Spontaneous and Experimentally Induced Uptake of Radioactive Iodine in Metastases From Thyroid Carcinoma: A Preliminary Report*†

Seidlin, S. M.; Oshry, Eleanor; Yalow, A. Aaron

doi:10.1210/jcem-8-6-423

Cited by 72 publications

(18 citation statements)

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“…It has been reported that there are "cold" thyroid nodules which are apparently follicular in origin (SEIDLIN et al, 1948;VALENTA et al, 1968). These cold nodules show the low basal radioactive iodine accumulation.…”

Section: Discussionmentioning

confidence: 99%

Fine structural aspects on the cold follicles in the aged mouse thyroid.

Tamura

Fujita

1981

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionmentioning

confidence: 99%

Fine structural aspects on the cold follicles in the aged mouse thyroid.

Tamura

Fujita

1981

Arch. Histol. Jap., Arch. Histol. Jpn

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“…A small percentage are malignant. Many are of apparent follicular cell origin and retain a potential for hormonogenesis (9,10). Despite histologic similarity to the normal surrounding thyroid tissue, the low basal radioactive iodide accumulation of cold nodules and their unresponsiveness to TSH administration suggest the presence of significant metabolic differences.…”

mentioning

confidence: 99%

Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of “cold” thyroid nodules and normal human thyroid tissue

DeRubertis¹,

Yamashita²,

Dekker³

et al. 1972

J. Clin. Invest.

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A B S T R A C T "Cold" thyroid nodules do not concentrate 3"I before or after thyrotropin (TSH) administration. In an attempt to elucidate the reason for this TSH unresponsiveness, the effect of TSH in vitro on several metabolic parameters was studied in 11 "cold" thyroid adenomas, 2 medullary carcinomas, and in the surrounding normal thyroid tissue. Basal adenyl cyclase activity, glucose-1-`4C oxidation, and 3P incorporation into phospholipids were significantly greater in the adenomas than in the adjacent normal thyroid; basal cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentration and adenine-'H incorporation into 'H-labeled cyclic AMP were not different. In adenomas as well as normal thyroid, all parameters responded significantly to in vitro TSH stimulation. The response to TSH of adenyl cyclase activity and 8P incorporation was enhanced in adenomas compared with that of the adjacent normal thyroid. These differences were not explained by an increased cellularity of the adenomas. Medullary carcinomas did not respond to TSH in any of the above parameters.The studies demonstrate an intact, TSH-responsive adenyl cyclase-cyclic AMP system in the adenomas and, accordingly, imply the presence of receptor sites for TSH on the cells of the adenoma. The failure of such nodules to concentrate '31I may be owing to a subsequent impairment in the expression of cyclic AMP action on iodine metabolism.

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“…In three cases, there was a measurable iodine uptake in the secondaries. SEIDLIN, OSHRY and YALOW (37) found iodine uptake in eight of 14 cases of metastasizing thyroid carcinoma. Studying 21 cases of thyroid carcinoma, RAWSON et alii (34) found iodine uptake in the primary tumour in 10 and in the secondaries in eight.…”

Section: Kaae and Olap Petehsenmentioning

confidence: 95%