Sperm Parameters before and after Swim-Up of a Second Ejaculate after a Short Period of Abstinence

Manna, Claudio; Barbagallo, Federica; Manzo, Raffaella; Rahman, Ashraf Farrag; Francomano, Davide; Calogero, Aldo E.

doi:10.3390/jcm9041029

Cited by 22 publications

(52 citation statements)

References 32 publications

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“…The increases in total and progressive motility were particularly important demonstrating that, despite a decrease in volume, subsequent samples showed a significant increase in sperm motility and morphology. These results confirm previous data obtained after a short abstinence in subfertile males and confirm that the second sample provides a source of progressive motile spermatozoa to be used alone or in addition to the first one 14,29 . Furthermore, data showed that the second sample was utilized more frequently than the combination of both samples and just the first one.…”

Section: Discussionsupporting

confidence: 90%

“…These results confirm previous data obtained after a short abstinence in subfertile males and confirm that the second sample provides a source of progressive motile spermatozoa to be used alone or in addition to the first one. 14,29 Furthermore, data showed that the second sample was utilized more frequently than the combination of both samples and just the first one. The choice of which sample to utilize for ICSI was based mainly on progressive motile spermatozoa.…”

Section: Ta B L E 3 Total and Relative Results Of The Two Groupsmentioning

confidence: 99%

“…However, the results are controversial. For example, some researchers have reported that SARS-CoV-2 was not detected in the male reproductive tract, [25][26][27][28][29][30][31][32][33][34] while others reported that SARS-CoV-2 RNA was found in the semen or testes of COVID-19 patients. 35,36 There are also unknown factors regarding COVID-19 and male reproduction.…”

Section: Introductionmentioning

confidence: 99%

“…The positive correlation between abstinence length, DNA fragmentation and sperm quality could be explained by the prolonged exposure to ROS from dead spermatozoa and leukocytes. 25,29,[31][32][33] The shortening of abstinence time with frequent ejaculations may reduce the deleterious effect of excessive exposure to ROS, in particular, in OAT patients. 33 The underlying mechanisms are still unclear.…”

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confidence: 99%

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Two subsequent seminal productions: A good strategy to treat very severe oligoasthenoteratozoospermic infertile couples

et al. 2021

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Background: Sexual abstinence is considered one of the several factors that influence sperm quality. Recent studies show that a shortening of the abstinence period could be beneficial mostly in oligoasthenoteratozoospermic (OAT) patients.Objective: Retrospective study to verify the efficacy of a second semen sample after a short abstinence to treat severe OAT infertile patients.Materials and methods: 127 couples treated between May 2014 and May 2018 were divided into two groups. Study Group 1 (75 cycles): severe OAT characteristics: count <0.2 × 10 6 /mL no progressive motility; count ≥0.2 × 10 6 /mL and no total or progressive motility; 0% normal morphology; a second semen sample was requested after abstinence of 2 h. Control Group 0 (52 cycles): normozoospermic or mild OAT; only one sample was requested. Intracytoplasmic sperm injection was utilized in all cases.Results: All semen parameters were significantly different between Group 0 vs both samples of Group 1 (p < 0.001), excluding volume between Group 0 and 1st sample of Group 1 (p = 0.682). The comparison between 1st and 2nd samples from Group 1 showed significant differences in volume, total and progressive motility and morphology (p < 0.001, p < 0.001, p < 0.020) but not in total sperm count (p = 0.970).Fertilization, pregnancy rate/transfer, implantation and miscarriage rates were 85.9% and 61.1% (p < 0.001), 30.6% and 35.8% (p = 0.700), 17.5% and 24.0 (p = 0.292), 20.0% and 25.0% (p = 0.017) in Group 0 and Group 1 respectively. Discussion and conclusion:The results show that a short abstinence in severe OAT patients allows us to obtain spermatozoa with better motility. The request for a second semen sample in couples with extreme semen parameters is a valid and simple strategy that helps to achieve the same probability of pregnancy compared to a Control Group. Furthermore, it allows us to utilize fresh spermatozoa avoiding the need to resort to cryopreserved reserves or testicular surgery.

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Section: Discussionsupporting

confidence: 90%

Section: Ta B L E 3 Total and Relative Results Of The Two Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Two subsequent seminal productions: A good strategy to treat very severe oligoasthenoteratozoospermic infertile couples

et al. 2021

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“…A growing number of studies are focusing their attention on the possibility of using a second ejaculate collected after a very short period of abstinence in infertile men, especially patients with oligo-asthenozoospermia (OA). We previously reported that a second consecutive ejaculate (collected within 1 h from the first) resulted in better conventional sperm parameters (motility and morphology) and a lower percentage of spermatozoa with fragmented DNA in normozoospermic male partners of infertile couples and even more in patients with OAT [ 16 ]. Our findings were in line with the most recent literature [ 4 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Does a Very Short Length of Abstinence Improve Assisted Reproductive Technique Outcomes in Infertile Patients with Severe Oligo-Asthenozoospermia?

Barbagallo

Calogero

Condorelli

et al. 2021

JCM

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In recent years, a growing number of studies seem to support the beneficial effects of a very short abstinence period on sperm parameters, especially in patients with oligo-asthenozoospermia (OA). On this basis, the aim of this study was to evaluate the effects of a short period of abstinence (1 h) on intracytoplasmic sperm injection (ICSI) outcomes in infertile patients with severe OA. We performed a retrospective study on 313 ICSI cycles in which couples were divided into two different groups based on sperm parameters of the male partners. Group 1 included normozoospermic men or male partners with a mild OA (n = 223). Group 2 included male partners with severe OA (n = 90). They were asked to provide a second consecutive ejaculation after 1 h from the first one. The best ejaculate was used to perform ICSI. We found a significant increase of total (p < 0.001) and progressive motility (p < 0.001) in the second ejaculate of patients of Group 2 compared with those of the first one. Spermatozoa of the second ejaculate were chosen for ICSI for all patients in Group 2. We found statistically significant improvement of clinical pregnancy rate (p = 0.001) and embryo quality (p = 0.003) in couples in Group 2 compared to those of Group 1. No statistically significant difference was found in fertilization, implantation, live birth delivery, and miscarriage rates between the two groups. Therefore, a second semen sample collected after a very short time-interval in patients with severe OA allowed us to obtain significantly higher clinical pregnancy rate with improved embryo quality compared to normozoospermic men or patients with mild OA. Fertilization, implantation, live birth delivery, and miscarriage rates were similar between the two groups. The present study shows that a second consecutive ejaculate could represent a simple strategy to obtain better sperm parameters and assisted reproductive technology (ART) outcomes in infertile patients with mild-severe OA.

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Relation between semen oxidative reduction potential in initial semen examination and IVF outcomes

Tomita

Udayanga

Satoh

et al. 2023

Reprod Medicine & Biology

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Purpose The MiOXSYS system is a new technique to analyze the semen oxidative reduction potential (ORP) that may use to classify the level of sperm DNA integrity. It does not clearly explain how the semen ORP values could help to change the IVF outcomes. We have analyzed correlations between semen ORP value and the IVF results. Methods Four hundred and thirty couples were enrolled. The male counterparts were divided into two groups according to their semen ORP values and compared the fertilization rate, cell cleavage rate, and embryo quality, following the IVF procedures. The relations between ORP values and the clinical pregnancy, live birth, and abortion rates were analyzed. Results The ORP values show negative and positive correlations with some conventional semen parameters. The fertilization and the cleavage rate did not show any differences in those two groups, but the transferable embryo rate was significantly high in patients with high semen ORP. However, the patients with high ORP show a tendency to lower clinical pregnancy with a low abortion rate compared to the low ORP group. Conclusion The main purpose of measuring the ORP value in semen is still questionable and shows controversial results.

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Sperm Parameters before and after Swim-Up of a Second Ejaculate after a Short Period of Abstinence

Cited by 22 publications

References 32 publications

Two subsequent seminal productions: A good strategy to treat very severe oligoasthenoteratozoospermic infertile couples

Two subsequent seminal productions: A good strategy to treat very severe oligoasthenoteratozoospermic infertile couples

Does a Very Short Length of Abstinence Improve Assisted Reproductive Technique Outcomes in Infertile Patients with Severe Oligo-Asthenozoospermia?

Relation between semen oxidative reduction potential in initial semen examination and IVF outcomes

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