Spindle-Cell Sarcoma Involving the Major Pulmonary Arteries

Teleb, Mohamed; Olivas, Cristina Chacon; Kanu, Obiajulu; Vargas, Luis Fernando Ramos; Ngamdu, Kyari Sumayin; Albaghdadi, Aymen; Mallah, Wael El

doi:10.1080/08998280.2017.11929628

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…It is a type of connective tissue tumor and generally begins in layers of connective tissue such as that under the skin, between muscles, and surrounding organs. Only a handful of cases have been reported around the world from variety of body parts 3 – 9 . As such, SCS constitutes a diagnostic and therapeutic challenge 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Spindle cell sarcoma: a SEER population-based analysis

Feng

Wang

Yibulayin

et al. 2018

Sci Rep

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Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. 3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) database (1973–2017). White people account for 79.1% with median age of 57 years without predominance in any gender. Significant disease specific survival (DSS) and overall survival (OS) were found differentiated in age, T stage, N stage, M stage, AJCC stage, SEER historic stage, tumor locations, surgery, and pathologic grade. In the multivariate Cox analysis, the age >64 years (for DSS, P < 0.001 and for OS, P < 0.001; Reference age ≤64 years), AJCC stage III (for DSS, P = 0.006 and for OS, P = 0.04; Reference: AJCC stage I), and non-surgical treatment (for DSS, P < 0.001 and for OS, P < 0.001; Reference: surgery) were independently associated with worse DSS and OS. In brief, our study demonstrated that SCS mostly found in white people at fifth to seventh decades of life without gender predilection. The patient’s age, AJCC stage, tumor location and surgery were independent prognostic indicators for both DSS and OS of SCS.

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Section: Introductionmentioning

confidence: 99%

Spindle cell sarcoma: a SEER population-based analysis

Feng

Wang

Yibulayin

et al. 2018

Sci Rep

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“…Sarcomas often present with nonspecific symptoms including shortness of breath, cough, lightheadedness, hemoptysis, and chest pain [ 5 ]. In addition, they are often painless, which further contributes to delay in diagnosis [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Spindle Cell Sarcoma With Rare Asymptomatic Cerebellar Metastasis

Miyaki,

Wu,

Nye

et al. 2024

Cureus

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Sarcomas are one of the rarest cancers, occurring in less than 1% of all adult malignancies. Spindle cell sarcomas are one subset of soft tissue sarcomas that are even less commonly reported in the literature due to the scarcity of cases, especially with the presence of brain metastases. We present a case of an adult male who presented with non-specific exertional dyspnea and chest pain, which was found to have spindle cell sarcoma with cerebellar metastasis.

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“…breast [8], major pulmonary arteries [9], maxilla [10], frontal sinus [11], parotid gland [12], prostate [13], thyroid [14], oesophagus [15], larynx [16], liver [17], and heart [18], have been described. Their rates of survival and prognostic factors are supposed to be different by site.…”

Section: Introductionmentioning

confidence: 99%

A nomogram to predict the individual outcomes of spindle cell sarcoma originated in limbs

Sun

Hong

et al. 2022

Preprint

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Background Spindle cell sarcoma is a relatively rare type of sarcoma that mostly originates in soft tissues, but it tends to grow rapidly, and its clinical treatment is a major challenge. From previous reports in the literature, this type of sarcoma has a high proportion of cases affecting the limbs, and research on this topic has potential clinical value. The present study developed a nomogram to effectively predict the survival of patients and analyse the independent prognostic factors of primary limb spindle cell sarcoma.Methods The clinical information of 748 primary limb spindle cell sarcoma patients was obtained from the SEER database. After applying the inclusion/exclusion criteria, 542 patients were included in our study, and they were divided into a training group and a validation group at a ratio of 2:1. The X-tile program was used to determine the best cut-off point for age and tumour size. Univariate and multivariate analyses were used to determine independent prognostic factors, and the training group data were used to construct a nomogram to predict patients’ overall survival and cancer-specific survival. The training cohort data were used for internal verification of the nomogram, and the validation cohort data were used for external verification of the nomogram. The C index was used to calculate the predictive performance of the nomogram. Additionally, we built an online forecasting website.Results The primary limb spindle cell sarcoma has high proportion of all spindle cell sarcoma, and it may have potential associations with pathologic fractures, then marital status, age, historic stage, tumour size and surgical type were identified as five independent prognostic factors, and combined with these factors, a nomogram was constructed for predicting 5-year and 10-year overall survival rates and cancer-specific survival rates. The overall survival rate and tumour-specific survival rate prediction internal validation consistency index (C index) was 0.824 (95% CI 0.794-0.854) and 0.854 (95% CI 0.825-0.883), while the externally validated C index was 0.765 (95% CI 0.706-0.824) and 0.766 (95% CI 0.700-0.832), respectively. Additionally, in order to make the nomogram more convenient and accurate, an online website was created where after entering basic clinical information. The website can help clinicians provide guidance to patients who have these rare sarcomas.Conclusions The nomogram constructed for primary limb spindle cell sarcoma can predict the survival of these patients.

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Spindle-Cell Sarcoma Involving the Major Pulmonary Arteries

Cited by 3 publications

References 14 publications

Spindle cell sarcoma: a SEER population-based analysis

Spindle cell sarcoma: a SEER population-based analysis

A Rare Case of Spindle Cell Sarcoma With Rare Asymptomatic Cerebellar Metastasis

A nomogram to predict the individual outcomes of spindle cell sarcoma originated in limbs

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