Spindle Cell Variants of Embryonal Rhabdomyosarcoma in the Paratesticular Region

Leuschner, Ivo; Newton, William A.; Schmidt, Dietmar; Sachs, Nancy; Asmar, Lina; Hamoudi, Ala B.; Harms, D.; Maurer, Harold M.

doi:10.1097/00000478-199303000-00002

Cited by 163 publications

(124 citation statements)

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“…6). Additional retrospective analyses were then performed by IRS pathologists, who reconfirmed the uniqueness of these tumors (39). They thus were included as a separate category in the International Classification (9).…”

Section: Newer Entitiesmentioning

confidence: 99%

Pathologic Classification of Rhabdomyosarcomas and Correlations with Molecular Studies

2001

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Rhabdomyosarcoma, the most common soft-tissue malignancy of childhood and adolescence, comprises a group of differing pathobiologic entities linked by their common propensity for formation of neoplastic skeletal muscle, a feature that results from biological forces related to aberrant transcription signals and the resultant production of myogenic proteins. At a molecular level, however, rhabdomyosarcomas form a heterogeneous group that can be subdivided into distinct clinicopathologic entities based on morphologic appearance and genetic makeup. These differing morphologic features were recognized in the mid-1900s by Horn and Enterline with their division of rhabdomyosarcomas into embryonal, alveolar, botryoid, and pleomorphic subtypes. More recent histologic and biologic studies have resulted in description of additional entities, such as spindle cell and anaplastic rhabdomyosarcoma, and refinements in recognition of the original entities, such as solid-alveolar rhabdomyosarcoma. Familiarity with newer classifications and their relationship to molecular aberrations is key to stratifying patients on current therapeutic protocols and proposed innovative genetic therapies.

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Section: Newer Entitiesmentioning

confidence: 99%

Pathologic Classification of Rhabdomyosarcomas and Correlations with Molecular Studies

2001

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“…These tumors have characteristic morphologic features and immunostaining profiles (40,41). The overall morphologic features and the absence of specific antigen expression in the cases we report exclude these diagnoses.…”

Section: Discussionmentioning

confidence: 48%

Malignant Fibrous Histiocytoma of the Spermatic Cord: Report of Two Cases and Review of the Literature

2002

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“…The spindle cell variant of rhabdomyosarcoma was first recognized in the early 1990 s and was thought to occur principally in children and adolescents in the paratesticular region. 43,44 Such lesions in young patients have been shown to have an extremely good prognosis with a 5-year survival of greater than 90%. Similar lesions in adults were first described in 1998, 45 and subsequent experience has shown that, in older patients, these lesions occur mainly in the third and fourth decades and show a striking predilection for the head and neck region, at which site it is difficult to obtain wide surgical margins.…”

Section: Spindle Cell/sclerosing Rhabdomyosarcomamentioning

confidence: 99%

Recently characterized soft tissue tumors that bring biologic insight

Fletcher

2014

Modern Pathology

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Previously unrecognized but clinicopathologically (and often molecularly) distinct types of soft tissue tumor continue to be characterized, allowing wider recognition, more consistent application of diagnostic criteria, more reliable prediction of tumor behavior and enhancement of existing classification schemes. Examples of such 'entities' that have become much better understood over the past decade or so include deep 'benign' fibrous histiocytoma, hemosiderotic fibrolipomatous tumor, PEComa, spindle cell liposarcoma, myoepithelial tumors of soft tissue and spindle cell/sclerosing rhabdomyosarcoma. These tumor types, as well as the insights which they have engendered, are briefly reviewed here.

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Spindle Cell Variants of Embryonal Rhabdomyosarcoma in the Paratesticular Region

Cited by 163 publications

References 0 publications

Pathologic Classification of Rhabdomyosarcomas and Correlations with Molecular Studies

Pathologic Classification of Rhabdomyosarcomas and Correlations with Molecular Studies

Malignant Fibrous Histiocytoma of the Spermatic Cord: Report of Two Cases and Review of the Literature

Recently characterized soft tissue tumors that bring biologic insight

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