Spontaneous Coronary Artery Dissection: A Comprehensive Overview

Hussein, Mohamed Toufic El; Blayney, Sarah

doi:10.1016/j.jen.2020.05.012

Cited by 6 publications

(20 citation statements)

References 38 publications

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“…Because SCAD affects young women not otherwise presenting with traditional cardiovascular disease risk factors, it has recently gained considerable attention among researchers and practitioners. Available evidence indicates that women account for 87% to 95% of all recorded SCAD cases, 4 and 35% of MI in young women are ascribed to SCAD. 20 , 28 , 29 The affected patients typically present with chest pain (describing it as crushing pressure or sharp pain), but may also report back pain, hypertension, and/or shortness of breath.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas SCAD primarily affects women (who account for 87%−95% of all known cases) 4 and more frequently presents in younger women (aged <50 years), 5 it is routinely misdiagnosed if no cardiac risk factors are present because women are typically not considered at high risk for developing cardiovascular issues. 6 Given that pregnancy exacerbates the SCAD risk as well as its severity, 7 its timely diagnosis and treatment are critical.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy-Associated Spontaneous Coronary Artery Dissection in Women: A Literature Review

Zeven¹

2023

Current Therapeutic Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy-Associated Spontaneous Coronary Artery Dissection in Women: A Literature Review

Zeven¹

2023

Current Therapeutic Research

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“…SCAD is defined as an epicardial coronary artery dissection that is not associated with atherosclerosis or trauma and is not iatrogenic. [ 3 ] The predominant mechanism of myocardial injury occurring due to SCAD is coronary artery obstruction provoked by the formation of a spontaneous intramural hematoma (IMH) or intimal disruption. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy-related SCAD is the most difficult to treat among all SCAD presentations and the one most likely to be associated with disastrous complications. [ 3 4 ] Although the pathophysiology and etiology are unknown, hormonal changes during pregnancy may be the reason for structural changes in the vessel wall, including loss of elastic fibers and a decrease in acid mucopolysaccharides. [ 5 ] Other factors, such as hemodynamic stress and changes in the autoimmune status, have also been considered as possible etiological factors.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-Related Spontaneous Coronary Artery Pseudoaneurysm Healed by Medical Treatment Guided by Optical Coherence Tomography

Subbramaniyam¹,

Yousif²,

Shivappa³

et al. 2022

Heart Views

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Spontaneous coronary artery dissection (SCAD) is an uncommon cause of acute myocardial ischemia. SCAD complicated by coronary artery aneurysm (CAA) is rare and seldom reported. Coronary angiography is the gold standard for the diagnosis of SCAD. However, an obscure intimal flap may not be recognized with a conventional coronary angiogram, and intravascular imaging modalities are important in the diagnosis of SCAD. Optical coherence tomography contributes to providing information about the size, shape, and location of CAAs. Herein, we are presenting a challenging and unique case of a woman presenting with SCAD complicated by a CAA.

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“…Spontaneous coronary artery dissection (SCAD) is a rare event with an incidence of approximately 0.28–1.1% and occurs most commonly in women ( 18 ). In SCAD associated with atherosclerosis, inflammation and rupture of atherosclerotic plaque cause disruption of the intimal-medial junction of the artery and result in a false lumen in the arterial wall.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of Associations of Circulating Molecules With Spontaneous Coronary Artery Dissection and Aortic Aneurysm and Dissection

Chai

Tian

Yang

et al. 2022

Front. Cardiovasc. Med.

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Circulating proteins play functional roles in various biological processes and disease pathogenesis. The aim of this study was to highlight circulating proteins associated with aortic aneurysm and dissection (AAD) and spontaneous coronary artery dissection (SCAD). We examined the associations of circulating molecule levels with SCAD by integrating data from a genome-wide association study (GWAS) of CanSCAD and 7 pQTL studies. Mendelian randomization (MR) analysis was applied to examine the associations between circulating molecule levels and AAD by using data from UK Biobank GWAS and pQTL studies. The SCAD-associated SNPs in 1q21.2 were strongly associated with circulating levels of extracellular matrix protein 1 (ECM1) and 25 other proteins (encoded by CTSS, CAT, CNDP1, KNG1, SLAMF7, TIE1, CXCL1, MBL2, ESD, CXCL16, CCL14, KCNE5, CST7, PSME1, GPC3, MAP2K4, SPOCK3, LRPPRC, CLEC4M, NOG, C1QTNF9, CX3CL1, SCP2D1, SERPINF2, and FN1). These proteins were enriched in biological processes such as regulation of peptidase activity and regulation of cellular protein metabolic processes. Proteins (FGF6, FGF9, HGF, BCL2L1, and VEGFA) involved in the Ras signaling pathway were identified to be related to AAD. In addition, SCAD- and AAD-associated SNPs were associated with cytokine and lipid levels. MR analysis showed that circulating ECM1, SPOCK3 and IL1b levels were associated with AAD. Circulating levels of low-density lipoprotein cholesterol and small very-low-density lipoprotein particles were strongly associated with AAD. The present study found associations between circulating proteins and lipids and SCAD and AAD. Circulating ECM1 and low-density lipoprotein cholesterol may play a role in the pathology of SCAD and AAD.

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Spontaneous Coronary Artery Dissection: A Comprehensive Overview

Cited by 6 publications

References 38 publications

Pregnancy-Associated Spontaneous Coronary Artery Dissection in Women: A Literature Review

Pregnancy-Associated Spontaneous Coronary Artery Dissection in Women: A Literature Review

Pregnancy-Related Spontaneous Coronary Artery Pseudoaneurysm Healed by Medical Treatment Guided by Optical Coherence Tomography

Genome-Wide Identification of Associations of Circulating Molecules With Spontaneous Coronary Artery Dissection and Aortic Aneurysm and Dissection

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