Splenic Angiosarcoma Diagnosed on Bone Marrow Biopsy: Case Report and Literature Review

Abstract

Primary splenic angiosarcoma carries a poor prognosis and is among the rarest forms of malignancy. An overwhelming majority of patients with splenic angiosarcoma will develop metastases. However, osseous metastatic disease is rare. We present an 83 year old hispanic female who was diagnosed with primary splenic angiosarcoma on bone marrow biopsy performed for a hematologic workup. We highlight key historical, laboratory, imaging, and pathological features of splenic angiosarcoma. The synthesis of both imaging features and clinical history is essential for establishing early diagnosis in these patients.

Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review

“…In a subset of cases, splenic rupture occurs as an initial presentation, usually signifying a poor prognosis (9,(11)(12)(13). Throughout the course of the disease, metastases are common, often occurring early and extensively (14). The liver, lungs, lymph nodes, bone marrow and bone are frequent sites of metastasis (4,10).…”

Splenic Angiosarcoma with Bone Marrow Involvement Initially Diagnosed as Systemic Mastocytosis: A Case Report

“…Primary splenic angiosarcoma is a rare, highly aggressive vascular malignancy comprising about 2.6% of angiosarcomas, with an incidence of approximately 0.14-0.25 cases per million individuals [1,5]. It is often metastatic to the liver, lungs, lymph nodes, and bone and has a poor prognosis [1][2][3][4].…”

“…It is often metastatic to the liver, lungs, lymph nodes, and bone and has a poor prognosis [1][2][3][4]. Bone marrow metastasis from primary splenic angiosarcoma is very rare, with only a few reports in the literature [5]. The lesion is composed of abnormal, malignant endothelial cells, with variable histology between cases.…”