Spontaneous Resolution and Super-coiling in Xerogels of the Products of Photo-Induced Formose Reaction

Стовбун, С. В.; Zanin, A. M.; Шашков, М. В.; Скоблин, А. А.; Zlenko, Dmitry V.; Твердислов, В. А.; Михалева, М.Г.; Taran, Oxana P.; Parmon, Valentin N.

doi:10.1007/s11084-019-09583-8

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…Moreover, formation of the strings by TFAAAs can be accompanied by the spontaneous resolution of the enatiomers 44 . Similar helical structures were found in the solutions of carbohydrates 31 and aminoacids 45 . Therefore, based on the observations listed above, we can put forward the hypothesis that the chirally-induced spin selectivity and the related effects driven by the exchange interactions could have been playing a significant role in the germination and development of Life on Earth 31 , 32 .…”

supporting

confidence: 76%

supporting

confidence: 76%

“…The latter was in part demonstrated for small and chiral, but not helical molecule of the amino acid cysteine 29 . The problem of the enantiomers segregation is one of the crucial problems of the Life development on Earth [30][31][32] , and the magnetic field driven segregation can be one of the possible solutions. Therefore, the influence of the magnetic field on the processes of the self-organizing in chiral systems has some additional fundamental sense.…”

mentioning

confidence: 99%

“…Therefore, based on the observations listed above, we can put forward the hypothesis that the chirally-induced spin selectivity and the related effects driven by the exchange interactions could have been playing a significant role in the germination and development of Life on Earth 31 , 32 .…”

mentioning

confidence: 99%

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The weak magnetic field inhibits the supramolecular self-ordering of chiral molecules

Стовбун

Zanin

Скоблин

et al. 2020

Sci Rep

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The magnetic field can affect processes in the non-magnetic systems, including the biochemical reactions in the living cells. This phenomenon becomes possible due to the fermionic nature of an electron and significant energy gain provided by the exchange interactions. Here we report the inhibition effect of the magnetic field on the processes of the chiral supramolecular, i.e., macroscopic self-ordering in the non-magnetic model system. The observed effect is in tune with the reports on the influence of the magnetic field on the adsorption of the chiral molecules, which was explained by the effect of the chirally-induced spin-selectivity and the inhibition of the chemical reactions caused by the singlet-triplet conversion. The magneto sensitivity of the process of the chiral self-ordering directly indicates its spin-polarization nature. Tacking together all of the results in the field, we can propose that the chirality-driven exchange interactions guide the selection of the chiral molecules and explain their prevalence in the living matter. It is also probable that these forces have played a critical role in the origin of life on Earth.

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supporting

confidence: 76%

supporting

confidence: 76%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The weak magnetic field inhibits the supramolecular self-ordering of chiral molecules

Стовбун

Zanin

Скоблин

et al. 2020

Sci Rep

Self Cite

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“…The so-called "spontaneous resolution" can be proposed as a cooperative mechanism for justifying the chiral recognition of phenylalanine amino acid (Zlenko et al, 2019b). According to this fascinating theory, the separation of two enantiomers could be obtained as amplification of the initial asymmetry under the effect of some chemical compounds already present in the system (Stovbun et al, 2019). Furthermore, an additional effect could be represented by the spin polarization that was demonstrated to play an important role in the chiral biomolecular interactions (Kumar et al, 2017;Dalum and Hedegård, 2019;Naaman et al, 2019).…”

Section: Disaggregation Process Of D-pbi Aqueous Solution In Presencementioning

confidence: 99%

Supramolecular Chiral Discrimination of D-Phenylalanine Amino Acid Based on a Perylene Bisimide Derivative

Bettini

Syrgiannis

Ottolini

et al. 2020

Front. Bioeng. Biotechnol.

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The interaction between homochiral substituted perylene bisimide (PBI) molecule and the D enantiomer of phenylalanine amino acid was monitored. Spectroscopic transitions of PBI derivative in aqueous solution in the visible range were used to evaluate the presence of D-phenylalanine. UV-visible, fluorescence, FT-IR, and AFM characterizations showed that D-phenylalanine induces significant variations in the chiral perylene derivative aggregation state and the mechanism is enantioselective as a consequence of the 3D analyte structure. The interaction mechanism was further investigated in presence of interfering amino acid (D-serine and D-histidine) confirming that both chemical structure and its 3D structure play a crucial role for the amino acid discrimination. A D-phenylalanine fluorescence sensor based on perylene was proposed. A limit of detection (LOD) of 64.2 ± 0.38 nM was calculated in the range 10 −7 -10 −5 M and of 1.53 ± 0.89 µM was obtained in the range 10 −5 and 10 −3 M.

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Step‐by‐Step Towards Biological Homochirality – from Prebiotic Randomness To Perfect Asymmetry

Mejdrová,

Węgrzyn,

Carell

2024

Chemistry An Asian Journal

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The history of life’s formation and the origin of its stereochemistry are nearly as multifaceted as the life itself. In this review, we focus on analyzing the step‐by‐step path leading to what we can define as “life” in parallel to what we know about the emergence of enantiomeric imbalance and subsequent transition to full homochirality. We start at the level of assembly of the building blocks of life from inorganic molecules and build up to the polymerization and formation of nucleic acids and peptides. We report and analyze different theories at various stages of this development and try to elucidate the most plausible theory.

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Spontaneous Resolution and Super-coiling in Xerogels of the Products of Photo-Induced Formose Reaction

Cited by 10 publications

References 37 publications

The weak magnetic field inhibits the supramolecular self-ordering of chiral molecules

The weak magnetic field inhibits the supramolecular self-ordering of chiral molecules

Supramolecular Chiral Discrimination of D-Phenylalanine Amino Acid Based on a Perylene Bisimide Derivative

Step‐by‐Step Towards Biological Homochirality – from Prebiotic Randomness To Perfect Asymmetry

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