Spinal cord compression in relation to clinical symptoms in patients with spinal meningiomas

Corell, Alba; Cerbach, C.; Hoefling, Nickoleta; Björkman–Burtscher, Isabella M.; Jakola, Asgeir Store

doi:10.1016/j.clineuro.2021.107018

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…Information on spinal cord compression or tumor occupancy of the spinal canal with overall mean, median, or range values were presented in 13 studies [ 3 , 4 , 28 , 56 , 58 , 60 , 63 , 65 , 67 , 68 , 69 , 70 , 71 ]. The studies reported spinal cord compression to varying degrees and while the definitions of mild, moderate, or severe spinal cord compression varied between studies, the distribution between the categories were similar.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, two studies analyzed the relation between compression and symptomatology. While one of them found a positive correlation between the degree of spinal cord compression and the occurrence of both motor and gait disturbances separately [ 69 ], the other found no correlations [ 65 ]. The former study also demonstrated a higher correlation between tumor occupancy, rather than spinal cord compression, and motor, gait, and bladder or bowel deficits [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

“…While one of them found a positive correlation between the degree of spinal cord compression and the occurrence of both motor and gait disturbances separately [ 69 ], the other found no correlations [ 65 ]. The former study also demonstrated a higher correlation between tumor occupancy, rather than spinal cord compression, and motor, gait, and bladder or bowel deficits [ 69 ]. A significant tumor occupancy cutoff value of 65% was proposed to indicate increased prevalence of symptoms [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

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Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

El-Hajj

Pettersson-Segerlind

Fletcher‐Sandersjöö

et al. 2022

Cancers

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Background: Spinal meningiomas are the most common primary intradural spinal tumors. Although they are a separate entity, a large portion of the knowledge on spinal meningiomas is based on findings in intracranial meningiomas. Therefore, a comprehensive review of all the literature on spinal meningiomas was performed. Methods: Electronic databases were searched for all studies on spinal meningiomas dating from 2000 and onward. Findings of matching studies were pooled to strengthen the current body of evidence. Results: A total of 104 studies were included. The majority of patients were female (72.83%), elderly (peak decade: seventh), and had a world health organization (WHO) grade 1 tumor (95.7%). Interestingly, the minority of pediatric patients had a male overrepresentation (62.0% vs. 27.17%) and higher-grade tumors (33.3% vs. 4.3%). Sensory and motor dysfunction and pain were the most common presenting symptoms. Despite a handful of studies reporting promising findings associated with the use of non-surgical treatment options, the literature still suffers from contradictory results and limitations of study designs. Conclusions: Elderly females with WHO grade 1 tumors constituted the stereotypical type of patient. Compared to surgical alternatives, the evidence for the use of non-surgical treatments is still relatively weak.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

El-Hajj

Pettersson-Segerlind

Fletcher‐Sandersjöö

et al. 2022

Cancers

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“…( 10 ) Since the MAC-score partly rests on the mMCs data, and only patients with preoperative symptoms can improve, this finding becomes self-evident. In addition, two previously published studies found that the improvement in mMCs was correlated to the degree of spinal cord compression rather than MIB-1 index, ( 4 , 6 ) and age, sex, tumor location, and MIB-1 index all failed to significantly correlate with postoperative mMCs improvement. ( 4 ).…”

Section: Discussionmentioning

confidence: 87%

“…( 4 ) The functional status in these patients is usually assessed using standardized methods, such as the modified McCormick scale (mMCS) ( Table 1 ). ( 4 – 6 ) Tumor proliferation markers, like the MIB-1 index, are also often used to assess the growth fraction of the tumor cells. Although previous studies are scarce, spinal meningiomas tend to have low MIB-1 indices ( 7 – 9 ) and there is no consensus on a specific MIB-1 index cut-off value for the prediction of tumor progression or recurrence in spinal meningiomas.…”

Section: Introductionmentioning

confidence: 99%

Unsuccessful external validation of the MAC-score for predicting increased MIB-1 index in patients with spinal meningiomas

et al. 2022

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ObjectiveRecently, the MAC-spinal meningioma score (MAC-score) was proposed to preoperatively identify spinal meningioma patients with high MIB-1 indices. Risk factors were age ≥ 65 years, a modified McCormick score (mMCs) ≥ 2, and absence of tumor calcification. The aim of this study was to externally validate the MAC-score in an independent cohort.MethodsUsing the same inclusion and exclusion criteria as in the original study, we performed a retrospective, single-center, population-based, cohort study that included patients who had undergone surgical treatment for spinal meningiomas between 2005 – 2017. Data was collected from patient charts and radiographic images. Validation was performed by applying the MAC-score to our cohort and evaluating the area under the receiver operating characteristic curve (AUC).ResultsIn total, 108 patients were included. Baseline and outcome data were comparable to the original development study. An increased MIB-1 index (≥5%) was observed in 56 (52%) patients. AUC of the MAC-score in our validation cohort was 0.61 (95% CI: 0.51 – 0.71), which corresponds to a poor discriminative ability.ConclusionThe MAC-score showed poor discriminative ability for MIB-1 index prediction in patients with spinal meningiomas. Moreover, the MAC-score rests on a weak theoretical and statistical foundation. Consequently, we argue against its clinical implementation.

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Functional outcome after introduction of hemilaminectomy in management of spinal schwannomas and meningiomas

Muncan,

Klurfan,

Rymond

et al. 2024

Heliyon

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Spinal cord compression in relation to clinical symptoms in patients with spinal meningiomas

Cited by 12 publications

References 30 publications

Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

Unsuccessful external validation of the MAC-score for predicting increased MIB-1 index in patients with spinal meningiomas

Functional outcome after introduction of hemilaminectomy in management of spinal schwannomas and meningiomas

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