Splenic Volume: Correlation between Ultrasonogram and Standard CT Measurements

Paul, Fonindra Nath; Taher, Md. Abu; Jahan, Mahood uz; Roy, Shyamal K.; Sarkar, Saumya; Sultana, Sayeeda

doi:10.3329/bmrcb.v43i2.35182

Cited by 4 publications

(8 citation statements)

References 6 publications

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“…The mean of spleen thickness in the current study was 3.93 ± 1.054 cm which is consistent with the study conducted in Ethiopia (33). But less than from studies conducted in Russia, Bangladesh, Jordan, Nepal, north India, and Nigeria (8,41,42,44,60,63,64) and is greater than from a study conducted in Sudan (29).…”

Section: Discussionsupporting

confidence: 88%

“…The mean of spleen width was 4.79 ± 0.998 cm which is less than from study conducted in Bangladesh, Nepal, Kashmir, North India and Nigeria (8,42,44,61,63,64) and greater than from study conducted in Sudan and Northern Ethiopia (29,33).…”

Section: Discussionmentioning

confidence: 56%

“…The mean of spleen length at 95% CI with SD was 10.24 ± 1.45 cm which is consistent with studies conducted in Russia and Kashmir (60,61). But, less than from study conducted in Turkey( 42), Bangladesh, Jordan and North India (8,41,62,63) and greater than from study conducted in Nepal, Nigeria, Sudan and Northern Ethiopia (29,33,42,64).…”

Section: Discussionmentioning

confidence: 90%

“…In diseases condition spleen enlarges at different rates in its dimensions and most easily vulnerable organs (8)(9)(10). A variety of diseases condition alters spleen dimensions, where splenomegaly and its consequence becomes a primary clinical concern in any part of the world (11,12).…”

Section: Introductionmentioning

confidence: 99%

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Morphometric Assessment of Spleen Dimensions and Its Correlates Among Individual Living in Arba Minch Town, Southern Ethiopia

Demissie

Prasad

Fikadu

et al. 2021

Preprint

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Introduction: The spleen is a vital lymphoid soft organ that demands constant attention from the clinical point of view. It is multi-dimensional organs that enlarge in all dimensions in disease conditions. The detection of the spleen by palpation on physical examination is not an approval of an enlarged spleen because an unenlarged spleen may palpable. Therefore, this study aimed to assess the Morphometry of spleen dimensions and its correlates among individuals living in Arba Minch Town by sonographic examinations.Methods and Materials: Community-based cross-sectional study was conducted in Arba Minch town from February 1 to March 30, 2020. A multi-stage systematic and simple random sampling technique was applied to select study participants. Data was entered into Epi-Data version 3.1software and exported to SPSS version 20 software for analysis.Result: A total of 708 individuals, 390 (55.1%) males and 318 (44.9 %) females were included in the current study. The mean splenic length, width, thickness and volume were 10.24 cm, 4.79 cm, 3.93 cm, and 109.34 cm³, respectively. The mean spleen length, width, thickness and volumes among males were 10.64 cm, 4.92 cm, 4.05 cm and 119.81 cm³ and among females were 9.75 cm, 4.63 cm, 3.78 cm and 96.50 cm³ respectively. Significant negative correlations were found between age and spleen dimensions. Significant positive correlations were observed between spleen dimensions and height, weight, Body Mass Index, and Body Surface area. But, the correlation between width and body mass index was non-significant (p-value > 0.05).Conclusion and Recommendations: The spleen dimensions were higher in males than females and have a significant positive correlation with height, weight, Body Mass Index and Body Surface Area except for the width. Further studies in different parts of the country have to be done to have normative data on the dimension of Spleen in Ethiopia.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Morphometric Assessment of Spleen Dimensions and Its Correlates Among Individual Living in Arba Minch Town, Southern Ethiopia

Demissie

Prasad

Fikadu

et al. 2021

Preprint

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“…In this study the mean spleen length was 10.24 cm which is consistent with studies conducted in Russia and Kashmir [ 40 , 41 ]. But, less than from studies conducted in Turkey, Bangladesh, Jordan and North India [ 29 , 42 – 44 ]. It is greater than from studies conducted in Nepal, Nigeria, Sudan and Northern Ethiopia [ 18 , 19 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Morphometric assessment of spleen dimensions and its determinants among individuals living in Arba Minch town, southern Ethiopia

et al. 2021

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Introduction The spleen is a vital lymphoid soft organ that demands constant attention from the clinical point of view. It is a multi-dimensional organ that enlarges in its all dimensions during some disease condition. The detection of the spleen by palpation is not an indicator of an enlarged spleen because normal spleen may be palpable. Therefore, this study aimed to assess the morphometry of spleen dimensions and its determinants among individuals living in Arba Minch town by sonographic examinations. Methods and materials Community-based cross-sectional study was conducted in Arba Minch town from February 1 to March 30, 2020. Seven hundred and eight study participants were selected using a multi-stage systematic random sampling technique. Data were checked for completeness, edited, coded and entered into Epi-Data version 3.1 and exported to STATA software version 16 for analysis. Result The mean splenic length, width, thickness and volume were 10.24 cm, 4.79 cm, 3.93 cm, and 109.34 cm3, respectively. The mean spleen length, width, thickness and volumes among males were 10.64 cm, 4.92 cm, 4.05 cm and 119.81 cm3 and among females were 9.75 cm, 4.63 cm, 3.78 cm and 96.50 cm3 respectively. As age increased by one year the mean spleen length, width, thickness and volume was decreased by 0.032 cm, 0.018 cm 0.004 cm and 0.012 cm respectively. As height increased by 1 cm the mean spleen width and volume were increased by 0.096 cm and 0.052 cm respectively. As we go from male to female the mean spleen length decreased by 0.294 cm. Conclusion The spleen dimensions were higher in males than females. Splenic length was determined by age & sex, the spleen width was determined by age & height, the spleen volume was determined by age & height and the spleen thickness was determined by age.

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Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia

Dao

Gotlib

Deininger

et al. 2020

JCO

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PURPOSE Colony-stimulating factor-3 receptor ( CSF3R)-T618I is a recurrent activating mutation in chronic neutrophilic leukemia (CNL) and to a lesser extent in atypical chronic myeloid leukemia (aCML) resulting in constitutive JAK-STAT signaling. We sought to evaluate safety and efficacy of the JAK1/2 inhibitor ruxolitinib in patients with CNL and aCML, irrespective of CSF3R mutation status. METHODS We conducted a phase II study of ruxolitinib in 44 patients (21 CNL and 23 aCML). The primary end point was overall hematologic response rate (ORR) by the end of 6 continuous 28-day cycles for the first 25 patients enrolled. We considered a response as either partial (PR) or complete response (CR). We expanded accrual to 44 patients to increase our ability to evaluate secondary end points, including grade ≥ 3 adverse events, spleen volume, symptom assessment, genetic correlates of response, and 2-year survival. RESULTS ORR was 32% for the first 25 enrolled patients (8 PR [7 CNL and 1 aCML]). In the larger cohort of 44 patients, 35% had a response (11 PR [9 CNL and 2 aCML] and 4 CR [CNL]), and 50% had oncogenic CSF3R mutations. The mean absolute allele burden reduction of CSF3R-T618I after 6 cycles was greatest in the CR group, compared with the PR and no response groups. The most common cause of death is due to disease progression. Grade ≥ 3 anemia and thrombocytopenia were observed in 34% and 14% of patients, respectively. No serious adverse events attributed to ruxolitinib were observed. CONCLUSION Ruxolitinib was well tolerated and demonstrated an estimated response rate of 32%. Patients with a diagnosis of CNL and/or harboring CSF3R-T618I were most likely to respond.

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Splenic Volume: Correlation between Ultrasonogram and Standard CT Measurements

Cited by 4 publications

References 6 publications

Morphometric Assessment of Spleen Dimensions and Its Correlates Among Individual Living in Arba Minch Town, Southern Ethiopia

Morphometric Assessment of Spleen Dimensions and Its Correlates Among Individual Living in Arba Minch Town, Southern Ethiopia

Morphometric assessment of spleen dimensions and its determinants among individuals living in Arba Minch town, southern Ethiopia

Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia

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