Spontaneous Activity in Primary Visual Cortex Relates to Visual Creativity

Wang, Yibo; Li, Junchao; Wang, Zengjian; Liang, Bishan; Jiao, Bingqing; Zhang, Peng; Huang, Yingying; Yang, Hui; Yu, Rengui; Yu, Sifang; Zhang, De‐Long; Liu, Ming

doi:10.3389/fnhum.2021.625888

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…More recent rsfMRI findings also indicate that spontaneous visual network activity and connectivity to the DMN are related to visual creative cognition (Chen et al, 2019. Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 95%

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Creative tempo: Spatiotemporal dynamics of the default mode network in improvisational musicians

Watters,

Fazili,

Daley

et al. 2024

Preprint

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The intrinsic dynamics of human brain activity display a recurring pattern of anti-correlated activity between the default mode network (DMN), associated with internal processing and mentation, and task positive regions, associated with externally directed attention. In human functional magnetic resonance imaging (fMRI) data, this anti-correlated pattern is detectable on the infraslow timescale (<0.1 Hz) as a quasi-periodic pattern (QPP). While the DMN is implicated in creativity and musicality in traditional time-averaged functional connectivity studies, no one has yet explored how creative training may alter dynamic spatiotemporal patterns involving the DMN such as QPPs. In the present study, we compare the outputs of two QPP detection approaches, sliding window algorithm and complex principal components analysis (cPCA). We apply both methods to an existing dataset of musicians captured with resting state fMRI, grouped as either classical, improvisational, or minimally trained non-musicians. The original time-averaged functional connectivity (FC) analysis of this dataset used improvisation as a proxy for creative thinking and found that the DMN and visual networks (VIS) display higher connectivity in improvisational musicians. We expand upon the original study of this dataset and find that QPP analysis detects convergent results at the group level with both methods. In improvisational musicians, dynamic functional correlation in the group-averaged QPP was found to be increased between the DMN-VIS and DMN-FPN for both the QPP algorithm and complex principal components analysis (cPCA) methods. Additionally, we found an unexpected increase in FC in the group-averaged QPP between the dorsal attention network and amygdala in improvisational musicians; this result was not reported in the original seed-based study of this dataset. The current study represents a novel application of two dynamic FC detection methods with results that replicate and expand upon previous seed-based FC findings. The results show the robustness of both the QPP phenomenon and its detection methods. This study also demonstrates the value of dynamic FC methods in reproducing seed-based findings and their promise in detecting group-wise or individual differences that may be missed by traditional seed-based resting state fMRI studies.

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Section: Discussionmentioning

confidence: 95%

“…Beaty et al, 2015. Such alterations in DMN-FPN or DMN-VAN connectivity may represent an increased capacity for flexible cognitive control driving creativity (Zabelina et al 2018. Li et al, 2021.…”

Section: Introductionmentioning

confidence: 99%

Creative tempo: Spatiotemporal dynamics of the default mode network in improvisational musicians

Watters,

Fazili,

Daley

et al. 2024

Preprint

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“… 62 Better visual creativity was correlated with stronger resting-state FC between the visual network, default mode, and frontoparietal networks. 61 , 63 Although our studies focused on infants, it is plausible that the similar mechanisms are present at some level or are developing in infants. We found that the inter-network connectivity between the visual and DMN exhibited the largest weight, followed by visual-FPN, suggesting potential functional alterations governed by the inter-network connectivity among the three networks in POE infants.…”

Section: Discussionmentioning

confidence: 98%

“…While inter-network connections serve less specialized and complex brain functions when compared to intra-network connections, 58 , 59 inter-network communications have been regarded as essential to maintain healthy executive function. 58 , 59 In particular, growing evidence from adult studies 60 , 61 has supported that the intrinsic neural connections between visual and default mode networks play a key role in visual mental imagery, which is the basis of a variety of high-level cognitive functions. 62 Better visual creativity was correlated with stronger resting-state FC between the visual network, default mode, and frontoparietal networks.…”

Section: Discussionmentioning

confidence: 99%

Neural alterations in opioid-exposed infants revealed by edge-centric brain functional networks

Jiang

Merhar

Zeng

et al. 2022

Brain Communications

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Prenatal opioid exposure has been linked to adverse effects spanning multiple neurodevelopmental domains, including cognition, motor development, attention, and vision. However, the neural basis of these abnormalities is largely unknown. A total of 49 infants, including 21 opioid-exposed and 28 controls, were enrolled and underwent MR imaging (43 ± 6 days old) after birth, including resting state functional MRI. Edge-centric functional networks based on dynamic functional connections were constructed and machine-learning methods were employed to identify neural features distinguishing opioid-exposed infants from unexposed controls. An accuracy of 73.6% (sensitivity 76.25% and specificity 69.33%) was achieved using 10 times ten-fold cross-validation, which substantially outperformed those obtained using conventional static functional connections (accuracy 56.9%). More importantly, we identified that prenatal opioid exposure preferentially affects inter- rather than intra-network dynamic functional connections, particularly with the visual, subcortical and default mode networks. Consistent results at the brain regional and connection levels were also observed, where the brain regions and connections associated with visual and higher order cognitive functions played pivotal roles in distinguishing opioid-exposed infants from controls. Our findings support the clinical phenotype of infants exposed to opioids in utero and may potentially explain the higher rates of visual and emotional problems observed in this population. Finally, our findings suggested that edge-centric networks could better capture the neural differences between opioid-exposed infants and controls by abstracting the intrinsic co-fluctuation along edges, which may provide a promising tool for future studies focusing on investigating the effects of prenatal opioid exposure on neurodevelopment.

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“…We employed a recently developed method to measure the dynamic changes in lateralisation of hemispheres, which used a sliding time window based on a global signal to capture the time‐varying lateralisation architecture (Wu et al, 2022 ). Compared with the traditional method of measuring lateralisation using SFC (Liu et al, 2009 ), this new method took full advantage of the abundant dynamic properties in spontaneous brain activity, which were also essential for exploring creative idea generation (Agnoli et al, 2018 ; Wang et al, 2021 ). In this study, 12‐network parcellation with 360 bilateral parcels was applied to define the nodes (Glasser et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

The unity and diversity of verbal and visuospatial creativity: Dynamic changes in hemispheric lateralisation

Gao,

Wu,

Yan

et al. 2023

Human Brain Mapping

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The investigation of similarities and differences in the mechanisms of verbal and visuospatial creative thinking has long been a controversial topic. Prior studies found that visuospatial creativity was primarily supported by the right hemisphere, whereas verbal creativity relied on the interaction between both hemispheres. However, creative thinking also involves abundant dynamic features that may have been ignored in the previous static view. Recently, a new method has been developed that measures hemispheric laterality from a dynamic perspective, providing new insight into the exploration of creative thinking. In the present study, dynamic lateralisation index was calculated with resting‐state fMRI data. We combined the dynamic lateralisation index with sparse canonical correlation analysis to examine similarities and differences in the mechanisms of verbal and visuospatial creativity. Our results showed that the laterality reversal of the default mode network, fronto‐parietal network, cingulo‐opercular network and visual network contributed significantly to both verbal and visuospatial creativity and consequently could be considered the common neural mechanisms shared by these creative modes. In addition, we found that verbal creativity relied more on the language network, while visuospatial creativity relied more on the somatomotor network, which can be considered a difference in their mechanism. Collectively, these findings indicated that verbal and visuospatial creativity may have similar mechanisms to support the basic creative thinking process and different mechanisms to adapt to the specific task conditions. These findings may have significant implications for our understanding of the neural mechanisms of different types of creative thinking.

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Spontaneous Activity in Primary Visual Cortex Relates to Visual Creativity

Cited by 8 publications

References 42 publications

Creative tempo: Spatiotemporal dynamics of the default mode network in improvisational musicians

Creative tempo: Spatiotemporal dynamics of the default mode network in improvisational musicians

Neural alterations in opioid-exposed infants revealed by edge-centric brain functional networks

The unity and diversity of verbal and visuospatial creativity: Dynamic changes in hemispheric lateralisation

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