Spinal cord gliomas: A multi-institutional retrospective analysis

Abdel‐Wahab, May; Etuk, Blessing; Palermo, James; Shirato, Hiroki; Kresl, John J.; Yapıcıer, Özlem; Walker, Gail; Scheithauer, Bernd W.; Shaw, Edward G.; Lee, Charles; Curran, Walter J.; Thomas, Theresa Currier; Markoe, Arnold M.

doi:10.1016/j.ijrobp.2005.09.038

Cited by 122 publications

(82 citation statements)

References 35 publications

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“…Additional 19 articles dealing with IMSCTs also reported one or more prognostic factors of interest for astrocytoma patients and form the basis of this review as well (Table 3). One IMSCT study [2] is a follow-up of a previous one [1], only the latter was used in this review [2].…”

Section: Resultsmentioning

confidence: 99%

“…Results of a statistical analysis of age as a prognostic factor were reported in 15 studies [2,5,24,27,28,30,34,41,46,49,56,59,60,64,65] (Table 4). Of these, 13 were classified as category A, 8 failed to find a significant relationship between age and prognosis [2,24,28,30,34,46,56,59], as did one additional category B study [27].…”

Section: Agementioning

confidence: 99%

“…Of these, 13 were classified as category A, 8 failed to find a significant relationship between age and prognosis [2,24,28,30,34,46,56,59], as did one additional category B study [27]. Four category A studies reported increased age to negatively affect prognosis: Sandler et al [64] found patients with tumor recurrence to be older (mean 38 years, median 31 years) than those without recurrence (mean 19 years, median 17 years), furthermore the oldest three patients in his study all experienced recurrence within 1 year.…”

Section: Agementioning

confidence: 99%

“…Of these, nine were classified as category A, six failed to find a significant association between gender and prognosis [2,34,41,49,59,60], as did two additional category B studies [27,65]. Two category A [5].…”

Section: Gendermentioning

confidence: 99%

“…Statistical analysis reporting tumor location as a prognostic factor was reported in nine studies [2,24,27,28,30,34,49,51,52] (Table 8). Of these, five were classified as category A, four did not report any significant relationship between tumor location and outcome [24,28,30,34], only (8) 13 (100) 6 (46) (23) 39 (68) 10 (17) Minehan [49] found significantly ''increased'' survival in patients with thoracic spinal cord involvement.…”

Section: Tumor Locationmentioning

confidence: 99%

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Prognostic factors in intramedullary astrocytomas: a literature review

2009

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Astrocytomas affect a significant portion of patients with intramedullary tumors. These infiltratively growing tumors are treated by a variety of methods-biopsy and decompressive surgery, maximal safe resection, adjuvant oncological therapy. Also, numerous prognostic factors are reported in the literature. Better understanding of factors that influence prognosis may help in treatment planning with the goal of prolonging survival. We have thus undertaken an extensive literature review in order to define factors affecting prognosis. A total of 38 articles were studied. Only tumor grade was consistently reported as the major factor affecting prognosis. The influence of other clinical factors (age, gender, history length, functional status, tumor location or extent, syrinx or cyst presence) can be speculated upon, but cannot be assessed adequately from the available literature. For both low-and high-grade (HG) astrocytomas, maximal safe tumor resection should be the primary treatment objective but is often not feasible in contrast to other intramedullary and spinal neoplasms. Since the biological nature of spinal cord HG glioma is identical to that of the brain, the same treatment algorithm of maximal safe resection followed by concomitant radio-and chemotherapy would be sensible to implement.

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Section: Resultsmentioning

confidence: 99%