Splanchnic Vein Thrombosis in Acute Pancreatitis

Harris, Samar; Naina, Harris V.; Vege, Santhi Swaroop

doi:10.14309/00000434-200809001-00209

Cited by 2 publications

(12 citation statements)

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“…After critical review, 18 observational (15 retrospective and 3 prospective) studies published between 2008 and 2020 met the inclusion criteria. 1,3,4,8,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Seven of these studies were published only in abstract form. [21][22][23][24][25]31,32 The studies originated from North America (n = 9), Europe (n = 6), and Asia (n = 3) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…1,3,4,8,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Seven of these studies were published only in abstract form. [21][22][23][24][25]31,32 The studies originated from North America (n = 9), Europe (n = 6), and Asia (n = 3) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies specified the protocol for anticoagulation (Table 1) 3,21,22,24,25,28,[30][31][32] and indications included triple vessel involvement, 8 SVT in the absence of varices or collaterals, 4,31 presence of pulmonary emboli, 4,8,31 presence of deep vein thrombosis, 3,4,31 stroke during admission, 3 and presence of complications as a result of SVT. 8 Inter-study and intra-study variability was observed in relation to the therapeutic anticoagulation regimens and duration of treatment (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Studies reporting on the same patient population were excluded, however, in some instances we were unable to discern whether the same group of authors utilized the same patient data across two different studies, and therefore, the studies were included. 4,23,25,32 It was not possible to reach a conclusion as to the anticoagulant of choice or the duration of treatment due to the variability observed in these variables, between, and within studies. Seven studies were published in abstract form only and it was not possible to get the complete data set from these.…”

Section: Discussionmentioning

confidence: 99%

“…Seven studies were published in abstract form only and it was not possible to get the complete data set from these. [21][22][23][24][25]31,32 Not all studies stratified the severity of pancreatitis, thereby preventing a comparison between the severity of pancreatitis and the incidence of SVT. We were limited in our ability to compare the risk of hemorrhagic complications and mortality in the studies reporting recanalization rates due to the variability in reporting these outcomes among them.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta‐analysis

Anis

Adiamah

Lobo

et al. 2021

J of Gastro and Hepatol

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Background and Aim:This meta-analysis aimed to estimate the incidence of splanchnic vein thrombosis (SVT) in patients with acute pancreatitis and assess the effects of therapeutic anticoagulation. Methods: Systematic searches of the Medline, Embase, and Cochrane databases were undertaken to identify studies reporting the incidence and outcomes associated with SVT in patients with acute pancreatitis. The pooled incidence, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model. PROSPERO database registration no. CRD 42021230912. Results: Only 18 of the 238 studies identified met the inclusion criteria. Of the 943 patients who had SVT, 264 (28.0%) received anticoagulation. The pooled incidence of SVT at first presentation of acute pancreatitis was 15% (95% CI 5 to 26%), but was 17% (95% CI 14 to 20%) in all studies. Recanalization was more likely to occur in the anticoagulation-treated than in the untreated group (OR 0.51, 95% CI 0.31 to 0.83, P = 0.007). There were no differences in hemorrhagic complications (OR 2.27, 95% CI 0.81 to 6.37, P = 0.12) or overall mortality (OR 2.37, 95% CI 0.86 to 6.52, P = 0.10) in relation to the use of anticoagulation. The overall incidence of portal hypertension in patients was 60% (95% CI 55 to 65%). However, it was not possible to determine the incidence in each group. Conclusions: The incidence of SVT in patients with acute pancreatitis is significant. Treatment with anticoagulants improved the odds of recanalization but did not increase the risk of hemorrhagic complications or overall mortality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta‐analysis

Anis

Adiamah

Lobo

et al. 2021

J of Gastro and Hepatol

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Relationship of Arterial Changes in Acute Pancreatitis on CT Angiography with Modified CT Severity Index

Vermani

Kaushal

Kaur

et al. 2021

Journal of Gastrointestinal and Abdominal Radiology

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Purpose To evaluate the prevalence of arterial changes in patients with acute pancreatitis (AP) on computed tomography angiography (CTA) and determine their association with etiology of AP, presence of necrosis, collections and severity of AP. Materials and Methods A total of 50 patients (20 women, 30 men; mean age: 43.04 ± 13.98; age range: 18–77 years) with AP underwent contrast-enhanced computed tomography (CECT) scan and CTA of abdomen, which was evaluated for necrosis and fluid collection (s). On CTA, splanchnic arterial structures were assessed for vascular complications. Association between vascular changes and presence of necrosis, fluid collections, etiology of AP and severity of AP (as assessed by modified computed tomography severity index CTSI) was determined. Results Arterial complications were seen in 28 percent (14/50). The most frequently involved artery was superior pancreaticoduodenal artery (12 percent), followed by splenic artery (8 percent) and right gastric artery (8 percent; Fig. 1). No significant association was seen between arterial changes and gallstone or alcohol-induced AP. Arterial changes showed a significant association with presence of acute necrotizing pancreatitis (ANP), presence of collections and severe AP (CTSI 8–10) (p < 0.05 for each). Conclusion Arterial changes on CTA are frequently seen in patients of AP having ANP. There is a significant association between arterial changes and presence of necrosis, collections and severe AP.

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Splanchnic Vein Thrombosis in Acute Pancreatitis

Cited by 2 publications

References 0 publications

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta‐analysis

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta‐analysis

Relationship of Arterial Changes in Acute Pancreatitis on CT Angiography with Modified CT Severity Index

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