Spindle Cell Carcinoma in the Breast: A Case Report

Abstract

We aim to report on a patient presenting with a rare breast tumor. The tumor was recurrent with the patient having undergone wide local excision twice previously and the diagnosis was inconclusive both times. Under our care, the patient underwent a modified radical mastectomy with a level III dissection and a transverse rectus abdominis myocutaneous (TRAM) flap for reconstruction. The entire procedure was performed in front of a live audience comprising medical students, junior doctors, and consultants, managed with audiovisual feedback enabling a real-time discussion. The final histopathological report showed a spindle-cell tumor of the breast but also mentioned that a Phyllodes tumor could not be ruled out.

A Rare Case of High-Grade Spindle Cell Sarcoma of the Breast: A Case Report

“…Spindle cell sarcomas of the breast are a type of mesenchymal tumors of the breast which are extremely rare, with an incidence of 4.6 cases per million women per year [ 4 ]. These lesions can be arduous to diagnose due to similarity with other breast lesions and mixed histological patterns [ 1 , 2 ]. We present a case of a 15-year-old female with a high-grade spindle cell sarcoma differentiated as PT of the breast upon detailed histological examination, focusing on the difficulties associated with diagnosing and treating these rare complex lesions.…”

“…Differential diagnosis of these lesions includes sarcomatoid/metaplastic carcinoma, primary breast sarcoma, and phyllodes tumor (PT) [ 4 ]. Diagnosing this lesion can be extremely challenging due to similarity with other breast lesions and mixed morphological patterns on histology; however, histological examination of trucut biopsies along with immunohistochemical staining has made it easier to differentiate spindle cell sarcoma from other breast lesions [ 1 , 2 ]. This article presents a rare case of a 15-year-old female with a high-grade spindle cell sarcoma with the aim of enhancing clinical awareness to promote early detection and better management plans for such rare cases.…”

“…Spindle cell sarcomas are rare lesions of the breast which range from benign to highgrade malignant carcinomas, with a prevalence of less than 0.5% per year [1][2][3]. Differential diagnosis of these lesions includes sarcomatoid/metaplastic carcinoma, primary breast sarcoma, and phyllodes tumor (PT) [4].…”

Cardiac Myxoid Spindle Cell Tumor in a Neonate

“…Different subtypes of benign and malignant tumors containing spindle cells have been described. These types of lesions are histologically characterized by a mixture of fibroblast-like spindle cells and sometimes fat cells in the field of myxoid, mucoid, or collagenous materials that can be tracked in different soft tissue organs such as the nervous system, gastrointestinal tract, breast, mesenchymal tissues, and even exocrine and endocrine glands [ 5 ]. Some rare patterns of these lesions have also been revealed in bony structures as well as in retroperitoneal space [ 6 , 7 ].…”