SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

Mulyanti, Budi; Nugroho, Harbi Setyo; Wulandari, Chandra; Rahmawati, Yuni; Hasanah, Lilik; Hamidah, Ida; Pawinanto, Roer Eka; Majlis, Burhanuddin Yeop

doi:10.1155/2022/9135172

Cited by 7 publications

(4 citation statements)

References 100 publications

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“…In addition, the histological study showed no alteration of the liver structure. Renal dysfunction can be evaluated by simultaneous measurements of urea, creatinine and uric acid [18,26]. In this study, there were no changes in plasma levels of urea and creatinine of treated rats compared to controls rats.…”

Section: Discussionmentioning

confidence: 54%

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Minoue Kuum,

Tchadji,

Ndji Otto

et al. 2022

J. Pharm. Med. Res.

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This present work aimed to assess the subacute toxicity of the total aqueous extract of the dry bark of Albizia ferruginea in rats. Subacute toxicity was done in accordance with 2008 OECD Guideline 407, for oral toxicity at a daily dose for 28 days in rodents. The animals were divided into six groups of 10 rats each (5 males and 5 females). One control group received 10 mL/kg of distilled water, three groups received 200, 400 and 800 mg/kg of extract respectively, one satellite control group and one satellite treated group received 10 mL/kg of distilled water and 800 mg/kg extract respectively. After 28 days of treatment, the satellite groups were left under observation without treatment for an additional 14 days. Behavior, body weight and death rate were monitored during the experimental period. The relative weight of some organs, hematological and biochemical parameters and the histopathological study of the liver, kidneys and lungs were evaluated at the end of the experiment. There were no significant effects on body weight gain and the relative weight of organs investigated. At the 800 mg/kg dose, there was a significant increase in the level of monocytes by 26.53%; the mean corpuscular hemoglobin content (MCHT) of 18.18%; and in the corpuscular hemoglobin concentration (MCHC) of 20.70 %, only in male rats. ALT and ASAT activity were increased significantly in both male and female rats. These increases were not seen in satellite treated rats. The histology of the organs investigated showed no difference when comparing the treated rats to the control rats. The subacute toxicity study of total aqueous extract of the dry bark of Albizia ferruginea did not show any signs of significant toxicity for parameters studied in rats.

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Section: Discussionmentioning

confidence: 54%

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Minoue Kuum,

Tchadji,

Ndji Otto

et al. 2022

J. Pharm. Med. Res.

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“…The establishment of a bioimaging platform for detecting AKI and screening the therapeutic effects of drugs stands out as one of the most popular strategies for advancing clinical practice today. For such, a variety of bioimaging techniques including plasmonic and electrochemical detectors, the incorporation of nanoparticles, and a variety of biorecognition components (e.g., antibodies, , aptamers, molecular imprinting molecules are applied to improve the detector’s capacity for diagnosis …”

Section: Bioimaging Strategies For Akimentioning

confidence: 99%

Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury

Sitara,

Zhang,

Gao

et al. 2024

Chemical & Biomedical Imaging

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Acute kidney injury (AKI), a prevalent and complex clinical condition associated with elevated risks of morbidity and mortality, necessitates the meticulous detection and monitoring of kidney damage globally. Biomedicine has shown keen interest in molecular probes and detectors for AKI due to their sensitivity, rapidity, and cost-effectiveness. Bioimaging technologies play a significant role in identifying and quantifying AKI indicators, enhancing diagnostic approaches, and potentially refining clinical therapies for immediate injury control. Molecular probes serve as valuable tools for drug screening, uncovering renoprotective components, signaling pathways, and the nephrotoxic effects of drugs. This review comprehensively summarizes the latest advancements in molecular probes, emphasizing their exceptional efficacy in various characteristics, including renal cleanability, multichannel detection capability, near-infrared-II responsiveness, and reactivity toward reactive oxygen species. These probes offer enhanced benefits for assessing kidney damage and evaluating the therapeutic effects of medications while simultaneously reducing toxic effects. Additionally, the review delves into future potentials and challenges in this field, aiming to inspire the development and enhancement of molecular bioimaging for the early diagnosis and treatment of kidney diseases.

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“…These resonant plasma oscillations generate intense electromagnetic fields that extend outward from the nanoparticle surface into the surrounding medium, decaying evanescently away from the interface. Generally, the penetration depth of the evanescent field is on the order of tens to hundreds of nanometers, providing an intense localized electromagnetic field that can interact with and enhance the signature of target biomarker molecules within this distance [42].…”

Section: Definition and Explanation Of Lspr Phenomenon In Noble Metal...mentioning

confidence: 99%

Plasmonic Nanoparticle-Enhanced Optical Techniques for Cancer Biomarker Sensing

Fu,

Lin,

Karimi-Maleh

et al. 2023

Biosensors

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This review summarizes recent advances in leveraging localized surface plasmon resonance (LSPR) nanotechnology for sensitive cancer biomarker detection. LSPR arising from noble metal nanoparticles under light excitation enables the enhancement of various optical techniques, including surface-enhanced Raman spectroscopy (SERS), dark-field microscopy (DFM), photothermal imaging, and photoacoustic imaging. Nanoparticle engineering strategies are discussed to optimize LSPR for maximum signal amplification. SERS utilizes electromagnetic enhancement from plasmonic nanostructures to boost inherently weak Raman signals, enabling single-molecule sensitivity for detecting proteins, nucleic acids, and exosomes. DFM visualizes LSPR nanoparticles based on scattered light color, allowing for the ultrasensitive detection of cancer cells, microRNAs, and proteins. Photothermal imaging employs LSPR nanoparticles as contrast agents that convert light to heat, producing thermal images that highlight cancerous tissues. Photoacoustic imaging detects ultrasonic waves generated by LSPR nanoparticle photothermal expansion for deep-tissue imaging. The multiplexing capabilities of LSPR techniques and integration with microfluidics and point-of-care devices are reviewed. Remaining challenges, such as toxicity, standardization, and clinical sample analysis, are examined. Overall, LSPR nanotechnology shows tremendous potential for advancing cancer screening, diagnosis, and treatment monitoring through the integration of nanoparticle engineering, optical techniques, and microscale device platforms.

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SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

Cited by 7 publications

References 100 publications

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury

Plasmonic Nanoparticle-Enhanced Optical Techniques for Cancer Biomarker Sensing

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