Spindle transfer for the treatment of infertility problems associated to poor egg quality: a pilot trial

Kostaras, Konstantino; Costa-Borges, Nuno; Psathas, Panagiotis; Calderón, Gloria; Nikitos, Eros

doi:10.1186/isrctn11455145

Cited by 4 publications

(4 citation statements)

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“…This is the antithesis of how scientific progress should be promoted and, thus, it was seriously criticized [ 26 , 60 ]. Recently, private fertility clinics have taken advantage of this status of legal void of MRTs in Europe, and two clinical trials have begun, one in Ukraine (led by Dr Zhang, [ 62 ]) and another one in Greece [ 63 ]. Both trials have reported child births during 2019 and more are expected in the near future.…”

Section: Resultsmentioning

confidence: 99%

“…Both trials have reported child births during 2019 and more are expected in the near future. The lack of a therapeutic aim is the most alarming point, since these two trials are being employed to improve the fertility in elderly women with failure in several in vitro fertilization cycles [ 62 , 63 ]. However, there is not enough scientific evidence supporting the role of mitochondrion in infertility [ 23 ] of uncertain etiology.…”

Section: Resultsmentioning

confidence: 99%

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Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

Sendra

García-Mares

Herrero

et al. 2021

IJMS

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Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring with a genetic link is important for the affected families, and mitochondrial replacement techniques (MRTs) allow them to do so. MRTs consist of transferring the nuclear DNA from an oocyte with pathogenic mtDNA to an enucleated donor oocyte without pathogenic mtDNA. This paper aims to determine the efficacy, associated risks, and main ethical and legal issues related to MRTs. Methods: A bibliographic review was performed on the MEDLINE and Web of Science databases, along with searches for related clinical trials and news. Results: A total of 48 publications were included for review. Five MRT procedures were identified and their efficacy was compared. Three main risks associated with MRTs were discussed, and the ethical views and legal position of MRTs were reviewed. Conclusions: MRTs are an effective approach to minimizing the risk of transmitting mtDNA diseases, but they do not remove it entirely. Global legal regulation of MRTs is required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

Sendra

García-Mares

Herrero

et al. 2021

IJMS

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“…. ., named spindle transfer, that allows the replacement of the entire cytoplasm of poor quality eggs" (57). Information from this "pilot trial," as they have called it, comes from three sources: one conference paper, an International Standard Randomised Controlled Trial Number (ISRCTN) registry, and media reports (25,57,65).…”

Section: Medical Travel For Mitochondrial Replacement: Mexico Ukraine Greece and Spainmentioning

confidence: 99%

“…., named spindle transfer, that allows the replacement of the entire cytoplasm of poor quality eggs" (57). Information from this "pilot trial," as they have called it, comes from three sources: one conference paper, an International Standard Randomised Controlled Trial Number (ISRCTN) registry, and media reports (25,57,65). From these sources, we know that the trial has three inclusion criteria: Women must be under age 40, must have been diagnosed with infertility problems due to poor oocyte quality, and must have had at least two previous failed in vitro fertilization attempts.…”

Section: Medical Travel For Mitochondrial Replacement: Mexico Ukraine Greece and Spainmentioning

confidence: 99%

The Regulation of Mitochondrial Replacement Techniques Around the World

Cohen¹,

Adashi

Gerke³

et al. 2020

Annu. Rev. Genom. Hum. Genet.

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Mitochondrial replacement techniques (MRTs, also referred to as mitochondrial replacement therapies) have given hope to many women who wish to have genetically related children but have mitochondrial DNA mutations in their eggs. MRTs have also spurred deep ethical disagreemensts and led to different regulatory approaches worldwide. In this review, we discuss the current regulation of MRTs across several countries. After discussing the basics of the science, we describe the current law and policy directions in seven countries: the United Kingdom, the United States, Canada, Australia, Germany, Israel, and Singapore. We also discuss the emerging phenomenon of medical tourism (also called medical travel) for MRTs to places like Greece, Spain, Mexico, and Ukraine. We then pull out some key findings regarding similarities and differences in regulatory approaches around the world. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 21 is August 31, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Enucleated oocyte donation: first for infertility treatment, then for mitochondrial diseases

Pennings

2022

J Assist Reprod Genet

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Spindle transfer for the treatment of infertility problems associated to poor egg quality: a pilot trial

Cited by 4 publications

References 0 publications

Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

The Regulation of Mitochondrial Replacement Techniques Around the World

Enucleated oocyte donation: first for infertility treatment, then for mitochondrial diseases

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