Spinal cord compression resulting from Burkitt's lymphoma in children

Dechambenoit, Gilbert; Piquemal, M.; Giordano, Christian; C, Cournil; Zeze, V. Ba; Santini, J

doi:10.1007/bf00301252

Cited by 20 publications

(15 citation statements)

References 14 publications

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“…Boggan reported that surgical treatment should be limited to the cases based on the severity and chronicity of preoperative damage (19). In contrast, the improvement of pituitary abscess only with medication consisting of administration of CTX and metronidazol for 1 month and netilmicin for 15 days was also reported (20) …”

Section: Causes Of Pituitary Abscess Have Been Suggested As Follows: mentioning

confidence: 97%

Successful Treatment of Pituitary Abscess with Oral Administration of Sparfloxacin

et al. 2008

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Pituitary abscess is a rare infection and it is difficult to make the correct diagnosis. It is usually treated by a combination of surgical drainage and intravenous administration of antibiotics. We describe a 74-year-old woman with recurrent meningo-encephalitis due to pituitary abscess. The abscess increased in size in spite of the intravenous administration of panipenem/betamipron (PAPM/BP), clindamycin (CLDM) and chloramphenicol (CP). Finally she was successfully treated with oral administration of sparfloxacin (SPFX) without operation.

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Section: Causes Of Pituitary Abscess Have Been Suggested As Follows: mentioning

confidence: 97%

Successful Treatment of Pituitary Abscess with Oral Administration of Sparfloxacin

et al. 2008

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“…Furthermore, surgical intervention may delay the administration of systemic chemotherapy, the definitive treatment for BL. Surgery may be warranted for various complications that can be related to BL, such as intestinal perforation, bleeding, or obstruction, refractory gastric outlet obstruction, or spinal cord instability [62,63].…”

Section: Radiation Therapymentioning

confidence: 99%

Burkitt’s and Burkitt-like Lymphoma

Evens

Gordon

2002

Curr. Treat. Options in Oncol.

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Burkitt's and Burkitt-like lymphoma (BL/BLL) are aggressive B-cell malignancies with a high proliferative rate that may be fatal within months if not treated promptly. Furthermore, treatment of BL/BLL requires comprehensive supportive care to avoid disease-related complications such as acute renal failure secondary to tumor lysis syndrome. Improvements in our understanding of the biology of BL and BLL have led to more effective therapeutic protocols. Clinical trials have demonstrated that short duration, multi-agent, dose-intensive chemotherapy regimens combined with aggressive central nervous system therapy results in long-term survival rates in children and young adults near 70% to 80%, whereas long-term disease-free survival rates in older adults remains suboptimal at 15% to 25%. Outcomes in HIV-associated BL/BLL are improved because of more effective chemotherapy regimens and enhanced HIV care. Autologous bone marrow transplantation has proven feasible in many patient populations with BL/BLL and may lead to cure in selected patients. Improved therapeutic strategies are warranted, such as integrating agents such as monoclonal antibodies to combination dose-intensive chemotherapy. Moreover, further study into the molecular biology of BL/BLL with attention to the role of c-myc dysregulation is needed to help predict prognostic factors and for the development of molecular targeted therapies. Clinical trials remain critical to determine the most effective treatment regimens that will continue to improve cure rates in this aggressive but treatable disease.

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“…Laminectomy should only be considered when rapid deterioration under chemotherapy is observed. 14,15 Evidence to support this approach is also derived from studies of medullar compression due to neuroblastoma and tumoral metastases. 16,17 The reduced immunity in HIV-infected patients with lymphoma makes them more susceptible to the toxic effects of cytostatics, hence a higher risk exists of severe, lifethreatening infections during chemotherapy.…”

Section: Discussionmentioning

confidence: 97%

“…Polychemotherapy combining cyclophosphamide, methotrexate, vincristine, and cytarabine has been shown to be highly effective in most cases. 14 Serious complications such as hematoma, infection, cerebrospinal fluid fistula, nerve root damage, arachnoiditis, and spinal instability have been described after emergency laminectomies. 9 In view of evidence of the high sensitivity of the tumor to chemotherapy, a spinal compression due to Burkitt lymphoma is seen primarily as a nonsurgical disease.…”

Section: Discussionmentioning

confidence: 99%

Spinal Compression Due to Burkitt Lymphoma in a Newly Diagnosed HIV-infected Child

Stefan¹,

Toorn²,

Andronikou

2009

Journal of Pediatric Hematology/Oncology

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We describe a newly diagnosed HIV-infected child, without prior history of AIDS-defining disease, who presented with Burkitt lymphoma-related cauda equina syndrome that rapidly progressed to a flaccid paraplegia. Diagnosis was confirmed on biopsy and magnetic resonance imaging of the spine showed multiple epidural masses with involvement of several vertebral bodies, cord edema and compression of the cord and cauda equina. The child's immune status was relatively preserved and Epstein-Barr serology proved negative. Chemotherapy (LMB 89 modified protocol) was initiated immediately after histopathologic confirmation, together with highly active antiretroviral therapy. A follow-up magnetic resonance imaging 6 weeks later showed segmental cord atrophy at the site of previous edema despite complete resolution of all the epidural masses. Unfortunately, the child's neurologic state did not improve beyond the recovery of sphincter control and lower limb sensation. The patient is the first reported case of Burkitt lymphoma-related spinal cord compression as an initial AIDS-defining illness, in a 10-year-old child. The outcome of the case highlights the importance of early diagnosis and prompt treatment of this aggressive tumor to avoid permanent neurologic deficits.

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Spinal cord compression resulting from Burkitt's lymphoma in children

Cited by 20 publications

References 14 publications

Successful Treatment of Pituitary Abscess with Oral Administration of Sparfloxacin

Successful Treatment of Pituitary Abscess with Oral Administration of Sparfloxacin

Burkitt’s and Burkitt-like Lymphoma

Spinal Compression Due to Burkitt Lymphoma in a Newly Diagnosed HIV-infected Child

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