Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis

Foda, Abd Al-Rahman Mohammad; Rafi, Samia; Ikram, Nadeem; Alam, Mariya Syed; Ayesha, Sana

doi:10.1007/s12253-019-00704-2

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Cancers 2024, 16, 1426 2 of 21 New literature is emerging, which suggests that spinal meningiomas may differ from their intracranial counterparts in a number of pertinent ways, including tissue lineage and clonality, molecular characterization and pathways pertinent to meningiomagenesis, risk of recurrence, the utility of surgical grading systems, and adjuvant treatment strategies [2,[4][5][6][7][8][9]. Nonetheless, regardless of location, ongoing challenges in meningioma research include the diagnostic integration of histopathology with molecular markers to accurately predict biological behavior, improvement in post-surgical neurological outcomes, and methods to decrease rates of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Dang,

Mugge,

Awan

et al. 2024

Cancers

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Spinal meningiomas are the most common intradural, extramedullary tumor in adults, yet the least common entity when accounting for all meningiomas spanning the neuraxis. While traditionally considered a benign recapitulation of their intracranial counterpart, a paucity of knowledge exists regarding the differences between meningiomas arising from these two anatomic compartments in terms of histopathologic subtypes, molecular tumor biology, surgical principles, long-term functional outcomes, and recurrence rates. To date, advancements at the bench have largely been made for intracranial meningiomas, including the discovery of novel gene targets, DNA methylation profiles, integrated diagnoses, and alternative systemic therapies, with few exceptions reserved for spinal pathology. Likewise, evolving clinical research offers significant updates to our understanding of guiding surgical principles, intraoperative technology, and perioperative patient management for intracranial meningiomas. Nonetheless, spinal meningiomas are predominantly relegated to studies considering non-specific intradural extramedullary spinal tumors of all histopathologic types. The aim of this review is to comprehensively report updates in both basic science and clinical research regarding intraspinal meningiomas and to provide illustrative case examples thereof, thereby lending a better understanding of this heterogenous class of central nervous system tumors.

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Section: Introductionmentioning

confidence: 99%

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Dang,

Mugge,

Awan

et al. 2024

Cancers

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Clinical, molecular, and genetic features of spinal meningiomas

Deska-Gauthier,

Hachem,

Wang

et al. 2024

Neuro-Oncology Advances

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Spinal meningiomas comprise 25%–46% of all primary spinal tumors. While the majority are benign and slow-growing, when left untreated, they can result in significant neurological decline. Emerging clinical, imaging, and molecular data have begun to reveal spinal meningiomas as distinct tumor subtypes compared to their intracranial counterparts. Moreover, recent studies indicate molecular and genetic subtype heterogeneity of spinal meningiomas both within and across the classically defined WHO grades. In the current review, we focus on recent advances highlighting the epidemiological, pathological, molecular/genetic, and clinical characteristics of spinal meningiomas. Furthermore, we explore patient and tumor-specific factors that predict prognosis and postoperative outcomes. We highlight areas that require further investigation, specifically efforts aimed at linking unique molecular, genetic, and imaging characteristics to distinct clinical presentations to better predict and manage patient outcomes.

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Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis

Cited by 2 publications

References 24 publications

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Clinical, molecular, and genetic features of spinal meningiomas

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