Spiradiclis yanii Y.Nong & L.Wu (Rubiaceae), a new species from Guangxi, China, is described and illustrated. This new species is most similar to S. tomentosa, but it can be easily distinguished by being densely multicellular villous, leaves narrow elliptic or oblanceolate, apex acute or shortly acuminate, stipules 2–4, linear or linear lanceolate, 4–8 mm, densely villous, corolla tube 3 mm, sparsely pubescent inside, flower homomorphism, lobes 3–5, stamens arising at the base of the tube, stigma 2-lobed, lobes ovoid, slightly swollen, 0.2 mm. The habitat of Spiradiclis yanii is extremely fragile. Therefore, this species deserves close attention and protection.