Sperm Motility, Oxidative Status, and Mitochondrial Activity: Exploring Correlation in Different Species

Gallo, Alessandra; Esposito, Maria Consiglia; Tosti, Elisabetta; Boni, Raffaele

doi:10.3390/antiox10071131

Cited by 41 publications

(29 citation statements)

References 45 publications

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“…Another explanation could be that Proline catabolism captures energy for the cells under nutrient depletion conditions, thereby protecting mitochondrial function (Tanner, 2019). The energy status and motility of spermatozoa are linked to mitochondrial activity (Bulkeley et al, 2021; Gallo et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of L‐ Proline supplementation on the quality of human spermatozoa

Moradi

Hashemian

et al. 2022

Andrologia

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L-Proline is a natural anti-oxidative and osmoprotectant agent, playing a versatile role in cell metabolism and physiology. The present study aimed to explore the antioxidant effects of L-Proline on human sperm function during incubation. Thirty healthy, normozoospermic men (27-40 years) were enrolled. Sperm samples were incubated in an unsupplemented sperm medium (control group), or supplemented with L-Proline (1, 2 and 4 mmol/L) to evaluate its effect during 0, 1, 4 and 24 h of incubation. Sperm were assessed in terms of motility, viability, morphology, chromatin and DNA integrity. Moreover, the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined in the sperm medium. The results indicated that 2 mmol/L of L-Proline significantly improved the maintenance of sperm motility, viability, normal morphology, chromatin and DNA integrity, and TAC levels compared to the control group during 24 h of incubation (p < 0.05). However, 1 and 4 mmol/L of L-Proline could not significantly preserve sperm parameters, chromatin quality, and antioxidant status during different incubation times compared to the control group (p > 0.05). Collectively, the inclusion of L-Proline (2 mmol/L) in the human sperm medium maintains sperm parameters and chromatin quality probably by modulating the oxidative status.

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Section: Discussionmentioning

confidence: 99%

Beneficial effect of L‐ Proline supplementation on the quality of human spermatozoa

Moradi

Hashemian

et al. 2022

Andrologia

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“…[14][15][16] The mechanism of MSG as an Antioxidants can increase the motility of spermatozoa that have been exposed to oxidants. [17][18][19] Consuming MSG continuously at excessive doses can increase levels of free radicals that can cause oxidative stress. Physiologically, ROS is produced during the spermatogenesis process, but its presence must be neutralized with antioxidants.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Combination of Green Tea and Roselle Extract on Morphology and Motility of Spermatozoa in Rats Induced by Monosodium Glutamate

Adinugroho¹,

Prasetyo

Nugroho

2022

Bioscmed

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Background: Infertility is a reproductive system problem and has been increasing recently. One of the reasons is the poor quality of spermatozoa, which can be assessed through its morphology and motility. Excessive consumption of MSG can affect the quality of spermatozoa. The provision of a combination of green tea and roselle extract, which is an antioxidant and is expected to be able to counteract the effects of MSG’s free radicals on spermatozoa. The objective of the study is to determine the morphology and motility of Wistar Rats’ spermatozoa in the control group given MSG and in the experimental group given MSG and a combination of green tea and roselle extract at a dose of 200 mg/kg/day and 400 mg/kg/day for 14 days. Methods: Fifteen Wistar rats were randomly divided into three groups, a control group with MSG, group 1 with MSG and a combination of green tea and roselle extract at a dose of 200 mg/kg BW/day (P1), and group 2 with MSG and combination green tea and roselle extract at a dose of 400 mg/kg BW/day (P2). After 14 days of treatment, the morphology and motility of the spermatozoa of each mouse were studied and assessed microscopically. Results: In the morphological study, the control group had the lowest normal value and the highest abnormal value among all groups. Meanwhile, the P1 group had the highest normal and lowest abnormal values compared to the other two groups. Conclusion: The administration of a combination of green tea and roselle extract improved the morphology and motility of Wistar rats’ spermatozoa. However, an increased dose of a combination of green tea and roselle extract was not proven to affect the morphology and motility of Wistar rats' spermatozoa.

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“…Mayer and Bukau [25] showed that the hydrolysis of ATP is significant for the protein chaperone HSP70. The sperm motility and complex mitochondrial respiratory activity are positively correlated [87]. When sperm lack energy to survive, their motility can diminish.…”

Section: Effect Of Freezing-thawing On the Functioning Mechanism Of H...mentioning

confidence: 99%

Implications of sperm heat shock protein 70-2 in bull fertility

et al. 2022

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Heat shock protein 70 (HSP70) is one of the most abundant chaperone proteins. Their function is well documented in facilitating the protein synthesis, translocation, de novo folding, and ordering of multiprotein complexes. HSP70 in bovine consists of four genes: HSP70-1, HSP70-2, HSP70-3, and HSP70-4. HSP70-2 was found to be involved in fertility. Current knowledge implicates HSP70-2 in sperm quality, sperm capacitation, sperm–egg recognition, and fertilization essential for bull reproduction. HSP70-2 is also involved in the biological processes of spermatogenesis, as it protects cells from the effects of apoptosis and oxidative stress. Fertilization success is not only determined by the amount of sperm found in the female reproductive tract but also by the functional ability of the sperm. However, subfertility is more likely to be associated with changes in sperm molecular dynamics not detectable using conventional methods. As such, molecular analyses and omics methods have been developed to monitor crucial aspects of sperm molecular morphology that are important for sperm functions, which are the objectives of this review.

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Sperm Motility, Oxidative Status, and Mitochondrial Activity: Exploring Correlation in Different Species

Cited by 41 publications

References 45 publications

Beneficial effect of L‐ Proline supplementation on the quality of human spermatozoa

Beneficial effect of L‐ Proline supplementation on the quality of human spermatozoa

The Effect of Combination of Green Tea and Roselle Extract on Morphology and Motility of Spermatozoa in Rats Induced by Monosodium Glutamate

Implications of sperm heat shock protein 70-2 in bull fertility

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