Spontaneous, Surgically and Chemically Induced Models of Disease

Health biomarkers in a rat model after intake of organically grown carrots

“…The GK/MolTac rat strain was chosen due to its potential for developing diet‐related type 2 diabetes,34 since potentially challenged reporter systems might be more susceptible than a normal healthy reporter system 13. AP, NEFA, TAG and cholesterol concentrations and the elevated glucose level of the GK/MolTac model were not reduced nor increased by any of the diets; hence, the cultivations systems seemed to have no effect on the development of diabetes.…”

Obesity Rodent Models Applied to Research with Food Products and Natural Compounds

“…Defects in the leptin receptor caused by this mutation result in the development of early-onset obesity due to hyperphagia, reducing the energy expenditure and leading to morbid obesity [14]. These rats are less likely to acquire diabetes, although ZFR has a high level of insulin resistance and fertility is reduced [14,20] The ZFR is the most used model for studying several genetic characteristics associated with obesity [33,34], although it has also been used to study the anti-obesogenic effects of natural compounds such as the extracts of red wine [35], rosemary [36], green tea [37], bilberries, and purple potatoes [38] (Table 1).…”

Animal Models as Tools for Translational Research: Focus on Atherosclerosis, Metabolic Syndrome and Type-II Diabetes Mellitus

“…The female ZDF rat is unique in that while they are obese, they do not develop diabetes unless fed a diet (in this case, chowbased) containing 48 kcal% fat [50]. The female ZDF rat is also suitable model mimics prediabetic state in humans because she shows a prolonged period of insulin sensitivity prior to the onset of diet-induced diabetes [51]. The ZDF rats show profound dyslipoproteinaemia with increased TC and TGs levels and lower chylomicra disposal rates that mimics conditions occurred in human case of obesity [52].…”