Spiramycin does not potentiate quinine treatment of falciparum malaria in pregnancy

A Comparative Study of Quinine and Artemether in the Treatment of Severe Malaria in Nigerian Children

“…Although ACPR was 100 % at day 14 in both groups, none of them completely eliminate the parasites. This study supports findings that both artemether and quinine lack the ability to prevent malaria re-infection [12,13].…”

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

“…This was thought to be caused by irreversible inhibition of liver function-dependent CYP3A4-mediated metabolism and a displacement of quinine from plasma proteins. No escalated side effects or parasite clearance time was observed when spiramycin was combined with quinine [226]. A study of 24 patients concluded there is no PK interaction between AZM and chloroquine [154].…”

A Trial of Artemether or Quinine in Children with Cerebral Malaria

“…A disadvantage of both artemether and quinine is that they are relatively inefficient at eradicating infection. 15,16 In the first year of the study it became apparent that a large number of children who were apparently free of parasitemia at discharge had parasites in their blood at the one-month follow-up (30 percent of the artemether group and 18 percent of the quinine group). In the second and third years of the study, all children were given pyrimethaminesulfadoxine at the end of the treatment period.…”