Spinal Cord Injury/Disorder Function, Affiliate Stigma, and Caregiver Burden in Turkey

Kuzu, Duygu; Perrin, Paul B.; Pugh, Mickeal

doi:10.1002/pmrj.12548

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…400 , 401 As a result, making a thorough clinical decision based on a number of clinical laboratory test signs and long-term follow-up is required rather than merely predicting the prognosis of patients based on the ASIA scale. 395 , 402 , 403 In addition, it should be noted that no studies have offered a molecular classification that can predict SCI risk and prognosis.…”

Section: Clinical Treatment and Researchmentioning

confidence: 99%

Spinal cord injury: molecular mechanisms and therapeutic interventions

Ren

et al. 2023

Sig Transduct Target Ther

170

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Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. In the past few decades, researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling, but the results have not been ideal. Recently, new pathological mechanisms of SCI, especially the interactions between immune and neural cell responses, have been revealed by single-cell sequencing and spatial transcriptome analysis. With the development of bioactive materials and stem cells, more attention has been focused on forming intermediate neural networks to promote neural regeneration and neural circuit reconstruction than on promoting axonal regeneration in the corticospinal tract. Furthermore, technologies to control physical parameters such as electricity, magnetism and ultrasound have been constantly innovated and applied in neural cell fate regulation. Among these advanced novel strategies and technologies, stem cell therapy, biomaterial transplantation, and electromagnetic stimulation have entered into the stage of clinical trials, and some of them have already been applied in clinical treatment. In this review, we outline the overall epidemiology and pathophysiology of SCI, expound on the latest research progress related to neural regeneration and circuit reconstruction in detail, and propose future directions for SCI repair and clinical applications.

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Section: Clinical Treatment and Researchmentioning

confidence: 99%

Spinal cord injury: molecular mechanisms and therapeutic interventions

Ren

et al. 2023

Sig Transduct Target Ther

170

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“…770, p < 0.001), family relationships (r = −0.466, p = 0.009), and overall living standards (r = −0.646, p < 0.001). Kuzu et al [ 30 ] analyzed the direct and indirect effects of depression of the caregiver of a patient with SCI, the function of the patient with SCI, the stigma on the patient’s family due to the disability, and the burden of care. In that study, it was found that caregiver burden had a negative correlation with SCI patients’ residual function (r = −0.24, p < 0.01), a positive correlation with affiliate stigma (r = 0.36, p < 0.05), and a positive correlation with caregiver depression (r = 0.51, p < 0.01) [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Kuzu et al [ 30 ] analyzed the direct and indirect effects of depression of the caregiver of a patient with SCI, the function of the patient with SCI, the stigma on the patient’s family due to the disability, and the burden of care. In that study, it was found that caregiver burden had a negative correlation with SCI patients’ residual function (r = −0.24, p < 0.01), a positive correlation with affiliate stigma (r = 0.36, p < 0.05), and a positive correlation with caregiver depression (r = 0.51, p < 0.01) [ 30 ]. In our study, the proportion of participants who answered that the burden of care was mainly economic was high, which is different from the study by Kuzu et al [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In that study, it was found that caregiver burden had a negative correlation with SCI patients’ residual function (r = −0.24, p < 0.01), a positive correlation with affiliate stigma (r = 0.36, p < 0.05), and a positive correlation with caregiver depression (r = 0.51, p < 0.01) [ 30 ]. In our study, the proportion of participants who answered that the burden of care was mainly economic was high, which is different from the study by Kuzu et al [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Factor Analysis Affecting Degree of Depression in Family Caregivers of Patients with Spinal Cord Injury: A Cross-Sectional Pilot Study

Lee

Kim

et al. 2022

IJERPH

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This study was conducted to determine the degree of depression in family caregivers of spinal-cord-injury patients and to identify factors influencing family caregivers’ depression. The final study subjects were 30 (family caregivers: 6 males and 24 females). The CES-D of family caregivers; general characteristics of spinal-cord-injury patients and family caregivers; and information on physical health, household income, leisure, social activity, family relationship, and life-in-general status of family caregiver were collected. A frequency analysis, normality test, Mann–Whitney test, Kruskal–Wallis test, Spearman Correlation analysis, hierarchical regression analysis, and spider network through a path model analysis were performed. As for the general characteristics, when the patient was economically active, the caregiver’s depression was mean ± SD; 2.04 ± 0.71; otherwise, it was mean ± SD 2.86 ± 0.74, indicating that the caregiver of the non-economic activity patient was more depressed (p = 0.013). In Model 1 of the multiple regression analysis to understand the effect on the depression of the caregiver, it was confirmed that the depression of the caregiver decreased as the family caregiver had more leisure and social activities (B = −0.718, p = 0.001). In Model 2, it was found that the depression of caregivers increased when the patient did not engage in economic activity (B = 0.438, p = 0.016). In the spider-web form through the path model analysis, as the family’s economic level increased, physical health increased by B = 0.755 (p < 0.001), and the increase in physical health (B = 0.424, p = 0.042) was, in turn, a factor in the increase of engagement in leisure and social activities. Various policies will be needed for the successful return to society of spinal-cord-injury patients by ensuring that their leisure and social activities and establishing measures to support their economical income.

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Challenges in traumatic spinal cord injury care in developing countries – a scoping review

Ranjbar Hameghavandi,

Khodadoust,

Hassan Zadeh Tabatabaei

et al. 2024

Front. Public Health

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ObjectiveTo evaluate the leading challenges in developing countries’ traumatic spinal cord injury (TSCI) care.MethodsWe conducted a systematic search in electronic databases of PubMed, SCOPUS, Web of Science, EMBASE, and Cochrane Library on 16 April 2023. Studies that investigated challenges associated with the management of TSCI in developing countries were eligible for review. We extracted related outcomes and categorized them into four distinct parts: injury prevention, pre-hospital care, in-hospital care, and post-hospital care.ResultsWe identified 82 articles that met the eligibility criteria including 13 studies on injury prevention, 25 on pre-hospital care, 32 on in-hospital care, and 61 on post-hospital care. Challenges related to post-hospital problems including the personal, financial, and social consequences of patients’ disabilities and the deficiencies in empowering people with TSCI were foremost studied. Lack of trained human resources, insufficient public education and delays in care delivery were barriers in the acute and chronic management of TSCI. A well-defined pre-hospital network and standard guidelines for the management of acute neurotrauma are needed. Critical challenges in injury prevention include deficiencies in infrastructure and supportive legislation.ConclusionStudies focusing on injury prevention and pre-hospital care in TSCI management in developing countries warrant further investigation. It is imperative to develop systematic and evidence-based initiatives that are specifically tailored to the unique circumstances of each country to address these challenges effectively. By understanding the primary obstacles, policymakers and healthcare providers can establish goals for improving education, planning, legislation, and resource allocation.

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Spinal Cord Injury/Disorder Function, Affiliate Stigma, and Caregiver Burden in Turkey

Cited by 4 publications

References 52 publications

Spinal cord injury: molecular mechanisms and therapeutic interventions

Spinal cord injury: molecular mechanisms and therapeutic interventions

Factor Analysis Affecting Degree of Depression in Family Caregivers of Patients with Spinal Cord Injury: A Cross-Sectional Pilot Study

Challenges in traumatic spinal cord injury care in developing countries – a scoping review

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