Splenic Abscess: An Unusual Presentation of COVID-19?

Al-Ozaibi, Labib; AlShaikh, Mohammed; Makhdoom, Maahroo; Alzoabi, Osama M.; Busharar, Hajar A.; Keloth, Tasnim

doi:10.1159/000509644

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…12 Al Ozaibi et.al 2020 in one of his research said that corona virus directly infect and damages the spleen leading to splenic abscess and also causes damage to other lymphoid tissues. 13 The cytokines are produced in response to infection by covid 19, there is excessive production of cytokines having antiviral action, the lymphocytes produces lymphokines. Jun-Ming Zhang, et.al 2007 in one of his research said that Cytokines may act on the cells that secrete them and have autocrine action.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytopenia delays recovery in COVID-19 infected patients.

Chaudhry

Rashid²,

Rasheed

et al. 2022

TPMJ

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Objective: To observe the effect of reduced lymphocyte count on the recovery of Covid 19 infected patients. Study Design: Observational study. Setting: Rawal Institute of Health Sciences Islamabad, Pakistan Institute of Medical Sciences, Islamabad. Period: March 2021 till June 2021. Material & Methods: Sample Size: One hundred adult humans suffering from COVID-19 infection. Hundred adult patients with positive PCR test for corona virus were selected. Adult patients belonging to both genders with reduced lymphocyte count and no immunological and blood disorder were included and those below the age of 18 years with any disorder related to immune system or blood were excluded. Adult patients were divided in two groups A and B with 50 patients in each group. Lymphocyte count of all the patients was noted from the record in the laboratory of Rawal institute of health sciences and Pakistan institute of Medical sciences Islamabad. Group A were those whose lymphocyte count was close to reference range and group B were those whose lymphocyte count was very low. Follow up of all the patients was done. Reduction and disappearance of symptoms like fever and cough were considered as recovery symptoms. Statistical Analysis: Data was entered using SPSS version 25. Data was checked for normality by using shapirowilk test. The comparison in the days of recovery with the lymphocyte count showed a significant difference of P value of 0.00. Results: Group A patients had mean lymphocyte count 0.87 x 109 / L and Group B had mean lymphocyte count of 0.45 x 109 / L. The average recovery time for corona virus infected patients with marked reduction in lymphocyte count is 19 days and those with mild reduction in lymphocyte count the average recovery time is 12 days. Conclusion: Patients suffering from COVID-19 infection with less lymphocytopenia showed early recovery and disappearance of symptoms as compared to those with more lymphocytopenia.

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Section: Discussionmentioning

confidence: 99%

Lymphocytopenia delays recovery in COVID-19 infected patients.

Chaudhry

Rashid²,

Rasheed

et al. 2022

TPMJ

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“…The optimal management strategy for splenic abscess remains controversial; to date, the traditional surgical approach involving splenectomy has been the treatment of choice, as reported in the first case of splenic abscess in a patient with SARS-CoV-2 infection. 20 Presently, specific centers consider antibiotics alone as a sufficient treatment option, which is supported by case series with success rates of 75%. 6 Fluid culture and sensitivity analysis of the drained abscess must be performed, being aware that COVID-19 positivity may be associated with unusual causative organisms.…”

Section: Discussionmentioning

confidence: 99%

Splenic abscess as a possible sequela of COVID-19: a case series

et al. 2021

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Splenic abscess is an aggressive disease with a non-specific etiology and symptoms that are systemically detrimental. During the current COVID-19 pandemic, there has been a noted rise in the incidence of splenic abscesses. The aim of this article was to explore whether infection with the SARS-CoV-2 virus increases the risk of developing splenic abscesses. We reviewed three cases with SARS-CoV-2 infection who developed splenic abscess. The clinical characteristics, treatment course, management and outcome are reported. We perceived that hypercoagulability status, superimposing infections and immunosuppression were related to SARS-CoV-2 infection. These were common factors in these three observed cases of splenic abscess as a complication related to the new viral pandemic. SARS-CoV-2 infection might be a risk factor in development of splenic abscess. SIMILAR CASES PUBLISHED: To the best of our knowledge only one case similar to our case series was published.

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“…Significant SARS-CoV-2-induced changes were observed when examining spleen samples. A case analysis of a 55-year-old patient with COVID-19 revealed that along with the loss of follicles in the white pulp of the spleen, there was lymphoid hyperplasia and a mosaic structure of the white pulp, i.e., some lymphoid follicles had a normal intact structure, while most of them lacked germinal centers, and in some cases, there was an enlarged mantle zone but no clear marginal zone [ 69 ]. At dissection, postmortem spleens of COVID-19 patients were generally contracted with shrunk capsules and were characterized by blood clots, anemic infarction, and hemorrhages [ 70 ].…”

Section: Structural Impairment Of Lymphoid Tissue In Covid-19mentioning

confidence: 99%

Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive Overview

Kudryavtsev

Rubinstein

Головкин

et al. 2022

Viruses

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in humans more than two years ago and caused an unprecedented socio-economic burden on all countries around the world. Since then, numerous studies have attempted to identify various mechanisms involved in the alterations of innate and adaptive immunity in COVID-19 patients, with the ultimate goal of finding ways to correct pathological changes and improve disease outcomes. State-of-the-art research methods made it possible to establish precise molecular mechanisms which the new virus uses to trigger multisystem inflammatory syndrome and evade host antiviral immune responses. In this review, we present a comprehensive analysis of published data that provide insight into pathological changes in T and B cell subsets and their phenotypes, accompanying the acute phase of the SARS-CoV-2 infection. This knowledge might help reveal new biomarkers that can be utilized to recognize case severity early as well as to provide additional objective information on the effective formation of SARS-CoV-2-specific immunity and predict long-term complications of COVID-19, including a large variety of symptoms termed the ‘post-COVID-19 syndrome’.

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Splenic Abscess: An Unusual Presentation of COVID-19?

Cited by 10 publications

References 13 publications

Lymphocytopenia delays recovery in COVID-19 infected patients.

Lymphocytopenia delays recovery in COVID-19 infected patients.

Splenic abscess as a possible sequela of COVID-19: a case series

Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive Overview

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