Sporotrichosis: Recurrent Cutaneous, Articular, and Central Nervous System Infection in a Renal Transplant Recipient

Gullberg, Robert M.; Quintanilla, A.; Levin, Murray L.; Williams, James M.; Phair, John P.

doi:10.1093/clinids/9.2.369

Cited by 68 publications

(36 citation statements)

References 30 publications

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“…This increase is due in part to better diagnostic techniques and greater awareness of the possibility of fungal invasion of the nervous system, but the increase can also be attributed to a growing pool of severely compromised hosts. Besides AIDS, other conditions such as diabetes, alcoholism, granulomatous diseases, cirrhosis, renal transplantation, malignancies, corticosteroids, and use of immunosuppressive agents are commonly reported in patients with extracutaneous sporotrichosis (72,82,85). HIV-infected patients with preserved immunity seem to respond to infection by Sporothrix schenckii in the same way as individuals without coinfection (220).…”

Section: Pathogenesis and Clinical Forms Human Diseasementioning

confidence: 99%

Sporothrix schenckii and Sporotrichosis

Barros

Paes²,

Schubach³

2011

Clin Microbiol Rev

531

677

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SUMMARY Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii , is currently distributed throughout the world, especially in tropical and subtropical zones. Infection generally occurs by traumatic inoculation of soil, plants, and organic matter contaminated with the fungus. Certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis. Zoonotic transmission has been described in isolated cases or in small outbreaks. Since the end of the 1990s there has been an epidemic of sporotrichosis associated with transmission by cats in Rio de Janeiro, Brazil. More than 2,000 human cases and 3,000 animal cases have been reported. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. In cats, the disease can evolve with severe clinical manifestations and frequent systemic involvement. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches have been recently adopted as auxiliary tools for the diagnosis of this mycotic infection. The first-choice treatment for both humans and cats is itraconazole.

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Section: Pathogenesis and Clinical Forms Human Diseasementioning

confidence: 99%

Sporothrix schenckii and Sporotrichosis

Barros

Paes²,

Schubach³

2011

Clin Microbiol Rev

531

677

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“…Infections caused by dimorphic fungi, rarely observed in a temperate climate, may have a chronic or disseminated clinical course in immunocompromised patients [10,11].…”

Section: Discussionmentioning

confidence: 99%

Infection by a Dimorphic Fungus Sporothrix schenckii in an Immunocompromised Patient

et al. 2005

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Infections caused by dimorphic fungi, rarely observed in a temperate climate, may cause chronic infections in immunocompromised patients. We describe a case of sporotrichosis in a 50-year-old woman, who underwent mastectomy due to breast carcinoma, followed by radiation and chemotherapy. She developed skin lesions, localized along the lymphatics. Discharge samples repeatedly yielded a characteristic growth of the dimorphic fungus Sporothrix schenckii. The isolate was resistant to all commonly used antifungal agents, except for itraconazole. Therapy with this antifungal agent resulted in disappearance of the clinical symptoms.

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“…Choroba może szerzyć się poprzez układ krwionośny, obejmując skórę całego ciała [5]. Sporotrychoza może mieć też przebieg układowy, zmiany mogą zajmować nie tylko płuca i skórę, lecz także kości, stawy, mięśnie i każdy inny narząd [47]. Obie rozsiane postaci sporotrychozy -skórna i pozaskór-na -są coraz częściej obserwowane u pacjentów po przeszczepach narządów.…”

Section: Sporotrychozaunclassified

Superficial and deep cutaneous fungal infections in solid organ transplant recipients

Olszewska¹,

Imko-Walczuk²,

Nowicki³

et al. 2016

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StreSzczenieWraz ze wzrostem liczby przeprowadzanych transplantacji zwiększa się liczba osób z obniżoną odpornością. Leczenie immunosupresyjne predysponuje do rozwoju infekcji grzybiczych, które są przyczyną nie tylko niepowodzeń transplantacyjnych, lecz także zgonów wśród biorców przeszczepów. Nietypowy obraz kliniczny wywołany immunosupresją utrudnia diagnostykę grzybic. Leczenie infekcji grzybiczych u pacjentów po przeszczepieniu jest problematyczne ze względu na oporność grzybów na powszechnie stosowane leki, interakcje lekowe oraz konieczność kontynuowania immunosupresji w celu uniknięcia odrzucenia przeszczepionego narządu. Niniejsza praca stanowi przegląd piśmiennictwa dotyczącego zakażeń grzybiczych powierzchownych i głębokich w obrębie skóry oraz metod diagnostycznych i leczniczych u osób po przeszczepieniach narządów. Niektóre grzybicze zmiany skórne mogą być manifestacją uogólnionej infekcji grzybiczej. Szybka identyfikacja patogenu i zastosowanie odpowiedniego leczenia ma istotne znaczenie dla życia chorych. AbStrActDue to the fact that the number of solid organ transplant recipients is increasing, the population of immunosuppressed individuals is growing. Immunosuppression predisposes organ transplant recipients to the development of fungal infections that cause not only graft failure but also mortality. Immunosuppression makes diagnosis difficult due to atypical signs and symptoms of mycoses. Treatment of infections may be complicated because of fungal resistance to commonly used drugs, drug interactions and the requirement to continue immunosuppression to avoid graft rejection. This article provides a review of superficial and invasive fungal infections within the skin, including diagnostic and therapeutic methods. Quick identification of the pathogen and appropriate treatment are essential to the life of patients.infekcje grzybicze skóry i tkanki podskórnej u chorych po transplantacji narządów Superficial and deep cutaneous fungal infections in solid organ transplant recipients

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Sporotrichosis: Recurrent Cutaneous, Articular, and Central Nervous System Infection in a Renal Transplant Recipient

Cited by 68 publications

References 30 publications

Sporothrix schenckii and Sporotrichosis

Sporothrix schenckii and Sporotrichosis

Infection by a Dimorphic Fungus Sporothrix schenckii in an Immunocompromised Patient

Superficial and deep cutaneous fungal infections in solid organ transplant recipients

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