Spine and Spinal Cord Trauma

Zhang, Shihao; Wadhwa, Rishi; Haydel, Justin; Toms, Jamie; Johnson, Kemmian D.; Guthikonda, Bharat

doi:10.1016/j.ncl.2012.09.012

Cited by 39 publications

(12 citation statements)

References 30 publications

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“…Thoracolumbar spinal cord injuries are manifested primarily by paralysis of the lower limbs, bowel and bladder dysfunction, and sympathetic nervous system disorder [2,3]. Neuroprotective treatment can be performed in acute phases with ganglioside (GM-1), mouse nerve growth factor (NGF), etc.…”

Section: Introductionmentioning

confidence: 99%

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

et al. 2014

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BackgroundUmbilical cord mesenchymal stem cells (UCMSCs) have a considerable advantage and potential in treating for central nervous system diseases and have become a novel alternative treatment for spinal cord injury. This study aims to compare the neurological function outcome of stem cell transplantation, rehabilitation therapy, and self-healing for sequelae of spinal cord injury.MethodsThirty-four cases of thoracolumbar spinal cord injury were randomly divided into three groups: the stem cell transplantation group was given CT-guided UCMSC transplantation twice; the rehabilitation group received rehabilitation therapy; and the blank control group did not receive any specific treatment. AIS grading, ASIA scoring, the manual muscle strength and muscle tension scale, and the Barthel index were used to evaluate the clinical outcome. Urodynamic examination was also performed for patients in the UCMSC group and the rehabilitation therapy group.ResultsSeven of the ten patients in the UCMSC group had significant and stable improvement in movement, self-care ability, and muscular tension; five of the forteen patients (36%) in the rehabilitation group also had certain improvement in these aspects. Urodynamic examination demonstrated that patients in the UCMSC group exhibited an increase in maximum urinary flow rate and maximum bladder capacity, as well as a decrease in residue urine volume and maximum detrusor pressure. The rehabilitation group exhibited decreased maximum bladder capacity, but no perceptible change in maximum urinary flow rate, residue urine volume or maximum detrusor pressure.ConclusionsUCMSC transplantation can effectively improve neurological functional recovery after spinal cord injury, and its efficacy is superior to that of rehabilitation therapy and self-healing.Trial registrationThe present clinical study was registered at chictr.org (registration number: NCT01393977).

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Section: Introductionmentioning

confidence: 99%

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

et al. 2014

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“…Musculoskeletal disorders include fractures, acute soft tissue injuries (i.e., bruises, sprains, or strains); non-articular and non-rheumatic soft tissue disorders, tissue disorders including local myofascial pain syndrome and systemic fibromyalgia, arthritis, neurological disorders, amputations, and problems of postoperative rehabilitation following interventional orthopedic procedures [ 20 ]. Functional disorders that were evaluated in this review included traumatic injuries of the spine and injuries of the spinal cord, nerve roots, bone structure, and disk ligaments of the spine [ 21 ]. Postural changes considered included scoliosis, kyphosis, and lordosis.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Risk Factors of Musculoskeletal Disorders in Basketball Players: Systematic Review and Meta-Analysis

et al. 2023

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Musculoskeletal disorders characteristically induce pain and limitations in mobility, ability, and overall functioning. In athletes, including basketball players, disorders such as back pain, postural changes, and spinal injuries are common. This systematic review aimed to evaluate the prevalence of back pain and musculoskeletal disorders in basketball players and ascertain the associated factors. Methods: The Embase, PubMed, and Scopus databases were searched for studies published in English without a time limit. Using STATA, meta-analyses were performed to estimate the prevalence of pain and musculoskeletal disorders of the back and spine. Results: Of the 4135 articles identified, 33 studies were included in this review, with 27 studies included in the meta-analysis. Of these, 21 were used for the meta-analysis of back pain, 6 articles were used for the meta-analysis of spinal injury, and 2 studies were used for the meta-analysis of postural changes. The overall prevalence of back pain was 43% [95% CI, −1% to 88%]; of these, the prevalence of neck pain was 36% [95% CI, 22–50%], the prevalence of back pain was 16% [95% CI, 4–28%], the prevalence of low back pain was 26% [95% CI, 16–37%], the prevalence of thoracic spine pain was 6% [95% CI, 3–9%]. The combined prevalence of spinal injury and spondylolysis was 10% [95% CI, 4–15%], with a prevalence of spondylolysis of 14% [95% CI, 0.1–27%]. The combined prevalence of hyperkyphosis and hyperlordosis was 30% [95% CI, 9–51%]. In conclusion, we found a high prevalence of neck pain, followed by low back pain and back pain, in basketball players. Thus, prevention programs are important to improve health and sports performance.

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“…Open Journal of Therapy and Rehabilitation nomically, resulting in a significant loss of workforce [1]. While damage to the spine primarily affects the bone structure and connective tissue, it also leads to a mechanical imbalance, pain and impaired mobility, whereas damage to the spinal cord usually results in partial or complete paralysis as the neurological structures are damaged [2] [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Patients Who Received Robotic Therapy after Spinal Cord Injuries

Baloğlu¹

2020

OJTR

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Background: This study aims to evaluate the effectiveness of the robotic device used in lower limb rehabilitation to reduce motor impairment and improve motor performance in patients with traumatic spinal injury. Methods: The data were obtained by retrospective analysis of patients who underwent lower extremity rehabilitation after traumatic spinal injury by robot-assisted rehabilitation in the hospital between December 2017 and December 2019. The results were statistically analyzed and shown as mean ± SD (min-max). Results: A total of 51 patients with mean age of 59.51 ± 8.2 (38-72) were admitted to the clinic. Mean ages of thirty-one male patients and twenty females patients were 58.74 ± 8.88 (38-77) and 60.7 ± 7.09 (44-72), respectively. Comparing ages in terms of gender, it was not statistically significant (p = 0.441). Body mass indexes of male patients were 32.84 ± 6.52 (20-48) and 31.4 ± 7.73 (18-48) for females. Body mass index of patients was not statistically significant in terms of their gender (p = 0.478). Oswestry disability index scores were 32.04 ± 10.74 (16-58) before treatment and 30.69 ± 10.31 (15-55) after treatment. Oswestry disability index values before and after robotic rehabilitation were statistically significant (p < 0.001). Significant improvement was observed in ASIA scale values after rehabilitation. Conclusions: The motor function gains obtained during the robot-assisted treatment of traumatic spinal injury patients showed robotic device was useful in the training program. Robotic rehabilitation was effective in the improvement of the lower extremities during motor examination.

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Spine and Spinal Cord Trauma

Cited by 39 publications

References 30 publications

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

Prevalence and Risk Factors of Musculoskeletal Disorders in Basketball Players: Systematic Review and Meta-Analysis

Evaluation of Patients Who Received Robotic Therapy after Spinal Cord Injuries

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