Sporadic feeding regulates robust food entrainable circadian clocks in blind cavefish

Di Rosa, Viviana; Frigato, Elena; Negrini, Pietro; Cristiano, Walter; López-Olmeda, Jose Fernando; Rétaux, Sylvie; Sánchez-Vázquez, Francisco Javier; Foulkes, Nicholas S.; Bertolucci, Cristiano

doi:10.1016/j.isci.2024.110171

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Daily rhythms of locomotor activity and transcript levels of non-visual opsins in the brain of the blind Mexican cavefish (Astyanax mexicanus)

Conti,

Vergès-Castillo,

Sánchez-Vázquez

et al. 2025

Comparative Biochemistry and Physiology Part A: Molecular &

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Daily rhythms of locomotor activity and transcript levels of non-visual opsins in the brain of the blind Mexican cavefish (Astyanax mexicanus)

Conti,

Vergès-Castillo,

Sánchez-Vázquez

et al. 2025

Comparative Biochemistry and Physiology Part A: Molecular &

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A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms

Swaminathan,

Kenzior,

McCoin

et al. 2024

Preprint

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The repeated evolution of similar phenotypes in independent lineages often occurs in response to similar environmental pressures, through similar or different molecular pathways. Recently, a repeatedly occurring mutation R263Q in a conserved domain of the protein Cryptochrome1 (CRY1) was reported in multiple species inhabiting subterranean environments. Cryptochromes regulate circadian rhythms, and glucose and lipid metabolism. Subterranean species show changes to their circadian rhythm and metabolic pathways, making it likely that this mutation in CRY1 contributes to adaptive phenotypic changes. To identify the functional consequences of the CRY1 R263Q mutation, we generated a mouse model homozygous for this mutation. Indirect calorimetry experiments revealed delayed energy expenditure, locomotor activity and feeding patterns of mutant mice in the dark phase, but no further metabolic phenotypes, unlike a full loss of function of CRY1. Gene expression analyses showed altered expression of several canonical circadian genes in the livers of the mutant mice, fortifying the notion that CRY1 R263Q impacts metabolism. Our data provide the first characterization of a novel mutation that has repeatedly evolved in subterranean environments, supporting the idea that shared environmental constraints can drive the evolution of similar phenotypes through similar genetic changes.

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Sporadic feeding regulates robust food entrainable circadian clocks in blind cavefish

Cited by 2 publications

References 56 publications

Daily rhythms of locomotor activity and transcript levels of non-visual opsins in the brain of the blind Mexican cavefish (Astyanax mexicanus)

Daily rhythms of locomotor activity and transcript levels of non-visual opsins in the brain of the blind Mexican cavefish (Astyanax mexicanus)

A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms

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