Spike detection in human muscle sympathetic nerve activity using a matched wavelet approach

Salmanpour, Aryan; Brown, Lyndon J.; Shoemaker, J. Kevin

doi:10.1016/j.jneumeth.2010.08.035

Cited by 72 publications

(88 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The approach used in the current study, while unable to track the firing patterns of single axons, emphasizes the patterns of activity in all APs comprising the burst, with information regarding the size of each AP and the appearance of new and larger APs on a burst-by-burst basis. The potential problem of complete overlap and summation of concurrent spikes has been established in this approach (25), being Ͻ1% and apparent summated APs are deleted. Thus, the method offers the opportunity to observe the presence of different sizes of APs and their firing probabilities.…”

Section: Discussionmentioning

confidence: 99%

“…Burst size was expressed as burst integral (amplitude ϫ duration/2) and normalized to the largest burst in sinus rhythm. APs were detected and extracted from the filtered raw MSNA signal using techniques reported previously (2,25,26,30). Briefly, this technique uses a continuous wavelet transform (CWT) for AP detection.…”

Section: Subjectsmentioning

confidence: 99%

“…Briefly, this technique uses a continuous wavelet transform (CWT) for AP detection. The CWT uses a "mother wavelet" adapted to an average AP waveform constructed from (and hence with the same peak-to-peak amplitude as) physiological recordings of postganglionic sympathetic APs in our laboratory (25). The CWT is applied to the filtered MSNA to provide a wavelet coefficient between the signal of interest (i.e., an action potential) and the mother wavelet, such that the largest wavelet coefficient occurs in the presence of the APs, but negligible coefficients occur when applied to noise.…”

Section: Subjectsmentioning

confidence: 99%

See 2 more Smart Citations

Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls

Maslov

Brešković

Brewer

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Premature ventricular contractions (PVC) elicit larger bursts of multiunit muscle sympathetic nerve activity (MSNA), reflecting the ability to increase postganglionic axonal recruitment. We tested the hypothesis that chronic heart failure (CHF) limits the ability to recruit postganglionic sympathetic neurons as a response to PVC due to the excessive sympathetic activation in these patients. Sympathetic neurograms of sufficient signal-to-noise ratio were obtained from six CHF patients and from six similarly aged control individuals. Action potentials (APs) were extracted from the multiunit sympathetic neurograms during sinus rhythm bursts and during the post-PVC bursts. These APs were classified on the basis of the frequency per second, the content per burst, and the peak-to-peak amplitude, which formed the basis of binning the APs into active clusters. Compared with controls, CHF had higher APs per burst and higher number of active clusters per sinus rhythm burst (P < 0.05). Compared with sinus rhythm bursts, both groups increased AP frequency and the number of active clusters in the post-PVC burst (P < 0.05). However, compared with controls, the increase in burst integral, AP frequency, and APs per burst during the post-PVC burst was less in CHF patients. Nonetheless, the PVC-induced increase in active clusters per burst was similar between the groups. Thus, these CHF patients retained the ability to recruit larger APs but had a diminished ability to increase overall AP content.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

See 1 more Smart Citation

Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls

Maslov

Brešković

Brewer

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Therefore, increased firing probability of already recruited axons may be a primary mechanism by which sympathetic activation is achieved (175), and by extension, neurovascular control is affected. More recently, signal processing techniques have been adapted in the study of sympathetic neural recordings to detect and extract multiunit action potentials within the filtered MSNA signal (41,74,235,277). These multiunit spike train methods indicate that during both rest and sympathoexcitatory states, action potential latencies decrease, and action potential concentration increases, during elevations in burst strength (309).…”

Section: Characteristics Of Postganglionic Sympathetic Dischargementioning

confidence: 99%

“…Following the work of Diedrich and colleagues (74), our laboratory developed a wavelet-based approach (235) to enhance detection and morphological classification of the multiunit firing properties of sympathetic neurons. With this approach Steinback et al (266) reported higher firing rates of axons already active at baseline, as well as the recruitment of latent, higher threshold, and faster conducting sympathetic axons, during chemoreflex activation induced via prolonged breath holds (Fig.…”

Section: Characteristics Of Postganglionic Sympathetic Dischargementioning

confidence: 99%

Neural Control of Vascular Function in Skeletal Muscle

Shoemaker

Badrov

Al‐Khazraji

et al. 2015

Comprehensive Physiology

View full text Add to dashboard Cite

The sympathetic nervous system represents a fundamental homeostatic system that exerts considerable control over blood pressure and the distribution of blood flow. This process has been referred to as neurovascular control. Overall, the concept of neurovascular control includes the following elements: efferent postganglionic sympathetic nerve activity, neurotransmitter release, and the end organ response. Each of these elements reflects multiple levels of control that, in turn, affect complex patterns of change in vascular contractile state. Primarily, this review discusses several of these control layers that combine to produce the integrative physiology of reflex vascular control observed in skeletal muscle. Beginning with three reflexes that provide somewhat dissimilar vascular patterns of response despite similar changes in efferent sympathetic nerve activity, namely, the baroreflex, chemoreflex, and muscle metaboreflex, the article discusses the anatomical and physiological bases of postganglionic sympathetic discharge patterns and recruitment, neurotransmitter release and management, and details of regional variations of receptor density and responses within the microvascular bed. Challenges are addressed regarding the fundamentals of measurement and how conclusions from one response or vascular segment should not be used as an indication of neurovascular control as a generalized physiological dogma. Whereas the bulk of the article focuses on the vasoconstrictor function of sympathetic neurovascular integration, attention is also given to the issues of sympathetic vasodilation as well as the impact of chronic changes in sympathetic activation and innervation on vascular health. © 2016 American Physiological Society.

show abstract

Sympathetic Neural Activity to the Cardiovascular System: Integrator of Systemic Physiology and Interindividual Characteristics

Charkoudian

Wallin

2014

Comprehensive Physiology

116

View full text Add to dashboard Cite

The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascular function with a focus on integrative mechanisms in humans. Direct measurement of sympathetic neural activity (SNA) in humans can be accomplished using microneurography, most commonly performed in the peroneal (fibular) nerve. In humans, muscle SNA (MSNA) is composed of vasoconstrictor fibers; its best-recognized characteristic is its participation in transient, moment-to-moment control of arterial blood pressure via the arterial baroreflex. This property of MSNA contributes to its typical "bursting" pattern which is strongly linked to the cardiac cycle. Recent evidence suggests that sympathetic neural mechanisms and the baroreflex have important roles in the long term control of blood pressure as well. One of the striking characteristics of MSNA is its large interindividual variability. However, in young, normotensive humans, higher MSNA is not linked to higher blood pressure due to balancing influences of other cardiovascular variables. In men, an inverse relationship between MSNA and cardiac output is a major factor in this balance, whereas in women, beta-adrenergic vasodilation offsets the vasoconstrictor/pressor effects of higher MSNA. As people get older (and in people with hypertension) higher MSNA is more likely to be linked to higher blood pressure. Skin SNA (SSNA) can also be measured in humans, although interpretation of SSNA signals is complicated by multiple types of neurons involved (vasoconstrictor, vasodilator, sudomotor and pilomotor). In addition to blood pressure regulation, the sympathetic nervous system contributes to cardiovascular regulation during numerous other reflexes, including those involved in exercise, thermoregulation, chemoreflex regulation, and responses to mental stress.

show abstract

Spike detection in human muscle sympathetic nerve activity using a matched wavelet approach

Cited by 72 publications

References 55 publications

Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls

Recruitment pattern of sympathetic muscle neurons during premature ventricular contractions in heart failure patients and controls

Neural Control of Vascular Function in Skeletal Muscle

Sympathetic Neural Activity to the Cardiovascular System: Integrator of Systemic Physiology and Interindividual Characteristics

Contact Info

Product

Resources

About