Spinal Cord Injury or Dysfunction Quality of Life Rating Scale (SCIDQLRS) (IANR 2022 version)

Huang, Hongyun; Sharma, Hari Shanker; Saberi, Hooshang; Chen, Lin; Sanberg, Paul R.; Xue, Mengzhou; Sharma, Alok; Chen, Di; Siniscalco, Dario; Ramón‐Cueto, Almudena; Hao, Xi Shan; Chen, Lukui; Feng, Shiqing; He, Xijing; Sun, Tiansheng; Li, Jianjun; Guo, Xiaoling; Feng, Yu; Shen, Yixin; Wang, Fangyong; Zheng, Zuncheng; Guo, Xiaodong; Hu, Jianzhong; Zoubi, Ziad M. Al

doi:10.1016/j.jnrt.2022.100016

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…Rats in the AG group were more active than those in the AS group. This finding is in agreement with previously reported results that angiogenesis promotion in injured spinal cords enhances functional recovery in experimental spinal cord injury studies ( Kumar et al, 2018 ; Chen et al, 2022 ; Hong et al, 2022 ; Huang et al, 2022b ). It was suggested that microvascular proliferation would improve motor function recovery, but microvascular inhibition would obstruct motor function recovery.…”

Section: Discussionsupporting

confidence: 94%

Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy

Wang,

Li,

Wang

et al. 2024

Front. Neurosci.

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Background and purposeCervical Spondylotic Myelopathy (CSM), the most common cause of spinal cord dysfunction globally, is a degenerative disease that results in non-violent, gradual, and long-lasting compression of the cervical spinal cord. The objective of this study was to investigate whether microvascular proliferation could positively affect neural function recovery in experimental cervical spondylotic myelopathy (CSM).MethodsA total of 60 male adult Sprague–Dawley (SD) were randomly divided into four groups: Control (CON), Compression (COM), Angiostasis (AS), and Angiogenesis (A G),with 15 rats in each group. Rats in the AS group received SU5416 to inhibit angiogenesis, while rats in the AG group received Deferoxamine (DFO) to promote angiogenesis. Motor and sensory functions were assessed using the Basso Beattie Bresnahan (BBB) scale and somatosensory evoked potential (SEP) examination. Neuropathological degeneration was evaluated by the number of neurons, Nissl bodies (NB), and the de-myelination of white matter detected by Hematoxylin & Eosin(HE), Toluidine Blue (TB), and Luxol Fast Blue (LFB) staining. Immunohistochemical (IHC) staining was used to observe the Neurovascular Unit (NVU).ResultsRats in the CON group exhibited normal locomotor function with full BBB score, normal SEP latency and amplitude. Among the other three groups, the AG group had the highest BBB score and the shortest SEP latency, while the AS group had the lowest BBB score and the most prolonged SEP latency. The SEP amplitude showed an opposite performance to the latency. Compared to the COM and AS groups, the AG group demonstrated significant neuronal restoration in gray matter and axonal remyelination in white matter. DFO promoted microvascular proliferation, especially in gray matter, and improved the survival of neuroglial cells. In contrast, SU-5416 inhibited the viability of neuroglial cells by reducing micro vessels.ConclusionThe microvascular status was closely related to NVU remodeling an-d functional recovery. Therefore, proliferation of micro vessels contributed to function -al recovery in experimental CSM, which may be associated with NVU remodeling.

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Section: Discussionsupporting

confidence: 94%

Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy

Wang,

Li,

Wang

et al. 2024

Front. Neurosci.

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“… 394 , 395 There is another tool, named the SCI or Dysfunction Quality of Life Rating Scale (SCIDQLRS) (IANR 2022 version), which was designed as a single method to assess various items related to quality of life after SCI. 396 It has been reported that 80% of ASIA grade A patients may not recover function and that 54% of ASIA grade B patients and 86% of ASIA grade C-D patients will have varied degrees of neurological recovery. 397 , 398 A combination of assisted physiological tests, such as electrophysiological examination, can better predict the prognosis of SCI patients.…”

Section: Clinical Treatment and Researchmentioning

confidence: 99%

Spinal cord injury: molecular mechanisms and therapeutic interventions

Ren

et al. 2023

Sig Transduct Target Ther

165

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Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. In the past few decades, researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling, but the results have not been ideal. Recently, new pathological mechanisms of SCI, especially the interactions between immune and neural cell responses, have been revealed by single-cell sequencing and spatial transcriptome analysis. With the development of bioactive materials and stem cells, more attention has been focused on forming intermediate neural networks to promote neural regeneration and neural circuit reconstruction than on promoting axonal regeneration in the corticospinal tract. Furthermore, technologies to control physical parameters such as electricity, magnetism and ultrasound have been constantly innovated and applied in neural cell fate regulation. Among these advanced novel strategies and technologies, stem cell therapy, biomaterial transplantation, and electromagnetic stimulation have entered into the stage of clinical trials, and some of them have already been applied in clinical treatment. In this review, we outline the overall epidemiology and pathophysiology of SCI, expound on the latest research progress related to neural regeneration and circuit reconstruction in detail, and propose future directions for SCI repair and clinical applications.

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“…SCI often causes motor and sensory dysfunction [ 23 ]. Due to the poor plasticity of the central nervous system and the limited neuronal regeneration ability, SCI treatment has become a key medical problem globally [ 24 ], and still, there is no effective treatment available in this regard despite its increasing global incidence rate.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the effect and potential mechanism of quercetin in repairing spinal cord injury based on network pharmacology and in vivo experimental verification

Shen,

Liu,

et al. 2023

Heliyon

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Spinal Cord Injury or Dysfunction Quality of Life Rating Scale (SCIDQLRS) (IANR 2022 version)

Cited by 9 publications

References 22 publications

Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy

Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy

Spinal cord injury: molecular mechanisms and therapeutic interventions

Exploration of the effect and potential mechanism of quercetin in repairing spinal cord injury based on network pharmacology and in vivo experimental verification

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