Spontaneous regression of a primary cutaneous diffuse large B‐cell lymphoma, leg type

Jimura, Nozomi; Fujii, Kazuyasu; Baba, Atsunori; Higashi, Yuko; Kanekura, Takuro

doi:10.1111/1346-8138.13496

Cited by 13 publications

(11 citation statements)

References 4 publications

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“…Interestingly, all biopsies performed after SR revealed a T-cell infiltrate. In case 1 the T cells were predominantly CD8 + , in case 2 CD4 + and CD8 + T-cells were found, and in case 3 the CD3 + mature T-cells were not specified further (1)(2)(3). The current case also revealed a predominantly CD8 + T-cell infiltrate.…”

Section: Discussionmentioning

confidence: 45%

Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

Toberer¹,

Mechtersheimer²,

Jaschinski³

et al. 2018

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 45%

Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

Toberer¹,

Mechtersheimer²,

Jaschinski³

et al. 2018

Acta Derm Venerol

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“…In another postulated mechanism of SR in plasmablastic lymphoma, mobilization of the immune system against infection with the Epstein–Barr virus caused tumor regression [ 20 ]. A traumatic intervention such as a biopsy can also induce a regional increase in immune system activity and secondary antitumoral activity with subsequent SR [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The antitumoral activity of the immune system is believed to be mediated through cytotoxic T lymphocytes [ 21 , 22 ]. A case report of SR in a patient with diffuse large B-cell lymphoma involving the right breast suggested that CD8-positive T cells might have contributed to the regression [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of mantle cell lymphoma: a report of four cases

Desai

Gong

et al. 2018

Cancer Communications

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BackgroundSpontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients can exhibit indolent clinical behavior. To date, complete spontaneous regression of MCL has not been reported.Case presentationWe describe four cases of spontaneous regression of MCL. At the time of presentation, these patients were asymptomatic, with lymph node enlargement and mild to moderate fluorodeoxyglucose (FDG) uptake on FDG-positron emission tomography combined with computed tomography. One of the possible mechanisms of spontaneous regression of the tumor could be due to the host immune response through humoral and cellular immunity, which may have a role in the clearance of tumor cells.ConclusionsIn this report, we support the use of a “wait and watch” strategy for MCL patients with no risk factors and indolent behavior. This strategy helps spare patients from further potentially harmful chemotherapy. In addition, we describe the phenomenon of spontaneous regression in MCL patients who are asymptomatic and have low-volume disease.

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“…Although there has been reports showed that PCDLBCL can be spontaneously relieved without treatment, [ 21 ] it is a kind of malignant tumor and can spread to other part of the body. So once the diagnosis is achieved, it should be given active treatment.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery

Jia

Zheng

2017

Medicine

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Rationale:The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP (A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed.Patient concerns:The patient was a 56-year-old female, presenting with red plaques and nodules in her left breast for 6 months.Diagnoses:Based on the clinical manifestation, histopathological and immunohistochemical results, the patient was diagnosed with PCDLBCL-O.Interventions:She was treated with 6 courses of R-CHOP chemotherapy combined with surgical resection.Outcomes:In the present case, fairly good curative effect was appeared with no recurrence within the 3 years’ follow-up.Lessons:Primary cutaneous diffuse large B cell lymphoma commonly occurs on the legs (leg type), rarely on other sites of the body. The clinical manefestations are so variant that its diagnosis depends on histopathological and immunohistochemical examinations. Like systemic diffuse large B cell lymphoma, patients should be treated with systemic chemotherapy.

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Spontaneous regression of a primary cutaneous diffuse large B‐cell lymphoma, leg type

Cited by 13 publications

References 4 publications

Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

Spontaneous regression of mantle cell lymphoma: a report of four cases

Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery

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