Sporadic Primary Hyperparathyroidism in Young Individuals: Different Disease and Treatment?

Sneider, Mark S.; Solórzano, Carmen C.; Montano, Raquel E.; Anello, Charles; Irvin, George L.; Lew, John I.

doi:10.1016/j.jss.2008.07.041

Cited by 34 publications

(30 citation statements)

References 7 publications

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“…Several series have found that children tend to present with more severe symptomatology including evidence of end-organ damage (ie, nephrolithiasis, pancreatitis, osteitis cystica, and hypercalcemic crisis), which is likely a result of higher serum calcium level at presentation [7,11]. Despite these findings, the diagnosis of hyperparathyroidism in children is often delayed, probably because of underrecognition owing to its clinical rarity in this population and often nonspecific symptoms [12].…”

Section: Discussionmentioning

confidence: 99%

What is the optimal treatment for children with primary hyperparathyroidism?

Durkin

Nichol

Lund

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

What is the optimal treatment for children with primary hyperparathyroidism?

Durkin

Nichol

Lund

et al. 2010

Journal of Pediatric Surgery

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“…The literature for pediatric PHPT is mixed, with several studies reporting male predominance, especially in younger age groups, as a difference between pediatric and adult presentations of the disease. 4,10,12 A pooled review of available literature in 2012 of youth and adolescent PHPT reports an overall slight female predominance, with an increase in the number of female patients starting in the 21 to 30 age range. 7 There were a total of 14 patients (35%) over the age of 21 in our cohort, and the slight female dominance remained in our population when stratified by age.…”

Section: Commentsmentioning

confidence: 99%

“…8,9 In addition, the literature further supports that parathyroid surgery in young patients with PHPT is safe and effective. 6,7,10–12 The aims of this study were to determine how PHPT is currently being diagnosed in young patients, and to assess characteristics and outcomes of parathyroid surgery in this population. We hypothesized that there has been a change over time in how young patients are being diagnosed with PHPT at our institution.…”

mentioning

confidence: 99%

The changing pattern of diagnosing primary hyperparathyroidism in young patients

Lou

Sippel

Chen

et al. 2017

The American Journal of Surgery

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Background Primary hyperparathyroidism (PHPT) is increasing in adults but rarely reported in young patients where routine blood work is obtained more judiciously. We aim to determine how PHPT is currently being diagnosed in young patients and examine surgical outcomes. Method We retrospectively analyzed PHPT patients 24 years of age or less who underwent parathyroidectomy from 2001 to 2014. Patients were divided into 2 time periods: 2001 to 2007 (A) and 2008 to 2014 (B). Incidentally, diagnosed patients lacked objective symptoms of PHPT and had no family history. Results Forty young patients met inclusion criteria: 16 in group A and 24 in group B. Those in group A compared with group B had similar mean age, preoperative calcium, and parathyroid hormone (P > .05). Incidental diagnosis was more common in the contemporary group (42% vs 25%, P = .001). Conclusions Current diagnosis of PHPT in young patients is increasingly incidental. This trend may be attributed to the more liberal use of labs in younger patients.

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“…Therefore, size and/or morphology of the glands are not the only indicator of multiple abnormally secreting glands. As intraoperative PTH assay allows diagnosis of abnormal functioning glands, the rate of MGD in pHPT diagnosed decreased since introduction of intraoperative PTH assay from 15-20% to 5-7% [12]. In our institution 7% of all patients operated on for pHPT in a period of 72 months (105 patients) were diagnosed to have MGD.…”

Section: Discussionmentioning

confidence: 82%