Spontaneous chromosome mutation and screening of mutator factors in Drosophila melanogaster

An analysis of spontaneous recombination in Drosophila melanogaster males

“…Although it was originally thought that this population was exceptional, it is now becoming clear that strains of D. melanogaster that show male recombination are not rare. Such strains have been identified in 10 states of the U.S.A. (Hiraizumi, 1971;Voelker, 1974;Waddle and Oster, 1974;Yamaguchi and Mukai, 1974;Kidwell, 1975a, 1975b;Slatko, personal communication), in Australia (Sved, 1974(Sved, , 1976, in Greece (Pelecanos and Yannopoulos, personal communication), and in Yugoslavia, Japan, and Taiwan (Yamaguchi, 1976). Our report extends this list to include Oklahoma, U.S.A., and Cambridge, England.…”

“…Mutator activity, segregation distortion, and sterility seem to be associated with male recombination in some lines (Slatko and Hiraizumi, 1973;Sved, 1974Sved, , 1976Voelker, 1974;Kidwell and Kidwell, 1975b;Yamaguchi, 1976). Finally, there seems to be a cytoplasmic-chromosomal interaction that can affect the frequency of male recombination (Kidwell and Kidwell, 1975a).…”

Chromosome breakage: A possible mechanism for diverse genetic events in outbred populations

“…Recombination in outcrossed D. melanogaster males, which was first reported by Hiraizumi in 1971, has now been reported in numerous populations world wide (Hiraizumi, 1971;Hiraizumi, et al, 1973;Hiraizumi, 1973, 1975;Voelker, 1974;Waddle and Oster, 1974;Yamaguchi and Mukai, 1974;Cardellino and Mukai, 1975;Kidwell, 1975a, l975b, 1976;Sochacka and Woodruff, 1976;Sved, 1976;Yamaguchi, 1976;Woodruff and Thompson, l977a). In contrast, most laboratory mutant and wild type lines, such as the commonly used Canton-S wild type, do not undergo recombination in heterozygous males (Slatko and Hiraizumi, 1973;Kidwell and Kidwell, 1 975a;Woodruff and Thompson, 1977a).…”

“…1. Hiraizumi (e.g., Hiraizumi, et al, 1973) and others (Voelker, 1974;Yamaguchi and Mukai, 1974;Cardellino and Mukai, 1975;Yamaguchi, 1976), for example, have suggested that male recombination may be caused by chromosome breakage and reunion. It is certainly clear that many natural populations which show male recombination when outcrossed to marker stocks also undergo frequent chromosome breakage.…”

“…Many outcrossed natural populations have been observed to show mutator activity or the induction of unique chromosome rearrangements (Minamori and Ito, 1971;Slatko and Hiraizumi, 1973;Voelker, 1974;Yamaguchi and Mukai, 1974;Cardellino and Mukai, 1975;Yamaguchi, 1976;Kidwell, Kidwell, and Ives, 1977). When tested, they often show the other events associated with hybrid dysgenesis.…”