Spin density projection‐assisted R2 magnetic resonance imaging of the liver in the management of body iron stores in patients receiving multiple red blood cell transfusions: an audit and retrospective study in South Australia

Brown, G. A.; Patton, W. N.; Tapp, Heather; Taylor, D. J.; Pierre, Timothy G. St.

doi:10.1111/j.1445-5994.2012.02845.x

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…The clinical utility of regular MRI measurements is not simply to determine the degree of iron loading, but to use this information to make informed, data‐driven decisions about initiation and adjustment of chelation therapy. Indeed, increasing use of MRI to guide chelation therapy in patients with thalassemia has contributed to reduced iron burden …”

Section: Clinical Application Of Mri Assessmentsmentioning

confidence: 99%

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MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls

Quinn

Pierre

2015

Pediatr Blood Cancer

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Magnetic resonance imaging (MRI) has played a key role in studies of iron overload in transfusion‐dependent patients, providing insights into the relations among liver and cardiac iron loading, iron chelator dose, and morbidity. Currently, there is rapid uptake of these methods into routine clinical practice as part of the management strategy for iron overload in regularly transfused patients. Given the manifold methods of data acquisition and analysis, there are several potential pitfalls that may result in inappropriate decision making. Herein, we review the challenges of establishing suitable MRI techniques for tissue iron measurement in regularly transfused patients.

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Section: Clinical Application Of Mri Assessmentsmentioning

confidence: 99%

“…Indeed, increasing use of MRI to guide chelation therapy in patients with thalassemia has contributed to reduced iron burden. [50,51]…”

Section: Clinical Application Of Mri Assessmentsmentioning

confidence: 99%

MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls

Quinn

Pierre

2015

Pediatr Blood Cancer

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A USPIO doped gel phantom for R2* relaxometry

Brown

Cowin

Galloway

2016

Magn Reson Mater Phy

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Assessing the accuracy of CMRtools software for diagnosing liver iron overload in thalassemia patients: influencing factors and optimisation strategies

Luo,

Peng,

et al. 2024

Front. Med.

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BackgroundCMRtools is a software package that can be used to measure T2* values to diagnose liver iron overload, however, its accuracy in terms is affected by multiple factors, including goodness-of-fit (R2 value), the number of echo time (TE) images, and the liver iron concentration (LIC). To investigate the effects of the R2 value, the number of TE images, and the LIC on the accuracy of CMRtools software for measuring T2* values to diagnose liver iron overload (LIO).Materials and methodsCMRtools software was used to measure liver T2* values among 108 thalassemia patients via the truncation method, and the R2 values, the number of TE images, and T2* values were recorded. These values were subsequently converted into liver iron concentration (LICT) values. The LICF (derived from MRI-R2/FerriScan) was used as a reference, and the diagnostic accordance rate (DAR) was compared between R2 value subgroups, between TE image number subgroups, and between LIC subgroups.ResultsThe greater the R2 value was, the greater the standardized DAR (SDAR) was (p < 0.05). The SDAR are not identical between each TE image number subgroup (p > 0.05). However, the relationship between TE image number subgroups and SDAR was analysed using Spearman’s correlation, and it was found to be positively correlated (rs = 0.729, p = 0.017). The SDAR are not identical between each LIC subgroup (p > 0.05), furthermore, the relationship between LIC subgroup and SDAR was found irrelevant (p = 0.747).ConclusionThe accuracy of CMRtools software for diagnosing LIO in patients with thalassemia can be improved by artificially controlling the number of TE images to be fitted and selecting higher R2 values.

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Spin density projection‐assisted R2 magnetic resonance imaging of the liver in the management of body iron stores in patients receiving multiple red blood cell transfusions: an audit and retrospective study in South Australia

Abstract: The data are consistent with previous observations that introduction of non-invasive monitoring of LIC can contribute to a decreased body iron burden through improved clinical decision making and improved feedback to patients and hence improved adherence to chelation therapy.

Cited by 3 publications

References 18 publications

MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls

MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls

A USPIO doped gel phantom for R2* relaxometry

Assessing the accuracy of CMRtools software for diagnosing liver iron overload in thalassemia patients: influencing factors and optimisation strategies

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