Spontaneous Regression of Primary Diffuse Large B-Cell Lymphoma, Leg Type

Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

“…Interestingly, all biopsies performed after SR revealed a T-cell infiltrate. In case 1 the T cells were predominantly CD8 + , in case 2 CD4 + and CD8 + T-cells were found, and in case 3 the CD3 + mature T-cells were not specified further (1)(2)(3). The current case also revealed a predominantly CD8 + T-cell infiltrate.…”

Effectiveness of lenalidomide in relapsed primary cutaneous diffuse large B‐cell lymphoma, leg type

“…Spontaneous remission of PCDLBCL‐LT is extremely rare, and it was reported in five cases . The cause of this spontaneous regression in unknown, and it has been described as a result of probable response of immune system to bacterial or viral infection, or traumatic causes including biopsies, or apoptosis or particular condition of the tumor microenvironment as well .…”

Spontaneous resolution of untreated diffuse large B‐cell lymphoma of maxillary bone after incisional biopsy

“…The mechanism of regression in lymphoma is postulated to be immune‐mediated secondary to activation from viruses like Epstein‐Barr virus versus local trauma from a biopsy . This has been documented in primary cutaneous DLBCL of the leg, as well as DLBCL of the bladder, breast, and conjunctiva . Extranodal onset may confer a greater likelihood of spontaneous regression .…”