2020
DOI: 10.22270/ajprd.v8i3.727
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Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

Abstract: A greater challenge in solid dosage formulation is the development of spherical agglomerates which increases the solubility and bioavailability of the drug. Spherical crystallization is “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. Direct Compression of powders … Show more

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Cited by 3 publications
(3 citation statements)
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“…The association of molecules in a solid state, which might impact the physical and chemical properties of the medicinal substance, is referenced by the crystal form. [8] The effectiveness of a dose shape may depend on the crystal structure, especially for substances that naturally impede drug delivery. [9] Pharmaceutical drug manufacture and storage may result in changes to a drug's crystal structure, which can impact the medication's solubility, dissolution profile, and bioavailability.…”
Section: Lipophilicitymentioning
confidence: 99%
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“…The association of molecules in a solid state, which might impact the physical and chemical properties of the medicinal substance, is referenced by the crystal form. [8] The effectiveness of a dose shape may depend on the crystal structure, especially for substances that naturally impede drug delivery. [9] Pharmaceutical drug manufacture and storage may result in changes to a drug's crystal structure, which can impact the medication's solubility, dissolution profile, and bioavailability.…”
Section: Lipophilicitymentioning
confidence: 99%
“…For instance, to increase their soluble nature and bioavailability in the alkaline environment of the small intestine, acidic substances may be prepared as salts containing significant counterions. [8] Other methods may be used in addition to pH modification to increase the bioavailability of oral medications that are poorly soluble. These techniques consist of solid dispersion, lipid formation, co-crystal creation, and nanosuspension.…”
Section: Chemical Alterations Ph Correctionmentioning
confidence: 99%
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