Spore germination, colony development, and secondary metabolism in Penicillium brevicompactum: a radiogas chromatographic and morphological study

Abstract

A study of the first 76 h of development of spores of Penicillium brevicompactum in batch-mode shake culture indicates that mycophenolic acid biosynthesis begins when the hyphae of germinating spores aggregate to form pellets. Supplies of mycophenolic acid so produced augment a pre-existing pool of the material that is associated with the dormant spore. Although acetate metabolism is active at all stages of development, incorporation of [1-(14)C]acetate into 2,4-dihydroxy-6-(1',2'-dioxopropyl)benzoic acid, another secondary metabolite of the fungus, could not be demonstrated. The significance of these data are considered in terms of the function of mycophenolic acid and the substituted benzoic acid in the producing organism.

Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi

“…Many of these alkaloids have been found to show a variety of biological activity including insecticidal, cytotoxic, anthelmintic, calmodulin inhibition, 31 osteoclast inhibition, and antibacterial properties. 1–3,5,8–30,32–34 Reviews in this area have included the studies on the discovery of unexpected enantiomeric and diastereomeric relationships (Fig. 2) (see Section 2) as well as developments in the biosynthesis of these compounds (see Section 3), and biomimetic total syntheses (see Section 4).…”

Fungal Secondary Metabolism Research: Past, Present and Future

“…Several reports have already appeared of how we have used rgc/ms in pursuit of both fungal secondary metabolic and of more general ends (39,(44)(45)(46)(47). Space does not permit inclusion of any significant amount of new material.…”