Spiradiclis quanzhouensis, a new species of Rubiaceae from northeastern Guangxi, China is described and illustrated. It is similar to S. umbelliformis, but can be distinguished by its rosulate habit, subglabrous stems, leaf blades that are pubescent on both surfaces, lanceolate purple‐pubescent stipules that are undivided or sometimes bifid in apical 1/3, an inflorescence with 2–4 flowers, lanceolate 4–5 mm long calyx lobes that are purple‐pubescent outside, a salveriform corolla that is light purple‐pubescent outside, a semi‐inferior ovary, and capsules that are light purple‐pubescent with persistent calyx lobes 5–6 mm, in fruit 2 × as long as capsule.