in autoimmune process. The improvement in the ASA-positive group was demonstrated in the patients with higher varicocele grade (median -2 vs. 1; p < 0.05) and lower ASA level (MARIgG = 48% vs. 92%; p < 0.01). The pregnancy rate within a year after surgery was 2.8 times more frequent in couples with ASA-negative men: 39% (25 of 65) in the ASA-negative group compared to 14% (4 of 28) in the ASA-positive group (p < 0.05). Thus, antisperm immune response decreases the varicocelectomy efficacy for reproductive function recovery: the higher percentage of ASA and lower grade of varicocele are associated with an unfavourable prognosis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

et al. 2014

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“…Our findings suggest that the antisperm immune response in varicocoele patients is associated with the decrease in quantitative parameters of a standard spermogram and the deterioration of the sperm functional properties such as AR disorder (both spontaneous and induced) and DNA fragmentation. The primary effect of autoimmune reactions on the sperm quality is a decrease in motility, agglutination and AR disorders (Bohring & Krause, ; Francavilla & Barbonetti, ; Krause, ). We found that ASA‐positive varicocoele patients demonstrated a more significant decrease in the semen quality (concentration, total number of progressively motile spermatozoa) which correlates with the grade of spermatic cord veins dilatation.…”

Section: Discussionmentioning

confidence: 99%

Male fertility and varicocoele: role of immune factors

et al. 2013

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SUMMARYThe role of antisperm antibodies (ASA) in the aetiopathogenesis of varicocoele-related male infertility remains unclear. The objective of this study was to determine whether varicocoele is associated with antisperm immune response and whether this factor provides additional affect on male fertility. We performed a multicentral, prospective study that included the clinical examination of 1639 male subjects from infertile couples and 90 fertile men, the evaluation of the absolute and relative risks of immune infertility associated with varicocoele and the impact of the autoimmune response on the semen quality. The methods used were as follows: standard examination of seminal fluid according to WHO criteria; ASA detection in seminal fluid using mixed antiglobulin reaction (MAR) and direct flow cytometry; measurement of spontaneous and ionophore-induced acrosome reactions; oxidative stress evaluation with luminal-dependent chemiluminescence method and evaluation of DNA fragmentation by sperm chromatin dispersion. The prevalence of varicocoele-related immune infertility is about 15% and does not depend on the grade of vein dilatation both in primary and secondary fertility disorders. Varicocoele is not an immediate cause of autoimmune reactions against spermatozoa, but is a cofactor increasing ASA risk; the OR of immune infertility after a testicular trauma in varicocoele patients increases twofold. In varicocoele patients, the autoimmune antisperm reaction is accompanied by a more significant decrease in the semen quality (concentration and number of progressively motile and morphologically normal spermatozoa in the ejaculate), acrosome reaction disorders (presence of pre-term spontaneous and lack of induced reactions) and an increase in the proportion of spermatozoa with DNA fragmentation. These disorders correlate with the level of sperm oxidative stress; reactive oxygen species (ROS) production in ASA-positive varicocoele patients is 2.8 and 3.5 times higher than in ASA-negative varicocoele patients and fertile men respectively. We did not find correlation between the grade of spermatic cord vein dilatation and ROS production.

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Sperm Antibodies and Assisted Reproduction

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Aly

2016

Immune Infertility

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Sperm Functions Influenced by Immune Reactions

Cited by 6 publications

References 68 publications

The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

Male fertility and varicocoele: role of immune factors

Sperm Antibodies and Assisted Reproduction

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